N3-PEG3-tBu

ChemicalBook > CAS DataBase List > N3-PEG3-tBu

Product Name: N3-PEG3-tBu
CAS No.: 252881-73-5
Chemical Name: N3-PEG3-tBu
Synonyms: N3-PEG3-tBu;Azido-PEG3-COOtBu;N3-PEG3-CH2CH2-Boc;N?-PEG?-CH?CH?COOtBu;N3-PEG3-CH2CH2COOtBu;Azido-PEG3-tBu Ester;Azido-PEG3-CH2CH2COOtBu;N3-?PEG3-?t-?butyl ester;N3-PEG3-CH2CH2COOt<;N3-(CH2CH2O)3-CH2CH2COOt-Bu
CBNumber: CB12546985
Molecular Formula: C13H25N3O5
Formula Weight: 303.3547
MOL File: 252881-73-5.mol

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N3-PEG3-tBu Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A925065
Product name: Azido-PEG3-t-butylEster
Packaging: 1g
Price: $315
Updated: 2021/12/16

BroadPharm

Product number: BP-20637
Product name: Azido-PEG3-t-butylester
Purity: 98%
Packaging: 500mg
Price: $320
Updated: 2021/12/16

BroadPharm

Product number: BP-20637
Product name: Azido-PEG3-t-butylester
Purity: 98%
Packaging: 1g
Price: $440
Updated: 2021/12/16

ChemPep

Product number: 280701
Product name: N3-PEG3-tBu
Packaging: 1g
Price: $449
Updated: 2021/12/16

AK Scientific

Product number: AMTGC716
Product name: tert-butyl3-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}propanoate
Packaging: 5g
Price: $660
Updated: 2021/12/16

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N3-PEG3-tBu Chemical Properties,Usage,Production

Description

Azido-PEG3-t-butyl ester is a click chemistry reagent. The hydrophilic PEG spacer increases solubility in aqueous media. The azide (N3) group canis reactive with alkyne, such as BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Azido-PEG3-t-butyl Ester is used as a linker in the conjugation of peptides.

Biological Activity

N3-PEG3-tBu is a cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). It is also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used to synthesize PROTAC molecules.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

PEGs

Alkyl/ether

Cleavable

N3-PEG3-tBu Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N3-PEG3-tBu manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: azido-PEG3-t-Butyl ester 252881-73-5
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-23

252881-73-5, N3-PEG3-tBuRelated Search:

Azido-dPEG4-acid alpha-MaleiMidopropionyl-oMega-succiniMidyl-6(ethylene glycol) Amino-PEG4-acid O-(2-AMINOETHYL)-O-(2-AZIDOETHYL)HEPTAETHYLENE GLYCOL 2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL PEG-Azide, O-(2-Azidoethyl)-Oμ-methylpolyethylene glycol Z-9-aMino-4,7-dioxanonanoic acid 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-amine Amino-PEG6-alcohol O-(2-AMINOETHYL)-O'-(2-(BOC-AMINO)ETHYL) Azido-PEG12-azide N3-PEG4-tBu H2N-PEG8-tBu 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-AZIDE Amino-PEG8-azide AMINO-PEG12-T-BUTYL ESTER H2N-PEG6-tBu 17-Azido-3,6,9,12,15-pentaoxaheptadecan-1-amine

N3-PEG3-CH2CH2COOtBu

N3-PEG3-tBu

N3-PEG3-CH2CH2COOtBu

3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanoic acid 1,1-dimethylethyl ester

tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate

Azido-PEG3-COOtBu

tert-Butyl 3-(2-(2-(2-azidoethoxyl)ethoxy)ethoxy)propanoate

N3-?PEG3-?t-?butyl ester

N3-PEG3-CH2CH2-Boc

N?-PEG?-CH?CH?COOtBu

N3-(CH2CH2O)3-CH2CH2COOt-Bu

Azido-PEG3-tBu Ester

N3-PEG3-CH2CH2COOtBu/Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester

Azido-PEG3-CH2CH2COOtBu

N3-PEG3-CH2CH2COOt<

252881-73-5

SiChem

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