Azido-dPEG4-acid
- Product Name
- Azido-dPEG4-acid
- CAS No.
- 1056024-94-2
- Chemical Name
- Azido-dPEG4-acid
- Synonyms
- 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoic acid;N3-PEG3-COOH;Azido-dPEG4-acid;N3-PEG3-CH2CH2COOH;Azido-PEG3-CH2CH2COOH;N3-PEG3-COOH,Azido-PEG3-acid;N3-(CH2)2-O-(CH2-CH2-O)2-(CH2)2-COOH;3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoicacid/N3-PEG3-CH2CH2COOH;N3-PEG3-CH2CH2COOH/Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-
- CBNumber
- CB13146560
- Molecular Formula
- C9H17N3O5
- Formula Weight
- 247.25
- MOL File
- 1056024-94-2.mol
Azido-dPEG4-acid Property
- solubility
- DMSO : 100 mg/mL (404.45 mM; Need ultrasonic)
- form
- Liquid
- color
- Colorless to light yellow
Safety
- HS Code
- 2918999090
N-Bromosuccinimide Price
- Product number
- A965575
- Product name
- Azido-peg3Acid
- Packaging
- 50mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- A965575
- Product name
- Azido-peg3Acid
- Packaging
- 100mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- BIPG1105
- Product name
- Azido-PEG3-acid
- Packaging
- 500mg
- Price
- $378
- Updated
- 2021/12/16
- Product number
- BP-21583
- Product name
- Azido-PEG3-acid
- Purity
- 98%
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- AMTGC715
- Product name
- 3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanoicacid
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
Azido-dPEG4-acid Chemical Properties,Usage,Production
Description
Azido-PEG3-acid is a crosslinker containing an azide(N3) group with a carboxylic acid (CO2H). The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.
Definition
ChEBI: 3-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}propanoic acid is an organonitrogen compound.
Biological Activity
Azido-dPEG4-acid is a PEG-based PROTAC linker for the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. It is also a non-cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| PEGs
| Non-cleavable
|
Azido-dPEG4-acid Preparation Products And Raw materials
Raw materials
Preparation Products
Azido-dPEG4-acid Suppliers
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- 029-86217788 13892832556
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- China
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View Lastest Price from Azido-dPEG4-acid manufacturers
- Product
- azido-PEG3-Acid 1056024-94-2
- Price
- US $0.00/g
- Min. Order
- 10g
- Purity
- >98.00%
- Supply Ability
- 10g
- Release date
- 2024-03-23