Azido-PEG3-Sulfone-PEG4-t-butyl ester
- Product Name
- Azido-PEG3-Sulfone-PEG4-t-butyl ester
- CAS No.
- 2055023-76-0
- Chemical Name
- Azido-PEG3-Sulfone-PEG4-t-butyl ester
- Synonyms
- Azido-PEG3-Sulfone-PEG4-Boc;Azido-PEG3-Sulfone-PEG4-t-butyl ester;tert-butyl 3-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylsulfonyl]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
- CBNumber
- CB23162873
- Molecular Formula
- C23H45N3O11S
- Formula Weight
- 571.6819
- MOL File
- 2055023-76-0.mol
N-Bromosuccinimide Price
- Product number
- BP-23242
- Product name
- Azido-PEG3-Sulfone-PEG4-t-butylester
- Purity
- 97%
- Packaging
- 100mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- BP-23242
- Product name
- Azido-PEG3-Sulfone-PEG4-t-butylester
- Purity
- 97%
- Packaging
- 250mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- BP-23242
- Product name
- Azido-PEG3-Sulfone-PEG4-t-butylester
- Purity
- 97%
- Packaging
- 500mg
- Price
- $680
- Updated
- 2021/12/16
- Product number
- BP-23242
- Product name
- Azido-PEG3-Sulfone-PEG4-t-butylester
- Purity
- 97%
- Packaging
- 1g
- Price
- $1300
- Updated
- 2021/12/16
Azido-PEG3-Sulfone-PEG4-t-butyl ester Chemical Properties,Usage,Production
Description
Azido-PEG3-Sulfone-PEG4-t-butyl ester is a PEG linker containing one azide group and one t-butyl protected carboxyl group. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group (COOH) prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions.
Uses
Azido-PEG3-Sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-Sulfone-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG3-Sulfone-PEG4-t-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Azido-PEG3-Sulfone-PEG4-t-butyl ester manufacturers
- Product
- Azido-PEG3-Sulfone-PEG4-t-butyl ester 2055023-76-0
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >95.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-28