2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-
- Product Name
- 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-
- CAS No.
- 452339-73-0
- Chemical Name
- 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-
- Synonyms
- (5R)-5-(2,2-DiMethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one;(R)-5-(2,2-DIMETHYL-4H-BENZO[D][1,3]DIOXIN-6-YL)OXAZOLIDIN-2-ONE;BNKY020-VT04;Vilanterol internate 1;Vilanterol Impurity 29;Vilanterol Impurity 74;(5R)-2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl);(5R)-2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-y...;(R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxazolidinone;(R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one
- CBNumber
- CB12563399
- Molecular Formula
- C13H15NO4
- Formula Weight
- 249.26
- MOL File
- 452339-73-0.mol
2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Property
- Melting point:
- 160 - 163°C
- Boiling point:
- 489.6±45.0 °C(Predicted)
- Density
- 1.223±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- pka
- 12.29±0.40(Predicted)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D456836
- Product name
- (R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one
- Packaging
- 100mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 1968CS
- Product name
- (5R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one
- Packaging
- 100mg
- Price
- $101
- Updated
- 2021/12/16
- Product number
- 1968CS
- Product name
- (5R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one
- Packaging
- 250mg
- Price
- $127
- Updated
- 2021/12/16
- Product number
- AA00DAZ6
- Product name
- (5R)-5-(2,2-Dimethyl-4h-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $176
- Updated
- 2021/12/16
- Product number
- CD11121927
- Product name
- (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one
- Purity
- 97%
- Packaging
- 250mg
- Price
- $218
- Updated
- 2021/12/16
2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Chemical Properties,Usage,Production
Uses
(5R)-5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-2-Oxazolidinone (2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-) is a reagent applied in the preparation of alkyl-linked di-phenyl aminoalcohols as long-acting β2 adrenergic receptor agonist. It is used as an antedrug.
Synthesis
(R)-2-amino-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethan-1-ol (29.8g, 134.0mmol, 1.0eq.) and tetrahydrofuran (300mL) were added to the reaction flask under nitrogen protection, the reaction solution was heated to 40-60°C, and N, N'- Carbonyldiimidazole (22.7 g, 140.0 mmol, 1.05 eq.).After the addition, the reaction solution was kept at a temperature of 40-60° C. and stirred until the raw material reaction was completed. After the reaction, the solution was cooled to 15-30° C., and water (400 mL) was added. Then, the mixture was continuously cooled to 0-10°C and kept stirring. The precipitated solid was filtered, and the filter cake was washed with water. The filter cake was collected and dried under reduced pressure to obtain 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- (30 g, 120.4 mmol, 89.9% yield).
2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Preparation Products And Raw materials
Raw materials
Preparation Products
2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Suppliers
View Lastest Price from 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- manufacturers
- Product
- 2-Oxazolidinone, 5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-,5R- 452339-73-0
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- ≥99%
- Supply Ability
- Inquiry
- Release date
- 2022-10-28
- Product
- 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- 452339-73-0
- Price
- US $66.00/KG
- Min. Order
- 1250KG
- Purity
- 99.8%
- Supply Ability
- 2T
- Release date
- 2023-07-21
- Product
- (5R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-on e 452339-73-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100tons
- Release date
- 2023-09-12