ChemicalBook > CAS DataBase List > (2-Aminophenyl)dimethylphosphine Oxide

(2-Aminophenyl)dimethylphosphine Oxide

Product Name
(2-Aminophenyl)dimethylphosphine Oxide
CAS No.
1197953-47-1
Chemical Name
(2-Aminophenyl)dimethylphosphine Oxide
Synonyms
Buglitinibintermediate;2-(Dimethyloxonyl)aniline;Brigatinib intermediates;2-(Dimethylphosphinyl)aniline;2-(diMethylphosphoryl)aniline;2- (dimethylphosphino) aniline;2-(diMethylphosphoryl)aniline HCl;2-(diMethylphosphoryl)benzenaMine;2-(Dimethylphosphinyl)benzenamine;3-(Dimethylphosphinyl)benzenamine
CBNumber
CB12595392
Molecular Formula
C8H12NOP
Formula Weight
169.16
MOL File
1197953-47-1.mol
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(2-Aminophenyl)dimethylphosphine Oxide Property

Boiling point:
367.5±34.0 °C(Predicted)
Density 
1.11±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
1.10±0.10(Predicted)
InChI
InChI=1S/C8H12NOP/c1-11(2,10)8-6-4-3-5-7(8)9/h3-6H,9H2,1-2H3
InChIKey
DHHGHQKIKXKQGJ-UHFFFAOYSA-N
SMILES
C1(N)=CC=CC=C1P(C)(C)=O
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Safety

RIDADR 
UN2811
HS Code 
2923900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A638018
Product name
(2-Aminophenyl)dimethylphosphineOxide
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
A638018
Product name
(2-Aminophenyl)dimethylphosphineOxide
Packaging
500mg
Price
$110
Updated
2021/12/16
AK Scientific
Product number
Z3963
Product name
(2-Aminophenyl)dimethylphosphineoxide
Packaging
1g
Price
$134
Updated
2021/12/16
Apolloscientific
Product number
OR49045
Product name
2-Dimethylphosphorylaniline
Packaging
1g
Price
$169
Updated
2021/12/16
AK Scientific
Product number
Z3963
Product name
(2-Aminophenyl)dimethylphosphineoxide
Packaging
10g
Price
$458
Updated
2021/12/16
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(2-Aminophenyl)dimethylphosphine Oxide Chemical Properties,Usage,Production

Uses

(2-Aminophenyl)dimethylphosphine Oxide is mainly used as a raw material or reagent for organic synthesis and can be used to prepare other compounds such as phosphine oxide derivatives and pyrimidine derivatives.

Synthesis

(2-Aminophenyl)dimethylphosphine Oxide is prepared by the reaction of 2-Iodoaniline and Dimethylphosphine oxide. The specific synthesis steps are as follows:
To a solution of 2-iodoaniline ( 1.0 eq) and dimethylphosphine oxide (1.1 eq) in DMF were added potassium phosphate ( 1.1 eq) and palladium acetate/Xantphos (catalytic). The reaction was stirred at 150 °C for 3 hours and cooled to room temperature. The solvent was evaporated and the residue was worked up with DCM/water. The crude product was purified with a column(EtOAc/MeOH 10: 1 ) to give 1 as a brown solid (80percent yield).

(2-Aminophenyl)dimethylphosphine Oxide Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-Aminophenyl)dimethylphosphine Oxide Suppliers

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View Lastest Price from (2-Aminophenyl)dimethylphosphine Oxide manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-(diMethylphosphoryl)aniline 1197953-47-1
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09
Henan Aochuang Chemical Co.,Ltd.
Product
2-(diMethylphosphoryl)aniline 1197953-47-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-(diMethylphosphoryl)aniline 1197953-47-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

1197953-47-1, (2-Aminophenyl)dimethylphosphine OxideRelated Search:

Dichloroethane (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide 2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline Brigatinib AP26113

  • 2-(diMethylphosphoryl)aniline
  • 2-(diMethylphosphoryl)benzenaMine
  • (2-AMinophenyl)diMethylphosphine oxide
  • Benzenamine, 2-(dimethylphosphinyl)-
  • 2-(Dimethylphosphinyl)benzenamine
  • 2-(Dimethylphosphinyl)benzeneamine
  • 2-(Dimethylphosphinyl)aniline
  • 2-(diMethylphosphoryl)aniline HCl
  • Brigatinib intermediates
  • 2-(Dimethyloxonyl)aniline
  • Buglitinibintermediate
  • 2- (dimethylphosphino) aniline
  • 3-(Dimethylphosphinyl)benzenamine
  • 1197953-47-1
  • C8H12NOP