(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

Product Name: (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
CAS No.: 1197953-49-3
Chemical Name: (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
Synonyms: (2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide;AP26113 intermediates 1;4-(orthodimethylphosphinylanilino)-5-chloro-2-chloropyrimidine;2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine;2,5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine;2,5-dichloro-N-(2-(dimethylphosphoryl)phenyl)pyrimidin-4-ami...;4-Pyrimidinamine, 2,5-dichloro-N-[2-(dimethylphosphinyl)phenyl]-;2-[(2,5-Dichloro-4-pyrimidinyl)amino]phenyl]dimethylphosphine Oxide;2,5- Dichloro -N-[2- (dimethylphosphino) phenyl ]-4- pyrimidinamine *
CBNumber: CB32677388
Molecular Formula: C12H12Cl2N3OP
Formula Weight: 316.12
MOL File: 1197953-49-3.mol

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(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Property

Boiling point:: 527.5±50.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.30±0.10(Predicted)
InChI: InChI=1S/C12H12Cl2N3OP/c1-19(2,18)10-6-4-3-5-9(10)16-11-8(13)7-15-12(14)17-11/h3-7H,1-2H3,(H,15,16,17)
InChIKey: XIKUAKVCJMVXCI-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 0956EB
Product name: (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
Packaging: 250mg
Price: $120
Updated: 2021/12/16

Chemenu

Product number: CM166384
Product name: (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
Purity: 95%
Packaging: 1g
Price: $153
Updated: 2021/12/16

Ambeed

Product number: A117681
Product name: (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
Purity: 96%
Packaging: 5g
Price: $335
Updated: 2021/12/16

Chemenu

Product number: CM166384
Product name: (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
Purity: 95%
Packaging: 5g
Price: $421
Updated: 2021/12/16

Crysdot

Product number: CD11333969
Product name: (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
Purity: 95+%
Packaging: 5g
Price: $446
Updated: 2021/12/16

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(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Chemical Properties,Usage,Production

Uses

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide is an intermediate of AP26113 which is a kind of effective ALK inhibitor.

Synthesis

25 mL of a one-necked flask was added DMF (3 mL), 2,5,6-trichloro pyrimidine (0.72 g, 3.9 mmol) was added successively with stirring,2- (dimethylphosphonino) aniline (0.5 g, 3 mmol)Anhydrous potassium carbonate (0.62 g, 4.5 mmol), heated to 60 ° C and stirred for 4 h.(30 mL x 2), the organic phase was combined, washed with water (60 mL x 2), and the organic layer was dried over anhydrous sodium sulfate, and the organic layer was washed with ethyl acetate (30 mL) and water (30 mL) Filtered and concentrated, and the residue was passed through a silica gel column to give 0.8 g of a pale yellow solid (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide.

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Suppliers

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View Lastest Price from (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide manufacturers

Enki Biopharmaceuticals (Shanghai) Limited

Product: 2，5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine 1197953-49-3
Price: US $0.00/kg
Min. Order: 10kg
Purity: 99.0%
Supply Ability: 1000
Release date: 2023-11-25

Henan Fengda Chemical Co., Ltd

Product: (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide 1197953-49-3
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

Suzhou Ryan Pharmachem Technology Co.,Ltd.

Product: 2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine 1197953-49-3
Price: US $0.00-0.00/KG
Min. Order: 100g
Purity: 98%
Supply Ability: KG
Release date: 2021-09-16

1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxideRelated Search:

1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro- 4-fluoro-2-Methoxy-5-nitroaniline 1-(1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl)-4-Methylpiperazine 2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline 2-(diMethylphosphoryl)aniline

2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine

(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

4-(orthodimethylphosphinylanilino)-5-chloro-2-chloropyrimidine

2-[(2,5-Dichloro-4-pyrimidinyl)amino]phenyl]dimethylphosphine Oxide

2,5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine

4-Pyrimidinamine, 2,5-dichloro-N-[2-(dimethylphosphinyl)phenyl]-

2,5-dichloro-N-(2-(dimethylphosphoryl)phenyl)pyrimidin-4-ami...

2,5- Dichloro -N-[2- (dimethylphosphino) phenyl ]-4- pyrimidinamine *

AP26113 intermediates 1

1197953-49-3

197953-49-3

761140-75-9

C12H12Cl2N3OP

1197953-49-3