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(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

Product Name
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
CAS No.
1197953-49-3
Chemical Name
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
Synonyms
(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide;AP26113 intermediates 1;4-(orthodimethylphosphinylanilino)-5-chloro-2-chloropyrimidine;2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine;2,5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine;2,5-dichloro-N-(2-(dimethylphosphoryl)phenyl)pyrimidin-4-ami...;4-Pyrimidinamine, 2,5-dichloro-N-[2-(dimethylphosphinyl)phenyl]-;2-[(2,5-Dichloro-4-pyrimidinyl)amino]phenyl]dimethylphosphine Oxide;2,5- Dichloro -N-[2- (dimethylphosphino) phenyl ]-4- pyrimidinamine *
CBNumber
CB32677388
Molecular Formula
C12H12Cl2N3OP
Formula Weight
316.12
MOL File
1197953-49-3.mol
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(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Property

Boiling point:
527.5±50.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
0.30±0.10(Predicted)
InChI
InChI=1S/C12H12Cl2N3OP/c1-19(2,18)10-6-4-3-5-9(10)16-11-8(13)7-15-12(14)17-11/h3-7H,1-2H3,(H,15,16,17)
InChIKey
XIKUAKVCJMVXCI-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
0956EB
Product name
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
Packaging
250mg
Price
$120
Updated
2021/12/16
Chemenu
Product number
CM166384
Product name
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
Purity
95%
Packaging
1g
Price
$153
Updated
2021/12/16
Ambeed
Product number
A117681
Product name
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
Purity
96%
Packaging
5g
Price
$335
Updated
2021/12/16
Chemenu
Product number
CM166384
Product name
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
Purity
95%
Packaging
5g
Price
$421
Updated
2021/12/16
Crysdot
Product number
CD11333969
Product name
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
Purity
95+%
Packaging
5g
Price
$446
Updated
2021/12/16
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(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Chemical Properties,Usage,Production

Description

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide is a pharmaceutical intermediate compound used in the synthesis of the antitumour agent Brigatinib. Brigatinib is an orally administered, potent, selective anaplastic lymphoma kinase ( Brigatinib is an oral, potent, selective anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) tyrosine kinase inhibitor approved for the treatment of adult patients with advanced ALK-positive non-small cell lung cancer (NSCLC) who have not received prior ALK inhibitor therapy.

Uses

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide is an intermediate of AP26113 which is a kind of effective ALK inhibitor.

Synthesis

25 mL of a one-necked flask was added DMF (3 mL), 2,5,6-trichloro pyrimidine (0.72 g, 3.9 mmol) was added successively with stirring,2- (dimethylphosphonino) aniline (0.5 g, 3 mmol)Anhydrous potassium carbonate (0.62 g, 4.5 mmol), heated to 60 ° C and stirred for 4 h.(30 mL x 2), the organic phase was combined, washed with water (60 mL x 2), and the organic layer was dried over anhydrous sodium sulfate, and the organic layer was washed with ethyl acetate (30 mL) and water (30 mL) Filtered and concentrated, and the residue was passed through a silica gel column to give 0.8 g of a pale yellow solid (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide.

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Suppliers

China 163 India 2 United States 4 Global 169
Shanghai Hope Chem Co., Ltd.，
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+21-18501659228 18501659228
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sales@hope-chem.com
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info@hope-chem.com
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China
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Hangzhou Chemtrue Bio-Tech Co.,Ltd.
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0571-86828652 18857119830
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0571-83522824
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sales@chemtrue-bio.com
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Liuyang huarui material technology co., ltd.
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13467605171
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Enki Biopharmaceuticals(Shanghai) Limited
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021-57680965 13916707528
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(21) 5768 0922
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18721429218
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Ruichen Kangda Biomedical (Wuhan) Co., Ltd.
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ChemFuture PharmaTech (Jiangsu) Ltd
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
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Accela ChemBio Co.,Ltd.
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021-50795510 4000665055
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021-50795055
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Jinan Trio PharmaTech Co., Ltd.
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+86 (531) 88811783
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View Lastest Price from (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide manufacturers

Enki Biopharmaceuticals (Shanghai) Limited
Product
2，5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine 1197953-49-3
Price
US $0.00/kg
Min. Order
10kg
Purity
99.0%
Supply Ability
1000
Release date
2023-11-25
Henan Fengda Chemical Co., Ltd
Product
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide 1197953-49-3
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09
Suzhou Ryan Pharmachem Technology Co.,Ltd.
Product
2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine 1197953-49-3
Price
US $0.00-0.00/KG
Min. Order
100g
Purity
98%
Supply Ability
KG
Release date
2021-09-16

1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxideRelated Search:

1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro- 4-fluoro-2-Methoxy-5-nitroaniline 1-(1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl)-4-Methylpiperazine 2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline 2-(diMethylphosphoryl)aniline

  • 2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine
  • (2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
  • 4-(orthodimethylphosphinylanilino)-5-chloro-2-chloropyrimidine
  • 2-[(2,5-Dichloro-4-pyrimidinyl)amino]phenyl]dimethylphosphine Oxide
  • 2,5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine
  • 4-Pyrimidinamine, 2,5-dichloro-N-[2-(dimethylphosphinyl)phenyl]-
  • 2,5-dichloro-N-(2-(dimethylphosphoryl)phenyl)pyrimidin-4-ami...
  • 2,5- Dichloro -N-[2- (dimethylphosphino) phenyl ]-4- pyrimidinamine *
  • AP26113 intermediates 1
  • 1197953-49-3
  • 197953-49-3
  • 761140-75-9
  • C12H12Cl2N3OP
  • 1197953-49-3