ChemicalBook > CAS DataBase List > (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
- Product Name
- (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
- CAS No.
- 1197953-49-3
- Chemical Name
- (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
- Synonyms
- (2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide;AP26113 intermediates 1;4-(orthodimethylphosphinylanilino)-5-chloro-2-chloropyrimidine;2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine;2,5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine;2,5-dichloro-N-(2-(dimethylphosphoryl)phenyl)pyrimidin-4-ami...;4-Pyrimidinamine, 2,5-dichloro-N-[2-(dimethylphosphinyl)phenyl]-;2-[(2,5-Dichloro-4-pyrimidinyl)amino]phenyl]dimethylphosphine Oxide;2,5- Dichloro -N-[2- (dimethylphosphino) phenyl ]-4- pyrimidinamine *
- CBNumber
- CB32677388
- Molecular Formula
- C12H12Cl2N3OP
- Formula Weight
- 316.12
- MOL File
- 1197953-49-3.mol
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(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Property
- Boiling point:
- 527.5±50.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.30±0.10(Predicted)
- InChI
- InChI=1S/C12H12Cl2N3OP/c1-19(2,18)10-6-4-3-5-9(10)16-11-8(13)7-15-12(14)17-11/h3-7H,1-2H3,(H,15,16,17)
- InChIKey
- XIKUAKVCJMVXCI-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
AK Scientific
- Product number
- 0956EB
- Product name
- (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
Chemenu
- Product number
- CM166384
- Product name
- (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
- Purity
- 95%
- Packaging
- 1g
- Price
- $153
- Updated
- 2021/12/16
Ambeed
- Product number
- A117681
- Product name
- (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
- Purity
- 96%
- Packaging
- 5g
- Price
- $335
- Updated
- 2021/12/16
Chemenu
- Product number
- CM166384
- Product name
- (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
- Purity
- 95%
- Packaging
- 5g
- Price
- $421
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11333969
- Product name
- (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide
- Purity
- 95+%
- Packaging
- 5g
- Price
- $446
- Updated
- 2021/12/16
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(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Chemical Properties,Usage,Production
Uses
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide is an intermediate of AP26113 which is a kind of effective ALK inhibitor.
Synthesis
25 mL of a one-necked flask was added DMF (3 mL), 2,5,6-trichloro pyrimidine (0.72 g, 3.9 mmol) was added successively with stirring,2- (dimethylphosphonino) aniline (0.5 g, 3 mmol)Anhydrous potassium carbonate (0.62 g, 4.5 mmol), heated to 60 ° C and stirred for 4 h.(30 mL x 2), the organic phase was combined, washed with water (60 mL x 2), and the organic layer was dried over anhydrous sodium sulfate, and the organic layer was washed with ethyl acetate (30 mL) and water (30 mL) Filtered and concentrated, and the residue was passed through a silica gel column to give 0.8 g of a pale yellow solid (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide.
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide manufacturers
Enki Biopharmaceuticals (Shanghai) Limited
- Product
- 2，5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine 1197953-49-3
- Price
- US $0.00/kg
- Min. Order
- 10kg
- Purity
- 99.0%
- Supply Ability
- 1000
- Release date
- 2023-11-25
Henan Fengda Chemical Co., Ltd
- Product
- (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide 1197953-49-3
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
Suzhou Ryan Pharmachem Technology Co.,Ltd.
- Product
- 2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine 1197953-49-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 100g
- Purity
- 98%
- Supply Ability
- KG
- Release date
- 2021-09-16
1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxideRelated Search:
1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro-
4-fluoro-2-Methoxy-5-nitroaniline
1-(1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl)-4-Methylpiperazine
2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline
2-(diMethylphosphoryl)aniline