ChemicalBook > CAS DataBase List > Fatostatin A
Fatostatin A
- Product Name
- Fatostatin A
- CAS No.
- 298197-04-3
- Chemical Name
- Fatostatin A
- Synonyms
- CS-2596;Fatostatin;Fatostatin A;Fatostatin HBr;Fatostatin A HBr;25B11 hydrobromide;Fatostatin HBr，125B-11;Fatostatin hydrobromide;Fatostatin A HydrobroMide;Fatostatin - CAS 298197-04-3 - Calbiochem
- CBNumber
- CB12602999
- Molecular Formula
- C18H19BrN2S
- Formula Weight
- 375.33
- MOL File
- 298197-04-3.mol
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Fatostatin A Property
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥10mg/mL
- form
- powder
- color
- light yellow to yellow
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- F8932
- Product name
- Fatostatin hydrobromide
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $60
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 341329
- Product name
- Fatostatin
- Packaging
- 25mg
- Price
- $201
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13562
- Product name
- Fatostatin (hydrobromide)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $68
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13562
- Product name
- Fatostatin (hydrobromide)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $95
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- F8932
- Product name
- Fatostatin hydrobromide
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $550
- Updated
- 2024/03/01
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Fatostatin A Chemical Properties,Usage,Production
Uses
Fatostatin hydrobromide has been used:
- to study its anti-cancer activity and effects on mitotic microtubule spindle
- to study its effects on stomatal development
- to prevent SREBP cleavage-activating protein (SCAP)-mediated escort of sterol regulatory element-binding proteins (SREBPs)
Uses
Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP). Fatostatin A reverses hyperglycemia in diabetic mice. Cell permeable. Fatostatin A is used for the treatment and/or prevention of one or more metabolic disorders.
General Description
Fatostatin is a non-sterol diarylthiazole derivative. It prevents insulin-induced adipogenesis and lowers the amounts of fatty acid, triglyceride and low-density lipoprotein. Fatostatin has anti tumor and antimitotic properties.
Biological Activity
fatostatin a is an inhibitor of sterol regulatory element binding protein (srebp), which can inhibit the activation of srebp-1 and srebp-2[1].fatostatin a (0.1-1 μm; 3 days) inhibits the androgen-independent proliferation of prostate cancer cell in a manner independent of the known igf1 signaling pathway. fatostatin a inhibits insulin-induced fat formation in 3t3-l1 cells[2].fatostatin a (30 mg/kg; 150 ml; i.p.; daily for 28 days) prevents obese ob/ob mice from increasing their weight, blood sugar, and liver fat accumulation, even if they do not control the food intake of mice[1].[1]. kamisuki s, et al. a small molecule that blocks fat synthesis by inhibiting the activation of srebp. chem biol. 2009, 16(8): 882-92.[2]. choi y, et al. identification of bioactive molecules by adipogenesis profiling of organic compounds. j biol chem. 2003, 278(9): 7320-4.
Biochem/physiol Actions
Fatostatin hydrobromide is an SREBP inhibitor. Fatostatin hydrobromide inhibits fat production and lowers glucose levels in mice by inhibiting SREBP (Sterol Regulatory Element Binding Proteins).
storage
Store at +4°C
Fatostatin A Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Fatostatin A manufacturers
Shaanxi Haibo Biotechnology Co., Ltd
- Product
- Fatostatin A 298197-04-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-29
298197-04-3, Fatostatin ARelated Search:
Fatostatin A
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N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
BMS 777607
TMC-207