ChemicalBook > CAS DataBase List > α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine

α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine

Product Name
α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine
CAS No.
305372-78-5
Chemical Name
α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine
Synonyms
CCT036477;Wnt Pathway Inhibitor XI, CCT036477;N-((4-chlorophenyl)(2-methyl-1H-indol-3-yl)methyl)pyridin-2-amine;α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine;Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem;1H-Indole-3-methanamine, α-(4-chlorophenyl)-2-methyl-N-2-pyridinyl-
CBNumber
CB12621741
Molecular Formula
C21H18ClN3
Formula Weight
347.84
MOL File
305372-78-5.mol
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α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine Property

Melting point:
>167°C (dec.)
Boiling point:
546.0±45.0 °C(Predicted)
Density 
1.301±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: ≥20mg/mL (warm to 60°C)
pka
17.33±0.30(Predicted)
form 
powder
color 
white to tan
Stability:
Light Sensitive
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0151
Product name
CCT036477
Purity
≥98% (HPLC)
Packaging
5mg
Price
$121
Updated
2025/07/31
Sigma-Aldrich
Product number
681674
Product name
Wnt Pathway Inhibitor XI, CCT036477
Packaging
5mg
Price
$150
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0151
Product name
CCT036477
Purity
≥98% (HPLC)
Packaging
25mg
Price
$318
Updated
2025/07/31
Usbiological
Product number
005838
Product name
CCT036477
Packaging
25mg
Price
$446
Updated
2021/12/16
TRC
Product number
C227900
Product name
CCT036477
Packaging
25mg
Price
$135
Updated
2021/12/16
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α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine Chemical Properties,Usage,Production

Uses

CCT036477 is an inhibitor of Wnt signaling. Studies show that CCT036477 does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.

Definition

ChEBI: N-[(4-chlorophenyl)-(2-methyl-1H-indol-3-yl)methyl]-2-pyridinamine is a member of indoles.

Biological Activity

CCT036477 is an inhibitor of Wnt signaling. It does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.

α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine Preparation Products And Raw materials

Raw materials

Preparation Products

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α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine Suppliers

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305372-78-5, α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMineRelated Search:

2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-diMethyl-1(2H)- isoquinolinylidene)acetaMide BML-286

  • CCT036477
  • α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine
  • Wnt Pathway Inhibitor XI, CCT036477
  • N-((4-chlorophenyl)(2-methyl-1H-indol-3-yl)methyl)pyridin-2-amine
  • Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem
  • 1H-Indole-3-methanamine, α-(4-chlorophenyl)-2-methyl-N-2-pyridinyl-
  • 305372-78-5
  • Aromatics, Heterocycles, Indole Deribatives, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals