ChemicalBook > CAS DataBase List > AgoMelatine-D6

AgoMelatine-D6

Product Name: AgoMelatine-D6
CAS No.: 1079389-42-6
Chemical Name: AgoMelatine-D6
Synonyms: S-20098 D6;D6-Agomelatine;AgoMelatine-D6;[2H6]-Agomelatine;Beflubutamid Impurity 4 (Bromobutide);N-{2-[7-(2H?)methoxynaphthalen-1-yl]ethyl}(2H?)acetamide;Acetamide-2,2,2-d3, N-[2-[7-(methoxy-d3)-1-naphthalenyl]ethyl]-;Agomelatine D6Q: What is Agomelatine D6 Q: What is the CAS Number of Agomelatine D6 Q: What is the storage condition of Agomelatine D6 Q: What are the applications of Agomelatine D6
CBNumber: CB12646212
Molecular Formula: C15H11D6NO2
Formula Weight: 249.34
MOL File: 1079389-42-6.mol

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AgoMelatine-D6 Property

storage temp.: Store at -20°C
solubility: Methanol: soluble
form: A solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26447
Product name: Agomelatine-d6
Packaging: 1mg
Price: $359
Updated: 2024/03/01

TRC

Product number: A430003
Product name: Agomelatine-d6
Packaging: 10mg
Price: $1320
Updated: 2021/12/16

ChemScene

Product number: CS-0019795
Product name: AgomelatineD6
Packaging: 1mg
Price: $280
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: D32833
Product name: Agomelatine-d6
Packaging: 1mg
Price: $490
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0014212
Product name: AGOMELATINE-D6
Purity: 95.00%
Packaging: 5MG
Price: $497.17
Updated: 2021/12/16

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AgoMelatine-D6 Chemical Properties,Usage,Production

Uses

Agomelatine-d6 is labelled Agomelatine (A430000) which is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively.

Biological Activity

Agomelatine-d6 is intended for use as an internal standard for the quantification of agomelatine by GC- or LC-MS. Agomelatine is an agonist of melatonin (MT) receptors and a derivative of melatonin .1 It binds to MT1 and MT2 receptors (Kis = 0.14 and 0.41 nM, respectively) and has an EC50 value of 0.1 nM in a [35S]GTPγS binding assay using CHO cells expressing MT2 receptors. Agomelatine is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B and 5-HT2C (Kis = 0.26 and 0.71 nM, respectively, for the human receptors).2 Agomelatine (40 mg/kg) inhibits the penile erection response induced by the 5-HT2 agonist Ro 60-0175 in rats. It also increases extracellular levels of noradrenaline and dopamine in the frontal cortex of freely moving rats when administered at doses ranging from 20 to 80 mg/kg. Agomelatine (10 mg/kg) reduces immobility time in the forced swim test and increases the amount of time spent in the open arms of the elevated plus maze, indicating antidepressant-like and anxiolytic-like activity, in a transgenic neuroendocrine model of depression.3 It also increases the rate of readjustment to circadian activity cycles following an induced phase shift.

IC 50

MT2; MT1

References

1.Poissonnier-Durieux, S., Ettaoussi, M., Pérès, B., et al.Synthesis of 3-phenylnaphthalenic derivatives as new selective MT2 melatoninergic ligandsBioorg. Med. Chem.16(18)8339-8348(2008) 2.Millan, M.J., Gobert, A., Lejeune, F., et al.The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathwaysJ. Pharmacol. Exp. Ther.306(3)954-964(2003) 3.Barden, N., Shink, E., Labbé, M., et al.Antidepressant action of agomelatine (S 20098) in a transgenic mouse modelProg. Neuropsychopharmacol. Biol. Psychiatry29(6)908-916(2005)

AgoMelatine-D6 Preparation Products And Raw materials

Raw materials

Preparation Products

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1079389-42-6, AgoMelatine-D6Related Search:

2-(7-methoxy-3,4-dihydronaphthalen-1-yl)ethan-1-amine (E)-2-(7-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)ethan-1-amine 2-(7-Methoxynaphthalen-1-yl)acetamide 7-DesMethylagoMelatine 2-(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)ethan-1-amine 2-(7-Hydroxy-1-naphthyl)ethylaMine 1-NaphthaleneacetaMide, 1,2,3,4-tetrahydro-7-Methoxy- AGOMELATINE 3-Hydroxy Agomelatine AcetaMide, N,N-bis[2-(7-Methoxy-1-naphthalenyl)ethyl]- 3,4-Dihydro Agomelatine N-acetyl-N-(2-(7-Methoxynaphthalen-1-yl)ethyl)acetaMide Desacetyl-7-desMethyl AgoMelatine HydrobroMide 2-(7-Methoxy-1-naphthyl)ethylamine hydrochloride (E)-N-(2-(7-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)ethyl)acetamide 7-DesMethyl-3-hydroxyagoMelatine

AgoMelatine-D6

[2H6]-Agomelatine

S-20098 D6

Agomelatine D6Q: What is Agomelatine D6 Q: What is the CAS Number of Agomelatine D6 Q: What is the storage condition of Agomelatine D6 Q: What are the applications of Agomelatine D6

Acetamide-2,2,2-d3, N-[2-[7-(methoxy-d3)-1-naphthalenyl]ethyl]-

N-{2-[7-(2H?)methoxynaphthalen-1-yl]ethyl}(2H?)acetamide

Beflubutamid Impurity 4 (Bromobutide)

D6-Agomelatine

1079389-42-6