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AgoMelatine-D6

Product Name
AgoMelatine-D6
CAS No.
1079389-42-6
Chemical Name
AgoMelatine-D6
Synonyms
S-20098 D6;AgoMelatine-D6;[2H6]-Agomelatine;Beflubutamid Impurity 4 (Bromobutide);N-{2-[7-(2H?)methoxynaphthalen-1-yl]ethyl}(2H?)acetamide;Acetamide-2,2,2-d3, N-[2-[7-(methoxy-d3)-1-naphthalenyl]ethyl]-;Agomelatine D6Q: What is Agomelatine D6 Q: What is the CAS Number of Agomelatine D6 Q: What is the storage condition of Agomelatine D6 Q: What are the applications of Agomelatine D6
CBNumber
CB12646212
Molecular Formula
C15H11D6NO2
Formula Weight
249.34
MOL File
1079389-42-6.mol
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AgoMelatine-D6 Property

storage temp. 
Store at -20°C
solubility 
Methanol: soluble
form 
A solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
26447
Product name
Agomelatine-d6
Packaging
1mg
Price
$359
Updated
2024/03/01
TRC
Product number
A430003
Product name
Agomelatine-d6
Packaging
10mg
Price
$1320
Updated
2021/12/16
ChemScene
Product number
CS-0019795
Product name
AgomelatineD6
Packaging
1mg
Price
$280
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
D32833
Product name
Agomelatine-d6
Packaging
1mg
Price
$490
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0014212
Product name
AGOMELATINE-D6
Purity
95.00%
Packaging
5MG
Price
$497.17
Updated
2021/12/16
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AgoMelatine-D6 Chemical Properties,Usage,Production

Uses

Agomelatine-d6 is labelled Agomelatine (A430000) which is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively.

Biological Activity

Agomelatine-d6 is intended for use as an internal standard for the quantification of agomelatine by GC- or LC-MS. Agomelatine is an agonist of melatonin (MT) receptors and a derivative of melatonin .1 It binds to MT1 and MT2 receptors (Kis = 0.14 and 0.41 nM, respectively) and has an EC50 value of 0.1 nM in a [35S]GTPγS binding assay using CHO cells expressing MT2 receptors. Agomelatine is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B and 5-HT2C (Kis = 0.26 and 0.71 nM, respectively, for the human receptors).2 Agomelatine (40 mg/kg) inhibits the penile erection response induced by the 5-HT2 agonist Ro 60-0175 in rats. It also increases extracellular levels of noradrenaline and dopamine in the frontal cortex of freely moving rats when administered at doses ranging from 20 to 80 mg/kg. Agomelatine (10 mg/kg) reduces immobility time in the forced swim test and increases the amount of time spent in the open arms of the elevated plus maze, indicating antidepressant-like and anxiolytic-like activity, in a transgenic neuroendocrine model of depression.3 It also increases the rate of readjustment to circadian activity cycles following an induced phase shift.

References

1.Poissonnier-Durieux, S., Ettaoussi, M., Pérès, B., et al.Synthesis of 3-phenylnaphthalenic derivatives as new selective MT2 melatoninergic ligandsBioorg. Med. Chem.16(18)8339-8348(2008) 2.Millan, M.J., Gobert, A., Lejeune, F., et al.The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathwaysJ. Pharmacol. Exp. Ther.306(3)954-964(2003) 3.Barden, N., Shink, E., Labbé, M., et al.Antidepressant action of agomelatine (S 20098) in a transgenic mouse modelProg. Neuropsychopharmacol. Biol. Psychiatry29(6)908-916(2005)

AgoMelatine-D6 Preparation Products And Raw materials

Raw materials

Preparation Products

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AgoMelatine-D6 Suppliers

Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7191
Advantage
65
Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Artis Biotech Co. Ltd.
Tel
0575-18780151478 18582380095
Fax
0575-89298961
Email
sales@artisbio.com
Country
China
ProdList
2964
Advantage
58
Shanghai Champ Biopharmaceuticals Co., Ltd.
Tel
021-61537865 13585780846
Email
sales@champchem.com
Country
China
ProdList
360
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Chengdu Novel Biomedical Co., Ltd.
Tel
028-85255396 18302801538
Fax
028-85255396
Email
cdnovell@163.com
Country
China
ProdList
2310
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-037163312495,13303845143 13303845143
Fax
QQ3001379618
Email
3001379618@qq.com
Country
China
ProdList
10002
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57412
Advantage
58
Zhuzhou focus pharmaceutical technology co., LTD
Tel
+86-13776644403
Email
robert@focuspharma.cc
Country
China
ProdList
1984
Advantage
58

1079389-42-6, AgoMelatine-D6Related Search:


  • AgoMelatine-D6
  • [2H6]-Agomelatine
  • S-20098 D6
  • Agomelatine D6Q: What is Agomelatine D6 Q: What is the CAS Number of Agomelatine D6 Q: What is the storage condition of Agomelatine D6 Q: What are the applications of Agomelatine D6
  • Acetamide-2,2,2-d3, N-[2-[7-(methoxy-d3)-1-naphthalenyl]ethyl]-
  • N-{2-[7-(2H?)methoxynaphthalen-1-yl]ethyl}(2H?)acetamide
  • Beflubutamid Impurity 4 (Bromobutide)
  • 1079389-42-6