B-Raf inhibitor 1

ChemicalBook > CAS DataBase List > B-Raf inhibitor 1

Product Name: B-Raf inhibitor 1
CAS No.: 1093100-40-3
Chemical Name: B-Raf inhibitor 1
Synonyms: CS-927;or Base;B-RAFcas;Raf inhibitor 1;B-Raf inhibitor 1;BRAF inhibitor 13;B-Raf inhibitor 1 Base;B-Raf inhibitor 1, >=98%;N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine;N5-(3-(7H-purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine
CBNumber: CB12652787
Molecular Formula: C26H19ClN8
Formula Weight: 478.94
MOL File: 1093100-40-3.mol

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B-Raf inhibitor 1 Property

Boiling point:: 735.4±60.0 °C(Predicted)
Density: 1.461±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥ 47.9mg/mL in DMSO
pka: 8.41±0.10(Predicted)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Apolloscientific

Product number: BISN0223
Product name: B-Raf inhibitor 1
Packaging: 1mg
Price: $75
Updated: 2021/12/16

ApexBio Technology

Product number: B1172
Product name: B-Rafinhibitor1
Packaging: 5mg
Price: $105
Updated: 2021/12/16

ChemScene

Product number: CS-2182
Product name: Rafinhibitor1
Purity: 98.05%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

Apolloscientific

Product number: BISN0223
Product name: B-Raf inhibitor 1
Packaging: 5mg
Price: $156
Updated: 2021/12/16

ChemScene

Product number: CS-2182
Product name: Rafinhibitor1
Purity: 98.05%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

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B-Raf inhibitor 1 Chemical Properties,Usage,Production

Biological Activity

B-Raf inhibitor 1 is a potent Raf kinase inhibitor for B-RafWT, B-RafV600E, and C-Raf with Ki of 1 nM, 1 nM, and 0.3 nM, respectively.

in vitro

Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC ₅₀ s of 0.31 and 0.72 μM, respectively. Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif.

target

B-Raf

< span> 1 nM (Ki)

B-Raf ^V600E

1 nM (Ki)

c-Raf

0.3 nM (Ki )

B-Raf inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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1093100-40-3, B-Raf inhibitor 1Related Search:

(S)-(+)-Benzyl glycidyl ether Benzyl alcohol Poly(methyl methacrylate) 4'-Hydroxyacetophenone 2-Methylpropanedioic acid

B-Raf inhibitor 1

1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-

N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine

B-Raf inhibitor 1, >=98%

BRAF inhibitor 13

CS-927

B-Raf inhibitor 1 Base

or Base

1-N-(4-chlorophenyl)-6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine

Raf inhibitor 1

B-RAFcas

N5-(3-(7H-purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine

1093100-40-3

C26H19ClN8

Inhibitors