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B-Raf inhibitor 1

Product Name
B-Raf inhibitor 1
CAS No.
1093100-40-3
Chemical Name
B-Raf inhibitor 1
Synonyms
CS-927;or Base;B-RAFcas;Raf inhibitor 1;B-Raf inhibitor 1;BRAF inhibitor 13;B-Raf inhibitor 1 Base;B-Raf inhibitor 1, >=98%;N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine;N5-(3-(7H-purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine
CBNumber
CB12652787
Molecular Formula
C26H19ClN8
Formula Weight
478.94
MOL File
1093100-40-3.mol
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B-Raf inhibitor 1 Property

Boiling point:
735.4±60.0 °C(Predicted)
Density 
1.461±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥ 47.9mg/mL in DMSO
form 
Solid
pka
8.41±0.10(Predicted)
color 
Light yellow to yellow
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Apolloscientific
Product number
BISN0223
Product name
B-Raf inhibitor 1
Packaging
1mg
Price
$75
Updated
2021/12/16
ApexBio Technology
Product number
B1172
Product name
B-Rafinhibitor1
Packaging
5mg
Price
$105
Updated
2021/12/16
ChemScene
Product number
CS-2182
Product name
Rafinhibitor1
Purity
98.05%
Packaging
5mg
Price
$120
Updated
2021/12/16
Apolloscientific
Product number
BISN0223
Product name
B-Raf inhibitor 1
Packaging
5mg
Price
$156
Updated
2021/12/16
ChemScene
Product number
CS-2182
Product name
Rafinhibitor1
Purity
98.05%
Packaging
10mg
Price
$180
Updated
2021/12/16
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B-Raf inhibitor 1 Chemical Properties,Usage,Production

Biological Activity

B-Raf inhibitor 1 is a potent Raf kinase inhibitor for B-RafWT, B-RafV600E, and C-Raf with Ki of 1 nM, 1 nM, and 0.3 nM, respectively.

in vitro

Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC 50 s of 0.31 and 0.72 μM, respectively. Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif.

target

B-Raf

< span> 1 nM (Ki)

B-Raf V600E

1 nM (Ki)

c-Raf

0.3 nM (Ki )

B-Raf inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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B-Raf inhibitor 1 Suppliers

China 58 France 1 India 1 United States 9 Global 69
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

1093100-40-3, B-Raf inhibitor 1Related Search:

(S)-(+)-Benzyl glycidyl ether Benzyl alcohol Poly(methyl methacrylate) 4'-Hydroxyacetophenone 2-Methylpropanedioic acid

  • B-Raf inhibitor 1
  • 1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-
  • N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine
  • B-Raf inhibitor 1, >=98%
  • BRAF inhibitor 13
  • CS-927
  • B-Raf inhibitor 1 Base
  • or Base
  • 1-N-(4-chlorophenyl)-6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine
  • Raf inhibitor 1
  • B-RAFcas
  • N5-(3-(7H-purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine
  • 1093100-40-3
  • C26H19ClN8
  • Inhibitors