Birinapant
- Product Name
- Birinapant
- CAS No.
- 1260251-31-7
- Chemical Name
- Birinapant
- Synonyms
- CS-801;TL 32711;Birinapan;Birinapant;SMAC mimetic;TL-32711 ≥98%;Birinapant, >=98%;Birinapant (TL32711);TL 32711. Birinapant;Birinapant USP/EP/BP
- CBNumber
- CB12658183
- Molecular Formula
- C42H56F2N8O6
- Formula Weight
- 806.94
- MOL File
- 1260251-31-7.mol
Birinapant Property
- Melting point:
- >245oC (dec.)
- Boiling point:
- 1090.5±65.0 °C(Predicted)
- Density
- 1.320±0.06(20.0000℃)
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 13.99±0.46(Predicted)
- form
- Solid
- color
- White to Off-White
Safety
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19699
- Product name
- Birinapant
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 19699
- Product name
- Birinapant
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 19699
- Product name
- Birinapant
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $330
- Updated
- 2024/03/01
- Product number
- 19699
- Product name
- Birinapant
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $616
- Updated
- 2024/03/01
- Product number
- B399730
- Product name
- Birinapant
- Packaging
- 5mg
- Price
- $140
- Updated
- 2021/12/16
Birinapant Chemical Properties,Usage,Production
Description
Birinapant is a bivalent mimetic of the Diablo homolog known as second mitochondria-derived activator of caspase (Smac). It is an antagonist of cellular inhibitor of apoptosis 1 (cIAP1, or BIRC2), cIAP2 (BIRC3), and XIAP (BIRC4), binding each at nanomolar concentrations. Birinapant causes rapid cIAP1 degradation, caspase activation, PARP cleavage, and NF-κB activation in breast cancer cells. It shows in vivo antitumor activity, inducing apoptosis in several types of cancer xenografts in mice.
Uses
Birinapant is a bivalent SMAC mimetic compound antagonist of TRAF2 associated cIAP1 and cIAP2.
Definition
ChEBI: Birinapant is a dipeptide.
Enzyme inhibitor
This rotationally symmetric SMAC mimetic antagonist and anticancer agent (FW = 806.94 g/mol; CAS 1260251-31-7) targets cellular Inhibitor of Apoptosis Protein (or cIAP1; Kd of <1 nM), arguably the most potent mammalian caspase inhibitor, showing single-agent efficacy due to its panIAP antagonism and causing rapid cIAP1 degradation, caspase activation, PARP cleavage, and NF-κB activation. When administered in combination with TNF-α, Birinapant is effective against a melanoma cell line with acquired resistance to BRAF inhibitors
target
XIAP
Birinapant Preparation Products And Raw materials
Raw materials
Preparation Products
Birinapant Suppliers
- Tel
- 15901859516
- Fax
- 15901859516
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- Country
- China
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- 17625585511
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- qq:1580084073
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- China
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- 021-58170097
- info@topbiochem.com
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- China
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- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
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- China
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- 0519-85788828 13775037613
- sales@chemrenpharm.com
- Country
- China
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- 021-52996696,15000506266 15000506266
- Fax
- +86-21-52996696
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- China
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- Country
- China
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- 86-21-57758967
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- China
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- Tel
- 010-89508211 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
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- 8418
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- 55
- Tel
- +86 (531) 88811783
- Fax
- +86 (531) 55696010 QQ 1762738062
- sales@trio-pharmatech.com (International market)
- Country
- China
- ProdList
- 1856
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View Lastest Price from Birinapant manufacturers
- Product
- Birinapant 1260251-31-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26