5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)
- Product Name
- 5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)
- CAS No.
- 852391-15-2
- Chemical Name
- 5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)
- Synonyms
- Nec-1s;CS-2815;7-Cl-O-Nec1;Nec-1s(7-Cl-O-Nec1);Necrostatin-2 raceMate;Necrostatin 2 (raceMate);Necrostatin 2 racemate (Nec-1s);RIP1 Inhibitor II, 7-Cl-O-Nec-1;Necrostatin 2 racemate, 10 mM in DMSO;Necrostatin 2 racemate (Nec-1s) ，S8641
- CBNumber
- CB12662775
- Molecular Formula
- C13H12ClN3O2
- Formula Weight
- 277.71
- MOL File
- 852391-15-2.mol
5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione) Property
- Melting point:
- 173-175℃
- Density
- 1.450±0.06 g/cm3(Predicted)
- storage temp.
- +2C to +8C
- solubility
- Soluble in DMSO (up to 25 mg/ml).
- form
- Off-white to pale yellow solid
- pka
- 8.48±0.70(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5.04297
- Product name
- RIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem
- Packaging
- 10mg
- Price
- $258
- Updated
- 2023/01/07
- Product number
- 20924
- Product name
- (±)-Necrostatin-2
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 20924
- Product name
- (±)-Necrostatin-2
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- 20924
- Product name
- (±)-Necrostatin-2
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $216
- Updated
- 2024/03/01
- Product number
- 8960CC
- Product name
- Necrostatin2racemate
- Packaging
- 5mg
- Price
- $221
- Updated
- 2021/12/16
5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione) Chemical Properties,Usage,Production
Description
7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC50?= 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2?7-Cl-O-Nec1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4?7-Cl-O-Nec1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50?= 210 nM vs. EC50?= 490 nM), no non-specific cytotoxicity at high concentrations (100 μM) and reasonable pharmacokinetic characteristics when used in mice.2?7-Cl-O-Nec1 is recommended for cellular and?in vivo?use over Necrostatin-1.5
Uses
Necrostatin 1s is an inhibitor of indolamine 2,3-deoxygenase. Necrostatin 1s is a neuroprotective with potential therapeutic functions against brain ischemia.
in vivo
Necrostatin 2 racemate (Nec-1S) (6 mg/kg; i.v.; once) protects against TNF-induced systemic inflammatory response syndrome (SIRS) without sensitization effect[1].
| Animal Model: | Female C57BL/6J WT mice, SIRS model[1] |
| Dosage: | 0.6 mg/kg or 6 mg/kg |
| Administration: | Intravenous injection, once |
| Result: | Showed protective effect at 6 mg/kg. |
IC 50
RIPK1
References
[1] ALEXEI DEGTEREV. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury[J]. Nature chemical biology, 2005, 1 2: 112-119. DOI:10.1038/nchembio711
[2] XIN TENG . Structure–activity relationship study of novel necroptosis inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2005, 15 22: Pages 5039-5044. DOI:10.1016/j.bmcl.2005.07.077
[3] A DEGTEREV J Y J L Maki. Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase[J]. Cell Death and Differentiation, 2012, 20 2: 366-366. DOI:10.1038/cdd.2012.133
[4] N TAKAHASHI. Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models[J]. Cell Death & Disease, 2012, 3 11: e437-e437. DOI:10.1038/cddis.2012.176
[5] ALEXEI DEGTEREV. Addendum: Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury[J]. Nature chemical biology, 2013, 9 3: 192-192. DOI:10.1038/nchembio0313-192a
5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione) Preparation Products And Raw materials
Raw materials
Preparation Products
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