5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)

Product Name: 5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)
CAS No.: 852391-15-2
Chemical Name: 5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)
Synonyms: Nec-1s;CS-2815;7-Cl-O-Nec1;Nec-1s(7-Cl-O-Nec1);Necrostatin-2 raceMate;Necrostatin 2 (raceMate);Necrostatin 2 racemate (Nec-1s);RIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem;5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione);5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione
CBNumber: CB12662775
Molecular Formula: C13H12ClN3O2
Formula Weight: 277.71
MOL File: 852391-15-2.mol

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5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione) Property

Melting point:: 173-175℃
Density: 1.450±0.06 g/cm3(Predicted)
storage temp.: +2C to +8C
solubility: Soluble in DMSO (up to 25 mg/ml).
form: Off-white to pale yellow solid
pka: 8.48±0.70(Predicted)
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.04297
Product name: RIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem
Packaging: 10mg
Price: $258
Updated: 2023/01/07

Cayman Chemical

Product number: 20924
Product name: (±)-Necrostatin-2
Purity: ≥98%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 20924
Product name: (±)-Necrostatin-2
Purity: ≥98%
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Cayman Chemical

Product number: 20924
Product name: (±)-Necrostatin-2
Purity: ≥98%
Packaging: 10mg
Price: $216
Updated: 2024/03/01

AK Scientific

Product number: 8960CC
Product name: Necrostatin2racemate
Packaging: 5mg
Price: $221
Updated: 2021/12/16

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5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione) Chemical Properties,Usage,Production

Description

7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC50?= 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2?7-Cl-O-Nec1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4?7-Cl-O-Nec1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50?= 210 nM vs. EC50?= 490 nM), no non-specific cytotoxicity at high concentrations (100 μM) and reasonable pharmacokinetic characteristics when used in mice.2?7-Cl-O-Nec1 is recommended for cellular and?in vivo?use over Necrostatin-1.5

Uses

Necrostatin 1s is an inhibitor of indolamine 2,3-deoxygenase. Necrostatin 1s is a neuroprotective with potential therapeutic functions against brain ischemia.

References

1) Degterev?et al. (2005)?Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury; Nat. Chem. Biol.,?1?112 2) Teng?et al. (2005)?Structure-activity relationship of novel necroptosis inhibitors; Bioorg. Med. Chem. Lett.,?15?5039 3) Degterev?et al. (2012)?Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase; Cell Death Differ.,?20?366 4) Takahashi?et al. (2012)?Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models; Cell Death Dis.,?3?e437 5) Degterev?et al. (2013)?Addendum: Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury; Nat. Chem. Biol.,?9?192

5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione) Preparation Products And Raw materials

Raw materials

Preparation Products

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5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione) Suppliers

China 82 United States 12 Global 94

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852391-15-2, 5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)Related Search:

TYRPHOSTIN AG 1296 GW441756 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- SU 4312

5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)

5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione

Necrostatin 2 (raceMate)

Necrostatin-2 raceMate

2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-

5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione

Nec-1s(7-Cl-O-Nec1)

RIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem

Nec-1s

CS-2815

7-Cl-O-Nec1

Nec-1S,Nec-1,Necrostatin 1S,inhibit,necroptosis,necrostatin,Necrostatin 2,Receptor-interacting protein kinases,Necrostatin-2,Necrostatin2,Necrostatin 2 racemate,IDO,Inhibitor,stable,RIPK1,RIP kinase,RIPK

Necrostatin 2 racemate (Nec-1s)

852391-15-2