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CP 809101 hydrochloride

Product Name
CP 809101 hydrochloride
CAS No.
1215721-40-6
Chemical Name
CP 809101 hydrochloride
Synonyms
CP-809101 HCl;CP809101 HYDROCHLORIDE;CP 809101 HYDROCHLORIDE;2-[(3-chlorophenyl)methoxy]-6-piperazin-1-ylpyrazine;2-((3-Chlorobenzyl)oxy)-6-(piperazin-1-yl)pyrazine hydrochloride;2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine hydrochloride (1:1);CP 809101 hydrochloride,hyperactivity,nicotine dependence,Inhibitor,nicotine,antipsychotic,inhibit,CP-809101,Serotonin Receptor,5-HT Receptor,CP809101,conditioned avoidance responding,CP 809101,CP809101 hydrochloride,5-hydroxytryptamine Receptor
CBNumber
CB12666612
Molecular Formula
C15H18Cl2N4O
Formula Weight
341.23562
MOL File
1215721-40-6.mol
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CP 809101 hydrochloride Property

storage temp. 
Store at -20°C
solubility 
H2O : 20 mg/mL (58.61 mM; Need ultrasonic)
form 
Powder
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C781443
Product name
CP809101Hydrochloride
Packaging
2.5mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC64988
Product name
CP 809101 hydrochloride
Packaging
50mg
Price
$298
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC64988
Product name
CP 809101 hydrochloride
Packaging
10mg
Price
$85
Updated
2021/12/16
ChemScene
Product number
CS-1221
Product name
CP-809101hydrochloride
Purity
99.83%
Packaging
10mg
Price
$134
Updated
2021/12/16
AK Scientific
Product number
2524DN
Product name
2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazinehydrochloride
Packaging
10mg
Price
$164
Updated
2021/12/16
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CP 809101 hydrochloride Chemical Properties,Usage,Production

Uses

CP-809101 hydrochloride is a potent and highly selective 5-HT2C receptor agonist, with pEC50s of 9.96, 7.19 and 6.81 M for human 5HT2C, 5HT2B and 5HT2A receptor. CP-809101 hydrochloride inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 hydrochloride also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence[1][2].

in vivo

CP-809101 hydrochloride (0.1-56 mg/kg; s.c.; single) inhibits the conditioned avoidance response of rats in a dose-dependent manner[1].
CP-809101 hydrochloride (0.56, 1.78, 5.6, 17.8 mg/kg; s.c.; single) antagonizes PCP (phencyclidine hydrochloride)-induced and d-amphetamine-induced hyperactivity (the latter in a dose-dependent manner)[1].
CP-809101 hydrochloride (0.56, 1.78, 5.6, 17.8 mg/kg; s.c.; single) dose-dependently decreases spontaneous locomotor activity with an ED50 value of 2.2 mg/kg[1].
CP-809101 hydrochloride (0.3, 1, 3 mg/kg; s.c.; single) reduces responding for both nicotine and food and blocked the discriminative stimulus properties of nicotine[2].

Animal Model:Male CF rats (conditioned avoidance responding (CAR) model)[1].
Dosage:0.1-56 mg/kg
Administration:Subcutaneous injection; single.
Result:Resulted in a dose-dependent inhibition of the conditioned avoidance response with an ID50 value of 4.8 mg/kg.
Animal Model:Male CD rats (PCP or d-amphetamine-induced hyperactivity model)[1].
Dosage:0.56, 1.78, 5.6, 17.8 mg/kg
Administration:Subcutaneous injection; single.
Result:Antagonized PCP-induced hyperactivity, with an ED50 value of 2.4 mg/kg.
Antagonized d-amphetamine-induced hyperactivity, with an ED50 value of 2.7 mg/kg, and in a dose-dependent manner.
Animal Model:Male CD rats (spontaneous locomotor model)[1].
Dosage:0.56, 1.78, 5.6, 17.8 mg/kg
Administration:Subcutaneous injection; single.
Result:Inhibited spontaneous locomotor activity in a dose-dependent manner (ED50=2.7 mg/kg).
Animal Model:Adult male Sprague-Dawley rats (280-400 g)[2].
Dosage:0.3, 1, 3 mg/kg
Administration:Subcutaneous injection; single.
Result:Produced a dose-related decrease in responding for food and nicotine self-administration in rats.

IC 50

5-HT2C Receptor: 9.96 (pEC50); 5-HT2B Receptor: 7.19 (pEC50); 5-HT2A Receptor: 6.81 (pEC50)

storage

Desiccate at RT

References

[1] Siuciak JA, et al. CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity. Neuropharmacology. 2007 Feb;52(2):279-90. DOI:10.1016/j.neuropharm.2006.07.024
[2] Higgins GA, et al. Evaluation of chemically diverse 5-HT?c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles. Psychopharmacology (Berl). 2013 Apr;226(3):475-90. DOI:10.1007/s00213-012-2919-2

CP 809101 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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CP 809101 hydrochloride Suppliers

China 41 United Kingdom 2 United States 10 Global 53
Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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info@chemexpress.com
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China
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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LETOPHARM LIMITED
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+86-21-5821 5861
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+86-21-5106 2861
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sales@letopharm.com
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China
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SPIRO PHARMA
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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Guangzhou QiYun Biotechnology Co., Ltd.
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020-61288194 61288195
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505721671@qq.com
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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MQ (shanghai) Pharmaceuticals Co., Ltd.
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13761635123
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1014988033@qq.com
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Musechem
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+1-800-259-7612
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United States
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