ChemicalBook > CAS DataBase List > CP 809101 hydrochloride

CP 809101 hydrochloride

Product Name
CP 809101 hydrochloride
CAS No.
1215721-40-6
Chemical Name
CP 809101 hydrochloride
Synonyms
CP-809101 HCl;CP809101 HYDROCHLORIDE;CP 809101 HYDROCHLORIDE;2-[(3-chlorophenyl)methoxy]-6-piperazin-1-ylpyrazine;2-((3-Chlorobenzyl)oxy)-6-(piperazin-1-yl)pyrazine hydrochloride;2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine hydrochloride (1:1);CP 809101 hydrochloride,hyperactivity,nicotine dependence,Inhibitor,nicotine,antipsychotic,inhibit,CP-809101,Serotonin Receptor,5-HT Receptor,CP809101,conditioned avoidance responding,CP 809101,CP809101 hydrochloride,5-hydroxytryptamine Receptor
CBNumber
CB12666612
Molecular Formula
C15H18Cl2N4O
Formula Weight
341.23562
MOL File
1215721-40-6.mol
More
Less

CP 809101 hydrochloride Property

storage temp. 
Store at -20°C
solubility 
H2O : 20 mg/mL (58.61 mM; Need ultrasonic)
form 
Powder
color 
Light yellow to yellow
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
C781443
Product name
CP809101Hydrochloride
Packaging
2.5mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC64988
Product name
CP 809101 hydrochloride
Packaging
10mg
Price
$85
Updated
2021/12/16
ChemScene
Product number
CS-1221
Product name
CP-809101hydrochloride
Purity
99.83%
Packaging
10mg
Price
$134
Updated
2021/12/16
AK Scientific
Product number
2524DN
Product name
2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazinehydrochloride
Packaging
10mg
Price
$164
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC64988
Product name
CP 809101 hydrochloride
Packaging
50mg
Price
$298
Updated
2021/12/16
More
Less

CP 809101 hydrochloride Chemical Properties,Usage,Production

Uses

CP-809101 hydrochloride is a potent and highly selective 5-HT2C receptor agonist, with pEC50s of 9.96, 7.19 and 6.81 M for human 5HT2C, 5HT2B and 5HT2A receptor. CP-809101 hydrochloride inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 hydrochloride also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence[1][2].

in vivo

CP-809101 hydrochloride (0.1-56 mg/kg; s.c.; single) inhibits the conditioned avoidance response of rats in a dose-dependent manner[1].
CP-809101 hydrochloride (0.56, 1.78, 5.6, 17.8 mg/kg; s.c.; single) antagonizes PCP (phencyclidine hydrochloride)-induced and d-amphetamine-induced hyperactivity (the latter in a dose-dependent manner)[1].
CP-809101 hydrochloride (0.56, 1.78, 5.6, 17.8 mg/kg; s.c.; single) dose-dependently decreases spontaneous locomotor activity with an ED50 value of 2.2 mg/kg[1].
CP-809101 hydrochloride (0.3, 1, 3 mg/kg; s.c.; single) reduces responding for both nicotine and food and blocked the discriminative stimulus properties of nicotine[2].

Animal Model:Male CF rats (conditioned avoidance responding (CAR) model)[1].
Dosage:0.1-56 mg/kg
Administration:Subcutaneous injection; single.
Result:Resulted in a dose-dependent inhibition of the conditioned avoidance response with an ID50 value of 4.8 mg/kg.
Animal Model:Male CD rats (PCP or d-amphetamine-induced hyperactivity model)[1].
Dosage:0.56, 1.78, 5.6, 17.8 mg/kg
Administration:Subcutaneous injection; single.
Result:Antagonized PCP-induced hyperactivity, with an ED50 value of 2.4 mg/kg.
Antagonized d-amphetamine-induced hyperactivity, with an ED50 value of 2.7 mg/kg, and in a dose-dependent manner.
Animal Model:Male CD rats (spontaneous locomotor model)[1].
Dosage:0.56, 1.78, 5.6, 17.8 mg/kg
Administration:Subcutaneous injection; single.
Result:Inhibited spontaneous locomotor activity in a dose-dependent manner (ED50=2.7 mg/kg).
Animal Model:Adult male Sprague-Dawley rats (280-400 g)[2].
Dosage:0.3, 1, 3 mg/kg
Administration:Subcutaneous injection; single.
Result:Produced a dose-related decrease in responding for food and nicotine self-administration in rats.

IC 50

5-HT2C Receptor: 9.96 (pEC50); 5-HT2B Receptor: 7.19 (pEC50); 5-HT2A Receptor: 6.81 (pEC50)

storage

Desiccate at RT

References

[1] Siuciak JA, et al. CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity. Neuropharmacology. 2007 Feb;52(2):279-90. DOI:10.1016/j.neuropharm.2006.07.024
[2] Higgins GA, et al. Evaluation of chemically diverse 5-HT?c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles. Psychopharmacology (Berl). 2013 Apr;226(3):475-90. DOI:10.1007/s00213-012-2919-2

CP 809101 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CP 809101 hydrochloride Suppliers

China 41 United Kingdom 2 United States 10 Global 53
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1215721-40-6, CP 809101 hydrochlorideRelated Search:

4-Methoxyphenylacetone Cinnamyl alcohol 1-(2-BROMOPHENYL)-2-THIOUREA 4-Methoxybenzylchloride 3-Chloropropionyl chloride

  • 2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine hydrochloride (1:1)
  • CP809101 HYDROCHLORIDE;CP 809101 HYDROCHLORIDE
  • CP-809101 HCl
  • 2-[(3-chlorophenyl)methoxy]-6-piperazin-1-ylpyrazine
  • CP 809101 hydrochloride,hyperactivity,nicotine dependence,Inhibitor,nicotine,antipsychotic,inhibit,CP-809101,Serotonin Receptor,5-HT Receptor,CP809101,conditioned avoidance responding,CP 809101,CP809101 hydrochloride,5-hydroxytryptamine Receptor
  • 2-((3-Chlorobenzyl)oxy)-6-(piperazin-1-yl)pyrazine hydrochloride
  • 1215721-40-6
  • C15H17ClN4OHCl