OTSSP 167 hydrochloride

Product Name: OTSSP 167 hydrochloride
CAS No.: 1431697-89-0
Chemical Name: OTSSP 167 hydrochloride
Synonyms: OTS167;CS-1832;CS-1147;OTSSP167;OTSSP 167;OTSSP-167;MELK inhibitor;OTSSP167 (OTS167);OTSSP167 (CS-1147);OTSSP167 (Free base)
CBNumber: CB12666672
Molecular Formula: C25H28Cl2N4O2
Formula Weight: 487.42
MOL File: 1431697-89-0.mol

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OTSSP 167 hydrochloride Property

storage temp.: Store at -20°C
solubility: insoluble in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: O713000
Product name: OTSSP167
Packaging: 2.5mg
Price: $165
Updated: 2021/12/16

AK Scientific

Product number: 2618AH
Product name: 1-(8-((1R,4R)-4-((Dimethylamino)methyl)cyclohexylamino)-2-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-7-yl)ethanone
Packaging: 2mg
Price: $232
Updated: 2021/12/16

ApexBio Technology

Product number: B1321
Product name: OTSSP167
Packaging: 10mg
Price: $240
Updated: 2021/12/16

AK Scientific

Product number: 2618AH
Product name: 1-(8-((1R,4R)-4-((Dimethylamino)methyl)cyclohexylamino)-2-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-7-yl)ethanone
Packaging: 10mg
Price: $424
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BO170790
Product name: OTS 167
Packaging: 50mg
Price: $472.5
Updated: 2021/12/16

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OTSSP 167 hydrochloride Chemical Properties,Usage,Production

Uses

OTSSP167 is a highly potent MELK (maternal embryonic leucine zipper kinase) inhibitor.

Definition

ChEBI: 4-[7-acetyl-8-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1H-1,5-naphthyridin-2-ylidene]-2,6-dichloro-1-cyclohexa-2,5-dienone is a naphthyridine derivative.

Biological Activity

otssp167 is an inhibitor of maternal embryonic leucine zipper kinase (melk) with ic50 value of 0.41nm [1].melk is a member of the ampk serine/threonine kinase family and is involved in the mammalian embryonic development. it plays roles in cancer cell growth and formation or maintenance of cancer stem cells. otssp167 is a small-molecule inhibitor and can inhibit melk’s activity effectively and selectively. otssp167 inhibits cell proliferation of a variety of cancer cell lines including a549, t47d, du4475 and 22rv1. the ic50 values are 6.7nm, 4.3nm, 2.3nm and 6nm, respectively. in mice bearing mda-mb-231 xenograft, administration of otssp167 inhibits 70% tumor growth at dose of 20 mg/kg. besides that, otssp167 is also found to have effects on psma1 and dbnl which are the novel substrates of melk. it inhibits the phosphorylation of psma1 and dbnl causes the subsequent suppression of mammosphere formation [1].

target

MELK

References

[1] chung s, suzuki h, miyamoto t, et al. development of an orally-administrative melk-targeting inhibitor that suppresses the growth of various types of human cancer. oncotarget, 2012, 3(12): 1629.

OTSSP 167 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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OTSSP 167 hydrochloride Suppliers

China 61 India 1 United States 9 Global 71

Shanghai Boyle Chemical Co., Ltd.

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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
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MedChemexpress LLC

Tel: 021-58955995
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Email: sales@medchemexpress.cn
Country: United States
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CEG Chemical Science&Technology Co., Ltd.

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AdooQ Bioscience CHINA

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Shanghai Lollane Biological Technology Co.,Ltd.

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D&C Chemicals

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SPIRO PHARMA

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Twochem Co.Ltd

Tel: 021-021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 304
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View Lastest Price from OTSSP 167 hydrochloride manufacturers

Career Henan Chemical Co

Product: OTSSP167 1431697-89-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

1431697-89-0, OTSSP 167 hydrochlorideRelated Search:

Dichloroethane Thionyl chloride Xylene Bortezomib Selumetinib VE-821 Crizotinib AZD-9291 Olaparib

MELK inhibitor

OTSSP 167 hydrochloride

OTSSP167 (hydrochloride)

OTSSP-167 hydrochloride

OTSSP 167

OTSSP167

OTSSP-167

CS-1832

1-(8-((1R,4R)-4-((Dimethylamino)methyl)cyclohexylamino)-2-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-7-yl)ethanone

OTSSP167 (CS-1147)

OTSSP167 (Free base)

CS-1147

1-[6-(3,5-Dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-ethanone

OTS167

1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((1r,4r)-4-((dimethylamino)methyl)cyclohexylamino)-1,5-naphthyridin-3-yl)ethanone

1-[6-(3,5-Dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-ethanone OTSSP167 hcl

Ethanone, 1-[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-

OTSSP167 (OTS167)

inhibit,Maternal embryonic leucine zipper kinase,OTS 167,Inhibitor,OTS-167,MELK,OTSSP167,OTSSP 167,OTSSP-167

1431697-89-0

C25H28Cl2N4O2

Inhibitors

API