OTSSP 167 hydrochloride
- Product Name
- OTSSP 167 hydrochloride
- CAS No.
- 1431697-89-0
- Chemical Name
- OTSSP 167 hydrochloride
- Synonyms
- OTS167;CS-1832;CS-1147;OTSSP167;OTSSP 167;OTSSP-167;MELK inhibitor;OTSSP167 (OTS167);OTSSP167 (CS-1147);OTSSP167 (Free base)
- CBNumber
- CB12666672
- Molecular Formula
- C25H28Cl2N4O2
- Formula Weight
- 487.42
- MOL File
- 1431697-89-0.mol
OTSSP 167 hydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- insoluble in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
N-Bromosuccinimide Price
- Product number
- O713000
- Product name
- OTSSP167
- Packaging
- 2.5mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 2618AH
- Product name
- 1-(8-((1R,4R)-4-((Dimethylamino)methyl)cyclohexylamino)-2-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-7-yl)ethanone
- Packaging
- 2mg
- Price
- $232
- Updated
- 2021/12/16
- Product number
- B1321
- Product name
- OTSSP167
- Packaging
- 10mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 2618AH
- Product name
- 1-(8-((1R,4R)-4-((Dimethylamino)methyl)cyclohexylamino)-2-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-7-yl)ethanone
- Packaging
- 10mg
- Price
- $424
- Updated
- 2021/12/16
- Product number
- BO170790
- Product name
- OTS 167
- Packaging
- 50mg
- Price
- $472.5
- Updated
- 2021/12/16
OTSSP 167 hydrochloride Chemical Properties,Usage,Production
Uses
OTSSP167 is a highly potent MELK (maternal embryonic leucine zipper kinase) inhibitor.
Definition
ChEBI: 4-[7-acetyl-8-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1H-1,5-naphthyridin-2-ylidene]-2,6-dichloro-1-cyclohexa-2,5-dienone is a naphthyridine derivative.
Biological Activity
otssp167 is an inhibitor of maternal embryonic leucine zipper kinase (melk) with ic50 value of 0.41nm [1].melk is a member of the ampk serine/threonine kinase family and is involved in the mammalian embryonic development. it plays roles in cancer cell growth and formation or maintenance of cancer stem cells. otssp167 is a small-molecule inhibitor and can inhibit melk’s activity effectively and selectively. otssp167 inhibits cell proliferation of a variety of cancer cell lines including a549, t47d, du4475 and 22rv1. the ic50 values are 6.7nm, 4.3nm, 2.3nm and 6nm, respectively. in mice bearing mda-mb-231 xenograft, administration of otssp167 inhibits 70% tumor growth at dose of 20 mg/kg. besides that, otssp167 is also found to have effects on psma1 and dbnl which are the novel substrates of melk. it inhibits the phosphorylation of psma1 and dbnl causes the subsequent suppression of mammosphere formation [1].
target
MELK
References
[1] chung s, suzuki h, miyamoto t, et al. development of an orally-administrative melk-targeting inhibitor that suppresses the growth of various types of human cancer. oncotarget, 2012, 3(12): 1629.
OTSSP 167 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
OTSSP 167 hydrochloride Suppliers
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View Lastest Price from OTSSP 167 hydrochloride manufacturers
- Product
- OTSSP167 1431697-89-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10