ChemicalBook > CAS DataBase List > KU 0060648

KU 0060648

Product Name: KU 0060648
CAS No.: 881375-00-4
Chemical Name: KU 0060648
Synonyms: CS-768;ku-0060648;KU 0060648;KU-0060648 ，S8045;KU0060648;KU 0060648;KU 0060648 USP/EP/BP;KU 0060648 trihydrochloride;KU-0060648 DNA-PK inhibitor Axon2604 Axon-2604 KU0060648;2-(4-ethylpiperazin-1-yl)-N-[4-(2-morpholin-4-yl-4-oxochromen-8-yl)dibenzothiophen-1-yl]acetamide;4-Ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide
CBNumber: CB12667538
Molecular Formula: C33H34N4O4S
Formula Weight: 582.71
MOL File: 881375-00-4.mol

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KU 0060648 Property

Boiling point:: 819.9±65.0 °C(Predicted)
Density: 1.337±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Limited solubility, soluble in HCl
form: Powder
pka: 14.10±0.43(Predicted)
color: Off-white to brown
InChIKey: AATCBLYHOUOCTO-UHFFFAOYSA-N
SMILES: N1(CC(NC2=C3C4=CC=CC=C4SC3=C(C3=C4OC(N5CCOCC5)=CC(=O)C4=CC=C3)C=C2)=O)CCN(CC)CC1
CAS DataBase Reference: 881375-00-4

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1257
Product name: KU-0060648
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $178
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1257
Product name: KU-0060648
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $712
Updated: 2025/07/31

Cayman Chemical

Product number: 15344
Product name: Ku-0060648
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 15344
Product name: Ku-0060648
Purity: ≥98%
Packaging: 5mg
Price: $142
Updated: 2024/03/01

Cayman Chemical

Product number: 15344
Product name: Ku-0060648
Purity: ≥98%
Packaging: 10mg
Price: $266
Updated: 2024/03/01

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KU 0060648 Chemical Properties,Usage,Production

Uses

KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ.

Definition

ChEBI: 2-(4-ethyl-1-piperazinyl)-N-[4-[2-(4-morpholinyl)-4-oxo-1-benzopyran-8-yl]-1-dibenzothiophenyl]acetamide is a member of dibenzothiophenes.

Biological Activity

KU-0060648 is a very potent dual inhibitor of DNA-PK and PI3K. The IC50 values for inhibition of DNA-PK in MCF7 and SW620 cells are 19 and 170 nM, respectively. The compound KU-0060648 inhibits MCF7 PI3K activity with an IC50 of 39 nM, but is inactive against PI3K in SW620, suggesting a cell-dependent mechanism of inhibition. KU-0060648 increases sensitivity to DNA damaging cytotoxic drugs such as etoposide and doxorubicin in tumor cell lines expressing DNA-PK. KU-0060648 stimulates Cas9 (CRISPR associated protein 9) mediated genome editing by enhancing the rate of homology directed-repair (HDR) and decreasing the rate of NHEJ (non-homologous end-joining).', 'KU-0060648 is observed to inhibit proliferation and initiate apoptosis in hepatocellular carcinoma. KU-0060648 is useful in chemotherapy as it increases the efficiency of double stranded breaks initiated by anticancer drugs.

in vivo

KU-0060648 (intraperitoneal injection; 10 and 50 mg/kg; once daily; daily for 21 days) dramatically inhibits HepG2 xenograft growth in nude mice, the tumor weights (at week 5) of KU-0060648 group mice are dramatically lighter than that of vehicle control mice and exert a dose-dependent effect in vivo^[1].

Animal Model:	HepG2 xenograft nude mice model^[1]
Dosage:	10 and 50 mg/kg
Administration:	Intraperitoneal injection; 10 and 50 mg/kg; once daily; daily for 21 days
Result:	Suppressed HepG2 xenograft growth in nude mice.

IC 50

PI3Kα: 4 nM (IC₅₀); PI3Kβ: 0.5 nM (IC₅₀); PI3Kγ: 0.594 μM (IC₅₀); PI3Kδ: 0.1 nM (IC₅₀); DNA-PK: 8.6 nM (IC₅₀)

storage

Store at -20°C

KU 0060648 Preparation Products And Raw materials

Raw materials

Preparation Products

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KU 0060648 Suppliers

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881375-00-4, KU 0060648Related Search:

NU7441 (KU-57788) NU7026 MK-8776 (SCH 900776) Zidovudine Rapamycin Olaparib

4-Ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide

1-Piperazineacetamide, 4-ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-

2-(4-Ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide

KU 0060648 trihydrochloride

CS-768

KU0060648;KU 0060648

KU 0060648

ku-0060648

KU 0060648 USP/EP/BP

KU-0060648 DNA-PK inhibitor Axon2604 Axon-2604 KU0060648

2-(4-ethylpiperazin-1-yl)-N-[4-(2-morpholin-4-yl-4-oxochromen-8-yl)dibenzothiophen-1-yl]acetamide

2-(4-Ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide , KU-0060648

KU-0060648 ，S8045

881375-00-4

Akt

mTOR

PI3K