((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone

Product Name: ((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone
CAS No.: 1103738-19-7
Chemical Name: ((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone
Synonyms: SOTA-005;EOS-61383;LX-4211 int;6aS)-6-hydroxy-2;LX-4211 inermediate;LX-4211 intermediate;2-dimethyltetrahydrofuro[2;D-xylo-Pentodialdo-5,2-furanose;3]dioxol-5-yl)(morpholino)methanone;LX-4211 intermediate, 10 mM in DMSO
CBNumber: CB12668005
Molecular Formula: C12H19NO6
Formula Weight: 273.28
MOL File: 1103738-19-7.mol

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((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone Property

Boiling point:: 479.3±45.0 °C(Predicted)
Density: 1.318±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: 12.78±0.60(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C12H19NO6/c1-12(2)18-9-7(14)8(17-11(9)19-12)10(15)13-3-5-16-6-4-13/h7-9,11,14H,3-6H2,1-2H3/t7-,8-,9+,11+/m1/s1
InChIKey: ZHDDJWFZDNKWIC-REIXXSIJSA-N
SMILES: O=C(N1CCOCC1)[C@H]1[C@H]([C@H]2[C@@]([H])(O1)OC(O2)(C)C)O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-M2126
Product name: D-xylo-Pentodialdo-5,2-furanose,4,5-O-(1-methylethylidene)-1-C-4-morpholinyl-,(5S)-
Purity: 99.88%
Packaging: 100mg
Price: $68
Updated: 2021/12/16

ChemScene

Product number: CS-M2126
Product name: D-xylo-Pentodialdo-5,2-furanose,4,5-O-(1-methylethylidene)-1-C-4-morpholinyl-,(5S)-
Purity: 99.88%
Packaging: 250mg
Price: $111
Updated: 2021/12/16

ChemScene

Product number: CS-M2126
Product name: D-xylo-Pentodialdo-5,2-furanose,4,5-O-(1-methylethylidene)-1-C-4-morpholinyl-,(5S)-
Purity: 99.88%
Packaging: 1g
Price: $187
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CRB0006511
Product name: D-XYLO-PENTODIALDO-5,2-FURANOSE, 4,5-O-(1-METHYLETHYLIDENE)-1-C-4-MORPHOLINYL-,(5S)-
Purity: 95.00%
Packaging: 5MG
Price: $499.43
Updated: 2021/12/16

ChemScene

Product number: CS-M2126
Product name: D-xylo-Pentodialdo-5,2-furanose,4,5-O-(1-methylethylidene)-1-C-4-morpholinyl-,(5S)-
Purity: 99.88%
Packaging: 5g
Price: $562
Updated: 2021/12/16

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((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone Chemical Properties,Usage,Production

Synthesis

To a solution of (3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylic acid (5.0 g, 24.5 mmol) in THF (100 ML, 20.x.) was added TBTU (11.8 g, 1.5 equiv), N-methylmorpholine (NMM, 4.1 mL, 1.5 equiv) and the mixture was stirred at 20° C. for 30 min. Morpholine (3.2 mL, 1.5 equiv) was added, and the reaction mixture was stirred at 20° C. for an additional 6h. The solid was filtered off by filtration, and the cake was washed with THF (10 mL, 2.x. .x.2). The organic solution was concentrated under a vacuum. The residue was purified by silica gel column chromatography (hexanes: EtOAc, from 1:4 to 4: 1) to afford 4.3 g of the desired morpholine amide (((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone) as a white solid.

References

[1] Patent: US2009/30198, 2009, A1. Location in patent: Page/Page column 8
[2] Patent: US2010/16422, 2010, A1. Location in patent: Page/Page column 4
[3] Patent: EP2332947, 2011, A1. Location in patent: Page/Page column 6-7
[4] Patent: EP2661256, 2018, B1. Location in patent: Paragraph 0091
[5] Patent: CN106892948, 2017, A. Location in patent: Paragraph 0195; 0196; 0197; 0198

((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone Preparation Products And Raw materials

Raw materials

Preparation Products

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((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone Suppliers

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View Lastest Price from ((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: D-xylo-Pentodialdo-5,2-furanose, 4,5-O-(1-Methylethylidene)-1-C-4-Morpholinyl-,(5S)- 1103738-19-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

Nanjing Fred Technology Co., Ltd

Product: ((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone 1103738-19-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2024-01-04

Hangzhou ICH Biofarm Co., Ltd

Product: (3aS,5R,6S,6aS)-[6-hydroxy-2,2-dimethyltetrahydrofuro[3,2-d][1,3]dioxol-5-yl]-(morpholino)methanone 1103738-19-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200kg
Release date: 2023-06-30

1103738-19-7, ((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanoneRelated Search:

MK-4618 Pyrimidinone Acid Sodium Salt (6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-methylethyl)silyl]oxy]-5H-cyclohepta[b]pyridin-5-one

D-xylo-Pentodialdo-5,2-furanose, 4,5-O-(1-Methylethylidene)-1-C-4-Morpholinyl-,(5S)-

((3aS,5R,6S,6aS)-6-hydroxy-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(Morpholino)Methanone

(3aS,5R,6S,6aS)-[6-hydroxy-2,2-dimethyltetrahydrofuro[3,2-d][1,3]dioxol-5-yl]-(morpholino)methanone

LX-4211 int

(5S)-4,5-O-(1-Methylethylidene)-1-C-4-morpholinyl-D-xylo-pentodialdo-5,2-furanose

LX-4211 inermediate

EOS-61383

SOTA-005

((3aS,5S,6R,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone

LX-4211 intermediate

[(3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]-morpholin-4-ylmethanone

2-dimethyltetrahydrofuro[2

3]dioxol-5-yl)(morpholino)methanone

6aS)-6-hydroxy-2

((3aS,5R,6S,6aS)-6-hydroxy-2,2-diMethyltetrahydrofuro[2,3-d]...

D-xylo-Pentodialdo-5,2-furanose

(5S)-4,5-o-(1-Methylethylidene)-1-C-morpholin-4-yl-D-xylo-pentodialdo-5,2-furanose

(5S)-4,5-0-(1-Methylethylidene)-1-C-4- morpholinyl-D-xylo-pentodialdo-5,2-furanose

LX-4211 intermediate, 10 mM in DMSO

((3aS,5R,6S,6aS)-6-Hydroxy-2,2-dimethyl-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholin-4-yl)methanone

1103738-19-7