ChemicalBook > CAS DataBase List > SR9011
SR9011
Biochem/physiol Actions- Product Name
- SR9011
- CAS No.
- 1379686-29-9
- Chemical Name
- SR9011
- Synonyms
- SR9001;SR9011;CS-2028;SR-90011;SR-9011;SR 9011;Stenabolic Sr9011;SR9011 Sarms powder;SR-9011;SR 9011;SR9011;White Powder SR9011Cas# 1379686-29-9 Raw Chemical Material;Trifunctional Methacrylate Monomer Sarm Steroids Powder Sr9011
- CBNumber
- CB12672925
- Molecular Formula
- C23H31ClN4O3S
- Formula Weight
- 479.04
- MOL File
- 1379686-29-9.mol
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SR9011 Property
- Boiling point:
- 642.8±50.0 °C(Predicted)
- Density
- 1.254±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 14.71±0.40(Predicted)
- color
- Dark Yellow to Very Dark Brown
- InChI
- InChI=1S/C23H31ClN4O3S/c1-2-3-4-12-25-23(29)27-13-11-19(16-27)15-26(14-18-5-7-20(24)8-6-18)17-21-9-10-22(32-21)28(30)31/h5-10,19H,2-4,11-17H2,1H3,(H,25,29)
- InChIKey
- PPUYOYQTTWJTIU-UHFFFAOYSA-N
- SMILES
- N1(C(NCCCCC)=O)CCC(CN(CC2=CC=C(Cl)C=C2)CC2SC([N+]([O-])=O)=CC=2)C1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 11930
- Product name
- SR 9011
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $93
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 11930
- Product name
- SR 9011
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $384
- Updated
- 2024/03/01
TRC
- Product number
- S684260
- Product name
- SR9011
- Packaging
- 25mg
- Price
- $2180
- Updated
- 2021/12/16
AK Scientific
- Product number
- 4689DN
- Product name
- SR-9011
- Packaging
- 5mg
- Price
- $525
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B1768
- Product name
- SR9011
- Packaging
- 2mg
- Price
- $126
- Updated
- 2021/12/16
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SR9011 Chemical Properties,Usage,Production
Biochem/physiol Actions
SR9011 is a potent nuclear receptor REV-ERB agonist (EC50 of REV-ERBα- and REV-ERBβ-dependent repressor activity = 790 and 560 nM, respectively, by cell-based reporter assay) that stimulates REV-ERB-dependent target genes suppression both in cultures in vitro and in mice in vivo (100 mg/kg i.p., b.i.d.) without activity toward a panel of 46 other nuclear receptors. SR9011 is shown to modulate circadian behavior by suppressing the transcription factors BMAL1 (brain and muscle ARNT-like protein 1) and CLOCK (circadian locomotor output cycles kaput) as well as induce energy expenditure and weight loss by regulating genes involved in lipid and glucose metabolism in mice in vivo with good bioavailabiilty (plasma conc. = 0.53 and 15.3 μM 2 hr post 10 or 100 mg/kg i.p. dosage; brain conc. = 0.24 μM 2 hr post 10 mg/kg i.p.), while its structure analog GSK4112 shows no plasma exposure.
Uses
SR 9011 is a synthetic REV-ERBα/β agonist with activity in vivo. It is a lead compound for a new class of cancer drugs associated with the body’s circadian clock.
Application
SR9011 has been used as a nuclear receptor subfamily 1 group D member 1 (NR1D1) receptor agonist:
to study its effects on microglial immune-metabolism
to study its effects on insulin secretion from human type 2 diabetes islet cells
to study its effects on thyroid-stimulating hormone β (TSHβ) gene expression
Side effects
After a close investigation of the effects of SR9011 on humans, it is deduced that the drug is well tolerated without any significant side effects. However, minor effects on sleep, such as transient insomnia, were reported by some users. Nevertheless, it is always best to stick to the given drug dose if you don’t want to experience any harm.
SR9011 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SR9011 manufacturers
Dorne Chemical Technology co. LTD
- Product
- SR9011 1379686-29-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2024-03-26
hebei hongtan Biotechnology Co., Ltd
- Product
- SR9011 1379686-29-9
- Price
- US $90.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 1000
- Release date
- 2024-03-21
Wuhan Nutra Biotechnology Co.,Ltd
- Product
- SR9011 1379686-29-9
- Price
- US $250.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10kgs
- Release date
- 2021-12-06
1379686-29-9, SR9011Related Search:
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Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]-
N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
SR9009
SR-9243
N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine