SR9011

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Biochem/physiol Actions

Product Name: SR9011
CAS No.: 1379686-29-9
Chemical Name: SR9011
Synonyms: SR9001;SR9011;CS-2028;SR-90011;SR-9011;SR 9011;Stenabolic Sr9011;SR9011 Sarms powder;SR-9011;SR 9011;SR9011;White Powder SR9011Cas# 1379686-29-9 Raw Chemical Material;Trifunctional Methacrylate Monomer Sarm Steroids Powder Sr9011
CBNumber: CB12672925
Molecular Formula: C23H31ClN4O3S
Formula Weight: 479.04
MOL File: 1379686-29-9.mol

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SR9011 Property

Boiling point:: 642.8±50.0 °C(Predicted)
Density: 1.254±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 14.71±0.40(Predicted)
color: Dark Yellow to Very Dark Brown
InChI: InChI=1S/C23H31ClN4O3S/c1-2-3-4-12-25-23(29)27-13-11-19(16-27)15-26(14-18-5-7-20(24)8-6-18)17-21-9-10-22(32-21)28(30)31/h5-10,19H,2-4,11-17H2,1H3,(H,25,29)
InChIKey: PPUYOYQTTWJTIU-UHFFFAOYSA-N
SMILES: N1(C(NCCCCC)=O)CCC(CN(CC2=CC=C(Cl)C=C2)CC2SC([N+]([O-])=O)=CC=2)C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11930
Product name: SR 9011
Purity: ≥98%
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 11930
Product name: SR 9011
Purity: ≥98%
Packaging: 5mg
Price: $384
Updated: 2024/03/01

TRC

Product number: S684260
Product name: SR9011
Packaging: 25mg
Price: $2180
Updated: 2021/12/16

AK Scientific

Product number: 4689DN
Product name: SR-9011
Packaging: 5mg
Price: $525
Updated: 2021/12/16

ApexBio Technology

Product number: B1768
Product name: SR9011
Packaging: 2mg
Price: $126
Updated: 2021/12/16

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SR9011 Chemical Properties,Usage,Production

Biochem/physiol Actions

SR9011 is a potent nuclear receptor REV-ERB agonist (EC50 of REV-ERBα- and REV-ERBβ-dependent repressor activity = 790 and 560 nM, respectively, by cell-based reporter assay) that stimulates REV-ERB-dependent target genes suppression both in cultures in vitro and in mice in vivo (100 mg/kg i.p., b.i.d.) without activity toward a panel of 46 other nuclear receptors. SR9011 is shown to modulate circadian behavior by suppressing the transcription factors BMAL1 (brain and muscle ARNT-like protein 1) and CLOCK (circadian locomotor output cycles kaput) as well as induce energy expenditure and weight loss by regulating genes involved in lipid and glucose metabolism in mice in vivo with good bioavailabiilty (plasma conc. = 0.53 and 15.3 μM 2 hr post 10 or 100 mg/kg i.p. dosage; brain conc. = 0.24 μM 2 hr post 10 mg/kg i.p.), while its structure analog GSK4112 shows no plasma exposure.

Uses

SR 9011 is a synthetic REV-ERBα/β agonist with activity in vivo. It is a lead compound for a new class of cancer drugs associated with the body’s circadian clock.

Application

SR9011 has been used as a nuclear receptor subfamily 1 group D member 1 (NR1D1) receptor agonist:
to study its effects on microglial immune-metabolism
to study its effects on insulin secretion from human type 2 diabetes islet cells
to study its effects on thyroid-stimulating hormone β (TSHβ) gene expression

SR9011 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR9011 Suppliers

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View Lastest Price from SR9011 manufacturers

Dorne Chemical Technology co. LTD

Product: SR9011 1379686-29-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

Wuhan Cell Pharmaceutical Co., Ltd

Product: SR9011 1379686-29-9
Price: US $9.90-17337.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2023-03-30

hebei hongtan Biotechnology Co., Ltd

Product: SR9011 1379686-29-9
Price: US $90.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 1000
Release date: 2024-03-21

1379686-29-9, SR9011Related Search:

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SR9011 Sarms powder

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1379686-29-9

C23H31ClN4O3S

1379686-29-9

SARMS