SR-9243

Product Name: SR-9243
CAS No.: 1613028-81-1
Chemical Name: SR-9243
Synonyms: SR-9243;CS-1645;SR 9243;SR9243;SR-9243;N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-;N-(3-Bromophenethyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide;N-(3-bromophenethyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide;N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]benzenesulfonamide;Benzenesulfonamide, N-[2-(3-bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-
CBNumber: CB23035285
Molecular Formula: C31H32BrNO4S2
Formula Weight: 626.62
MOL File: 1613028-81-1.mol

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SR-9243 Property

Melting point:: 154-155°C
Boiling point:: 786.3±70.0 °C(Predicted)
Density: 1.347±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (greater than 25 mg/ml)
pka: -6.90±0.70(Predicted)
form: solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

HS Code: 29350090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18420
Product name: SR9243
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18420
Product name: SR9243
Purity: ≥95%
Packaging: 5mg
Price: $70
Updated: 2024/03/01

Cayman Chemical

Product number: 18420
Product name: SR9243
Purity: ≥95%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 18420
Product name: SR9243
Purity: ≥95%
Packaging: 50mg
Price: $351
Updated: 2024/03/01

Tocris

Product number: 6138
Product name: SR9243
Purity: ≥98%(HPLC)
Packaging: 10
Price: $159
Updated: 2021/12/16

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SR-9243 Chemical Properties,Usage,Production

Description

The liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors. They modulate lipid, cholesterol, and carbohydrate metabolism and homeostasis. SR9243 is a cell-permeable LXR inverse agonist that induces LXR-corepressor interaction at nanomolar concentrations. It reduces cancer cell viability (IC₅₀ values range from 15 to 104 nM) without cytotoxicity against non-malignant cells. SR9243 disrupts the Warburg effect in cancer cells, suppressing the expression of glycolytic and lipogenic genes and reducing glycolytic metabolites and lipid production. It is effective in vivo, blocking glycolytic and lipogenic gene expression and inducing apoptosis in colon cancer xenografts without inducing weight loss in mice.

Uses

SR9243 is used in new compounds targeting warburg effcts, killing cancer cells and inhibiting lipid production.

Definition

ChEBI: SR9243 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of mesitylene-2-sulphonic acid with the amino group of 2-(m-bromophenyl)ethylamine in which the nitrogen is substituted by a 4-[m-(methylsulfonyl)phenyl]benzyl group. It has a role as an antineoplastic agent, an apoptosis inducer and a liver X receptor inverse agonist. It is a sulfonamide, a sulfone and a member of bromobenzenes.

storage

Store at +4°C

References

1) Flaveny?et al. (2015),?Broad anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis; Cancer Cell,?28?42

SR-9243 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR-9243 Suppliers

China 86 United Kingdom 1 United States 13 Global 100

Shanghai Boyle Chemical Co., Ltd.

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Chembest Research Laboratories Limited

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Dalian Meilun Biotech Co., Ltd.

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T&W GROUP

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Haoyuan Chemexpress Co., Ltd.

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MedChemexpress LLC

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TargetMol Chemicals Inc.

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Wuhan HengHeDa Pharm Co., Ltd.

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AdooQ Bioscience CHINA

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Shanghai JiYi Biotechnology Co. Ltd.

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1613028-81-1, SR-9243Related Search:

4-Quinolinecarboxamide, N-[3-[[[2-[4-(aminosulfonyl)phenyl]ethyl]amino]carbonyl]phenyl]-1,2-dihydro-2-oxo- NA SR-717 SRT3025 SR8278 SR19881 SRPK inhibitor SR 1078 N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide SRI 31215 SR 0987 SR27897 SR17018 SR 12813 N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide SR9009 SR9011 2-Chloro-N-(6-methoxy-4-quinolinyl)-5-nitrobenzamide

SR 9243;SR9243;SR-9243

CS-1645

SR-9243

N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]benzenesulfonamide

N-(3-bromophenethyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide

Benzenesulfonamide, N-[2-(3-bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-

N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-

N-(3-Bromophenethyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide

1613028-81-1

C31H32BrNO4S2

Inhibitors

API