SRPK inhibitor
- Product Name
- SRPK inhibitor
- CAS No.
- 218156-96-8
- Chemical Name
- SRPK inhibitor
- Synonyms
- CS-910;SRPIN340;SRPIN 340;SRPIN-340;SRPK inhibitor;SRPIN340, >=98%;SRPIN340 >=98% (HPLC);SRPIN340, 10 mM in DMSO;SRPK Inhibitor(SRPIN340);SRPIN340 (SRPK inhibitor)
- CBNumber
- CB22668305
- Molecular Formula
- C18H18F3N3O
- Formula Weight
- 349.35
- MOL File
- 218156-96-8.mol
SRPK inhibitor Property
- Boiling point:
- 395.9±42.0 °C(Predicted)
- Density
- 1.306±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- pka
- 11.09±0.70(Predicted)
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1088
- Product name
- SRPIN340
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $121
- Updated
- 2025/07/31
- Product number
- SML1088
- Product name
- SRPIN340
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $489
- Updated
- 2025/07/31
- Product number
- 5.04293
- Product name
- SRPK Inhibitor, SRPIN340 - CAS 281856-96-8 - Calbiochem
- Packaging
- 10mg
- Price
- $204
- Updated
- 2023/01/07
- Product number
- 16284
- Product name
- SRPIN340
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 16284
- Product name
- SRPIN340
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
SRPK inhibitor Chemical Properties,Usage,Production
Description
Serine/arginine-rich protein kinase 1 (SRPK1) targets proteins that contain multiple serine/arginine (SR) dipeptides, including SR-
Uses
SRPIN340 is a SRPK1 kinase inhibitor, which shows potential novel targeted therapeutic strategy in prostate cancer.
Synthesis
1496-40-8
39178-35-3
218156-96-8
The general procedure for the synthesis of N-(2-(1-piperidinyl)-5-(trifluoromethyl)phenyl)isonicotinamide from 2-piperidin-1-yl-5-(trifluoromethyl)aniline and isocyanidinium chloride is as follows: isonicotinic acid chloride hydrochloride (6.48 g, 36.4 mmol, commercially available) and triethylamine (5.57 ml, 54.6 mmol) are sequentially added at 0°C to the 2-(1-piperidinyl)-5-(trifluoromethyl)aniline (4.45 g, 18.2 mmol, prepared as described in Reference Examples 1-2B) to a solution of methylene chloride (10 ml). The reaction mixture was stirred for 30 minutes. Subsequently, water was added to the mixture and extracted three times with ethyl acetate. The organic layers were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (200 g silica gel, eluent ratio hexane/ethyl acetate = 1/1) and recrystallized. The final N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide (SRPIN-1, GIF-0340) (5.49 g, 86.3% yield) was obtained as a colorless solid.
References
[1] TAKESHI FUKUHARA. Utilization of host SR protein kinases and RNA-splicing machinery during viral replication.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006: 11329-11333. DOI:10.1073/pnas.0604616103
[2] MELISSA V R GAMMONS. SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity.[J]. ACS Applied Materials & Interfaces, 2013: 5797-5806. DOI:10.1167/iovs.13-11634
[3] M V GAMMONS. Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma[J]. British Journal of Cancer, 2014, 111 3: 477-485. DOI:10.1038/bjc.2014.342
SRPK inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SRPK inhibitor manufacturers
- Product
- SRPK inhibitor 218156-96-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20kg
- Release date
- 2019-09-05