SR-18292

Product Name: SR-18292
CAS No.: 2095432-55-4
Chemical Name: SR-18292
Synonyms: SR-18292;SR-18292 ，S8528;SR 18292;SR18292;SR-18292, 10 mM in DMSO;SR-18292; SR 18292; SR18292;1-((1H-Indol-4-yl)oxy)-3-(tert-butyl(4-methylbenzyl)amino)propan-2-ol;PPARγ coactivator-1α,PGC-1α,Autophagy,SR18292,SR-18292,Inhibitor,inhibit;2-Propanol, 1-[(1,1-dimethylethyl)[(4-methylphenyl)methyl]amino]-3-(1H-indol-4-yloxy)-
CBNumber: CB43344893
Molecular Formula: C23H30N2O2
Formula Weight: 366.5
MOL File: 2095432-55-4.mol

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SR-18292 Property

Boiling point:: 553.6±50.0 °C(Predicted)
Density: 1.132±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml; Ethanol: 10 mg/ml
form: A crystalline solid
pka: 13.90±0.20(Predicted)
color: White to light brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2146
Product name: SR-18292 Maleate
Purity: ≥98%(HPLC)
Packaging: 5mg
Price: $194
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2146
Product name: SR-18292 Maleate
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $489
Updated: 2025/07/31

Cayman Chemical

Product number: 22084
Product name: SR 18292
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 22084
Product name: SR 18292
Purity: ≥95%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 22084
Product name: SR 18292
Purity: ≥95%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

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SR-18292 Chemical Properties,Usage,Production

Uses

SR 18292 is a novel selective inhibitor of PGC-1alpha Gluconeogenic Activity.

Biological Activity

SR-18292 is a potent and specific inhibitor of hepatic gluconeogenesis via increased acetylation of PGC-1α and suppression of gluconeogenic gene expression. SR-18292 reduces blood glucose and increases hepatic insulin sensitivity in mouse models of T2D.

in vivo

SR-18292 reduces fasting blood glucose, increases hepatic insulin sensitivity and improves glucose homeostasis in diabetic mice. The high fat diet (HFD) fed mice, a dietary model of obesity and T2D, are treated with SR-18292 (45mg/kg) via I.P. injection for 3 consecutive days and again on day 4 before measuring fasting blood glucose. Strikingly, mice that are treated with SR-18292 have significantly lower levels of fasting blood glucose concentrations compared to matched vehicle-treated control mice. The induction of gluconeogenic gene expression is a regulatory component of the response to fasting. Importantly, gluconeogenic gene expression, specifically that of Pck1, is inhibited in livers isolated from mice treated with SR-18292^[1].

SR-18292 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR-18292 Suppliers

China 80 India 1 United States 11 Global 92

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
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MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
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BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
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Twochem Co.Ltd

Tel: 021-021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 304
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
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ProdList: 71826
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Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
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View Lastest Price from SR-18292 manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: SR-18292 2095432-55-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-29

2095432-55-4, SR-18292Related Search:

SR19881 SRPK inhibitor SR 1078 2,2'-Bis(2-dichlorophenyl)-4,4'5,5'-tetraphenyl-1,2'-biimidazole

SR-18292

SR-18292; SR 18292; SR18292

SR 18292;SR18292

2-Propanol, 1-[(1,1-dimethylethyl)[(4-methylphenyl)methyl]amino]-3-(1H-indol-4-yloxy)-

1-((1H-Indol-4-yl)oxy)-3-(tert-butyl(4-methylbenzyl)amino)propan-2-ol

PPARγ coactivator-1α,PGC-1α,Autophagy,SR18292,SR-18292,Inhibitor,inhibit

SR-18292, 10 mM in DMSO

SR-18292 ，S8528

2095432-55-4