SR 1078
- Product Name
- SR 1078
- CAS No.
- 1246525-60-9
- Chemical Name
- SR 1078
- Synonyms
- SR 1078;SR 1078; SR-1078;SR 1078 USP/EP/BP;SR1078;SR 1078;SR-1078;SR1078,N-[4-(2,2,2-TRIFLUORO-1-HYDROXY-1-TRIFLUOROMETHYL-ETHYL)-PHENYL]-4-TRIFLU;N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-4-(trifluoromethyl)benzamide;N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]-4-(trifluoromethyl)benzamide;N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide;Benzamide, N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)-;SR1078,N-[4-(2,2,2-Trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenyl]-4-trifluoroMethyl-benzaMide
- CBNumber
- CB22628424
- Molecular Formula
- C17H10F9NO2
- Formula Weight
- 431.25
- MOL File
- 1246525-60-9.mol
SR 1078 Property
- Melting point:
- 169℃
- Boiling point:
- 362.9±42.0 °C(Predicted)
- Density
- 1.527±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO, Methanol (Slightly)
- form
- Solid
- pka
- 9.21±0.15(Predicted)
- color
- Off-White
N-Bromosuccinimide Price
- Product number
- 16503
- Product name
- SR 1078
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 16503
- Product name
- SR 1078
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 16503
- Product name
- SR 1078
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 4874
- Product name
- SR1078
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $171
- Updated
- 2021/12/16
- Product number
- 4874
- Product name
- SR1078
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $713
- Updated
- 2021/12/16
SR 1078 Chemical Properties,Usage,Production
Uses
SR 1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays.
Biological Activity
sr1078 is an agonist of retinoic acid receptor-related orphan receptor (ror) rorα and rorγ with ic50 values of both 1-3 μm [1].rorα and rorγ are two members of nuclear receptor superfamily, which possesses a highly conserved dna-binding and a ligand-binding domain. these two receptors are considered to play important roles in the regulation of metabolism and the function of immune system [1].sr1078 is a selective rorα and rorγ agonist, which activate rorα and rorγ directed transcription via inducing conformational changes [1].sr1078 selectively targets on rorα and rorγ as an agonist but not on lxr and fxr [1]. it was shown that sr1078 was able to stimulate ror activity and subsequent ror-directed mrna expression. when hepg2 cells were treated with sr1078 for 24h, the ror directed reporter gene fg21 mrna level was increased by 3-fold, while another reporter gene g6pase was increased by 2-fold [1].in mouse model, i.p. injection of 10 mg/kg sr1078 for 1 hr resulted in 3.6 μm plasma concentration., and after 8 hr the concentration still sustained at 800 nm. i.p. injection of 10 mg/kg sr1078 for 2 hr resulted in significantly increased level of mrna of reporter gene g6pase and fg21 [1].
storage
Store at +4°C
References
[1] wang y et al. , identification of a synthetic agonist for the orphan nuclear receptors rorα and rorγ, sr1078. acs chem biol., 2010, 5(11): 1029-1034.
SR 1078 Preparation Products And Raw materials
Raw materials
Preparation Products
SR 1078 Suppliers
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View Lastest Price from SR 1078 manufacturers
- Product
- SR 1078 1246525-60-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kgs
- Release date
- 2019-12-17