SR-4835

Product Name: SR-4835
CAS No.: 2387704-62-1
Chemical Name: SR-4835
Synonyms: SR-4853;SR-4835;SR-4835, 10 mM in DMSO;Cyclin dependent kinase,SR-4835,inhibit,CDK,Apoptosis,SR4835,Inhibitor,SR 4835;N-[(5,6-Dichloro-2-benzoimidazolyl)methyl]-9-(1-methyl-4-pyrazolyl)-2-morpholino-9H-purin-6-amine;N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(4-morpholinyl)-9H-purin-6-amine;9H-Purin-6-amine, N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(4-morpholinyl)-
CBNumber: CB85821187
Molecular Formula: C21H20Cl2N10O
Formula Weight: 499.36
MOL File: 2387704-62-1.mol

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SR-4835 Property

Boiling point:: 886.6±75.0 °C(Predicted)
Density: 1.72±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:5.0(Max Conc. mg/mL);10.0(Max Conc. mM)
form: Solid
pka: 9.13±0.30(Predicted)
color: Off-white to light brown
InChIKey: FSELUFUYNUNZKD-UHFFFAOYSA-N
SMILES: N1C2C(=NC(N3CCOCC3)=NC=2NCC2NC3=CC(Cl)=C(Cl)C=C3N=2)N(C2=CN(C)N=C2)C=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0106031
Product name: SR-4835
Purity: 98.46%
Packaging: 5mg
Price: $390
Updated: 2021/12/16

ChemScene

Product number: CS-0106031
Product name: SR-4835
Purity: 98.46%
Packaging: 10mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0106031
Product name: SR-4835
Purity: 98.46%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0106031
Product name: SR-4835
Purity: 98.46%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

DC Chemicals

Product number: DC27001
Product name: SR-4835
Purity: >98%
Packaging: 100mg
Price: $750
Updated: 2021/12/16

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SR-4835 Chemical Properties,Usage,Production

Uses

SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death[1].

IC 50

CDK12: 99 nM (IC₅₀); CDK12: 98 nM (Kd); CDK13: 4.9 nM (Kd)

References

[1] Quereda V, et al. Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer. Cancer Cell. 2019 Oct 8. pii: S1535-6108(19)30424-6. DOI:10.1016/j.ccell.2019.09.004

SR-4835 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR-4835 Suppliers

China 78 United States 3 Global 81

Jingmo (Xiamen) Biotechnology Co., Ltd

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2387704-62-1, SR-4835Related Search:

4-Quinolinecarboxamide, N-[3-[[[2-[4-(aminosulfonyl)phenyl]ethyl]amino]carbonyl]phenyl]-1,2-dihydro-2-oxo- NA SR-717 SRT3025 SR9009 SR19881 SRPK inhibitor SR 1078 N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide SRI 31215 SR 0987 SR27897 SR17018 SR-9243 SR 3029 SR 16832 SR8278 SR18662

SR-4835

SR-4853

9H-Purin-6-amine, N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(4-morpholinyl)-

Cyclin dependent kinase,SR-4835,inhibit,CDK,Apoptosis,SR4835,Inhibitor,SR 4835

N-[(5,6-Dichloro-2-benzoimidazolyl)methyl]-9-(1-methyl-4-pyrazolyl)-2-morpholino-9H-purin-6-amine

N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(4-morpholinyl)-9H-purin-6-amine

SR-4835, 10 mM in DMSO

2387704-62-1

C21H20Cl2N10O