SR 3029
- Product Name
- SR 3029
- CAS No.
- 1454585-06-8
- Chemical Name
- SR 3029
- Synonyms
- CS-2390;SR-3029;SR-3029, >98%;SR-3029 (SR 3029;SR-3029, 10 mM in DMSO;SR 3029,Inhibitor,SR-3029,Casein Kinase,inhibit;N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine;N-((6,7-Difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine;N-[(6,7-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-(4-morpholinyl)-9H-purin-6-amine;9H-Purin-6-amine, N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-(4-morpholinyl)-
- CBNumber
- CB03123142
- Molecular Formula
- C23H19F3N8O
- Formula Weight
- 480.45
- MOL File
- 1454585-06-8.mol
SR 3029 Property
- Boiling point:
- 818.7±75.0 °C(Predicted)
- Density
- 1.62±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml
- form
- A solid
- pka
- 8.76±0.30(Predicted)
- color
- White to pink
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 27048
- Product name
- SR 3029
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 27048
- Product name
- SR 3029
- Packaging
- 25mg
- Price
- $258
- Updated
- 2024/03/01
- Product number
- 27048
- Product name
- SR 3029
- Packaging
- 10mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 5767
- Product name
- SR3029
- Purity
- ≥98%(HPLC)
- Packaging
- 5
- Price
- $224
- Updated
- 2021/12/16
- Product number
- S684538
- Product name
- SR-3029
- Packaging
- 10mg
- Price
- $320
- Updated
- 2021/12/16
SR 3029 Chemical Properties,Usage,Production
Uses
SR-3029 is a potent and selective CK1δ and CK1ε inhibitor (IC50 values are 44 and 260 nM, respectively). Exhibits selectivity for CK1δ and CK1ε over a panel of other kinases. Inhibits proliferation of melanoma and breast cancer cell lines in vitro. Also inhibits growth of breast tumor xenografts in mice.
in vivo
SR-3029 (20 mg/kg daily i.p.) exibits anti-tumor effects in rthotopic MDA-MB-231, MDA-MB-468 (TNBC), SKBR3 and BT474 (HER2+) tumor xenografts with no overt toxicity in mice. SR-3029 (20 mg/kg daily i.p.) also effectively inhibits the growth of tumor in primary patient-derived xenograft (PDX) models. In addition, SR-3029 (20 mg/kg, i.p.) strongly reduces the expression of nuclear β-catenin in tumors of mice[2].
IC 50
CKIδ: 44 nM (IC50); CDK6/cyclin D3: 427 nM (IC50); CDK6/cyclin D1: 428 nM (IC50); CDK4/cyclin D3: 368 nM (IC50); CDK4/cyclin D1: 576 nM (IC50); FLT3: 3000 nM (IC50)
storage
Store at +4°C
References
[1]. Bibian M, et al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80.
[2]. Rosenberg LH, et al. Therapeutic targeting of casein kinase 1δ in breast cancer. Sci Transl Med. 2015 Dec 16;7(318):318ra202.
[3]. ELISABETH PEER. Casein Kinase 1D Encodes a Novel Drug Target in Hedgehog-GLI-Driven Cancers and Tumor-Initiating Cells Resistant to SMO Inhibition.[J]. Cancers, 2021. DOI:10.3390/cancers13164227.
SR 3029 Preparation Products And Raw materials
Raw materials
Preparation Products
SR 3029 Suppliers
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