ChemicalBook > CAS DataBase List > SR 3029

SR 3029

Product Name: SR 3029
CAS No.: 1454585-06-8
Chemical Name: SR 3029
Synonyms: CS-2390;SR-3029;SR-3029, >98%;SR-3029 (SR 3029;SR-3029, 10 mM in DMSO;SR 3029,Inhibitor,SR-3029,Casein Kinase,inhibit;N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine;N-((6,7-Difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine;N-[(6,7-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-(4-morpholinyl)-9H-purin-6-amine;9H-Purin-6-amine, N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-(4-morpholinyl)-
CBNumber: CB03123142
Molecular Formula: C23H19F3N8O
Formula Weight: 480.45
MOL File: 1454585-06-8.mol

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SR 3029 Property

Boiling point:: 818.7±75.0 °C(Predicted)
Density: 1.62±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml
form: A solid
pka: 8.76±0.30(Predicted)
color: White to pink

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27048
Product name: SR 3029
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 27048
Product name: SR 3029
Packaging: 25mg
Price: $258
Updated: 2024/03/01

Cayman Chemical

Product number: 27048
Product name: SR 3029
Packaging: 10mg
Price: $161
Updated: 2024/03/01

Tocris

Product number: 5767
Product name: SR3029
Purity: ≥98%(HPLC)
Packaging: 5
Price: $224
Updated: 2021/12/16

TRC

Product number: S684538
Product name: SR-3029
Packaging: 5mg
Price: $200
Updated: 2021/12/16

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SR 3029 Chemical Properties,Usage,Production

Uses

SR-3029 is a potent and selective CK1δ and CK1ε inhibitor (IC50 values are 44 and 260 nM, respectively). Exhibits selectivity for CK1δ and CK1ε over a panel of other kinases. Inhibits proliferation of melanoma and breast cancer cell lines in vitro. Also inhibits growth of breast tumor xenografts in mice.

in vivo

SR-3029 (20 mg/kg daily i.p.) exibits anti-tumor effects in rthotopic MDA-MB-231, MDA-MB-468 (TNBC), SKBR3 and BT474 (HER2+) tumor xenografts with no overt toxicity in mice. SR-3029 (20 mg/kg daily i.p.) also effectively inhibits the growth of tumor in primary patient-derived xenograft (PDX) models. In addition, SR-3029 (20 mg/kg, i.p.) strongly reduces the expression of nuclear β-catenin in tumors of mice^[2].

IC 50

CKIδ: 44 nM (IC₅₀); CDK6/cyclin D3: 427 nM (IC₅₀); CDK6/cyclin D1: 428 nM (IC₅₀); CDK4/cyclin D3: 368 nM (IC₅₀); CDK4/cyclin D1: 576 nM (IC₅₀); FLT3: 3000 nM (IC₅₀)

storage

Store at +4°C

References

[1]. Bibian M, et al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80.
[2]. Rosenberg LH, et al. Therapeutic targeting of casein kinase 1δ in breast cancer. Sci Transl Med. 2015 Dec 16;7(318):318ra202.
[3]. ELISABETH PEER. Casein Kinase 1D Encodes a Novel Drug Target in Hedgehog-GLI-Driven Cancers and Tumor-Initiating Cells Resistant to SMO Inhibition.[J]. Cancers, 2021. DOI:10.3390/cancers13164227.

SR 3029 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR 3029 Suppliers

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1454585-06-8, SR 3029Related Search:

N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide SR9009 4-Quinolinecarboxamide, N-[3-[[[2-[4-(aminosulfonyl)phenyl]ethyl]amino]carbonyl]phenyl]-1,2-dihydro-2-oxo- NA SR-717 SRT3025 SR19881 SRPK inhibitor SR 1078 N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide SRI 31215 SR 0987 SR27897 SR17018 SR 12813 SR8278 SR 16832 SR-9243

N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine

SR-3029

N-[(6,7-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-(4-morpholinyl)-9H-purin-6-amine

N-((6,7-Difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine

CS-2390

SR-3029 (SR 3029

SR-3029, >98%

9H-Purin-6-amine, N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-(4-morpholinyl)-

SR 3029,Inhibitor,SR-3029,Casein Kinase,inhibit

SR-3029, 10 mM in DMSO

1454585-06-8

C23H19F3N8O