SR 1078

ChemicalBook > CAS DataBase List > SR 1078

Product Name: SR 1078
CAS No.: 1246525-60-9
Chemical Name: SR 1078
Synonyms: SR 1078;SR 1078; SR-1078;SR 1078 USP/EP/BP;SR1078;SR 1078;SR-1078;SR1078,N-[4-(2,2,2-TRIFLUORO-1-HYDROXY-1-TRIFLUOROMETHYL-ETHYL)-PHENYL]-4-TRIFLU;N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-4-(trifluoromethyl)benzamide;N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]-4-(trifluoromethyl)benzamide;N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide;Benzamide, N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)-;SR1078,N-[4-(2,2,2-Trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenyl]-4-trifluoroMethyl-benzaMide
CBNumber: CB22628424
Molecular Formula: C17H10F9NO2
Formula Weight: 431.25
MOL File: 1246525-60-9.mol

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SR 1078 Property

Melting point:: 169℃
Boiling point:: 362.9±42.0 °C(Predicted)
Density: 1.527±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO, Methanol (Slightly)
form: Solid
pka: 9.21±0.15(Predicted)
color: Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16503
Product name: SR 1078
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16503
Product name: SR 1078
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 16503
Product name: SR 1078
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Tocris

Product number: 4874
Product name: SR1078
Purity: ≥98%(HPLC)
Packaging: 10
Price: $171
Updated: 2021/12/16

Tocris

Product number: 4874
Product name: SR1078
Purity: ≥98%(HPLC)
Packaging: 50
Price: $713
Updated: 2021/12/16

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SR 1078 Chemical Properties,Usage,Production

Uses

SR 1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays.

Biological Activity

sr1078 is an agonist of retinoic acid receptor-related orphan receptor (ror) rorα and rorγ with ic50 values of both 1-3 μm [1].rorα and rorγ are two members of nuclear receptor superfamily, which possesses a highly conserved dna-binding and a ligand-binding domain. these two receptors are considered to play important roles in the regulation of metabolism and the function of immune system [1].sr1078 is a selective rorα and rorγ agonist, which activate rorα and rorγ directed transcription via inducing conformational changes [1].sr1078 selectively targets on rorα and rorγ as an agonist but not on lxr and fxr [1]. it was shown that sr1078 was able to stimulate ror activity and subsequent ror-directed mrna expression. when hepg2 cells were treated with sr1078 for 24h, the ror directed reporter gene fg21 mrna level was increased by 3-fold, while another reporter gene g6pase was increased by 2-fold [1].in mouse model, i.p. injection of 10 mg/kg sr1078 for 1 hr resulted in 3.6 μm plasma concentration., and after 8 hr the concentration still sustained at 800 nm. i.p. injection of 10 mg/kg sr1078 for 2 hr resulted in significantly increased level of mrna of reporter gene g6pase and fg21 [1].

storage

Store at +4°C

References

[1] wang y et al. , identification of a synthetic agonist for the orphan nuclear receptors rorα and rorγ, sr1078. acs chem biol., 2010, 5(11): 1029-1034.

SR 1078 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SR 1078 manufacturers

Career Henan Chemical Co

Product: SR 1078 1246525-60-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kgs
Release date: 2019-12-17

1246525-60-9, SR 1078Related Search:

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N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide

SR 1078

SR1078,N-[4-(2,2,2-Trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenyl]-4-trifluoroMethyl-benzaMide

N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide SR1078

SR1078;SR 1078;SR-1078

N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]-4-(trifluoromethyl)benzamide

SR1078,N-[4-(2,2,2-TRIFLUORO-1-HYDROXY-1-TRIFLUOROMETHYL-ETHYL)-PHENYL]-4-TRIFLU

SR 1078; SR-1078

Benzamide, N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)-

SR 1078 USP/EP/BP

N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-4-(trifluoromethyl)benzamide

1246525-60-9

C17H10F9NO2