ChemicalBook > CAS DataBase List > SRPK inhibitor

SRPK inhibitor

Product Name: SRPK inhibitor
CAS No.: 218156-96-8
Chemical Name: SRPK inhibitor
Synonyms: CS-910;SRPIN340;SRPIN 340;SRPIN-340;SRPK inhibitor;SRPIN340, >=98%;SRPIN340 >=98% (HPLC);SRPIN340, 10 mM in DMSO;SRPK Inhibitor(SRPIN340);SRPIN340 (SRPK inhibitor)
CBNumber: CB22668305
Molecular Formula: C18H18F3N3O
Formula Weight: 349.35
MOL File: 218156-96-8.mol

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SRPK inhibitor Property

Boiling point:: 395.9±42.0 °C(Predicted)
Density: 1.306±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
pka: 11.09±0.70(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1088
Product name: SRPIN340
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $121
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1088
Product name: SRPIN340
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $489
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.04293
Product name: SRPK Inhibitor, SRPIN340 - CAS 281856-96-8 - Calbiochem
Packaging: 10mg
Price: $204
Updated: 2023/01/07

Cayman Chemical

Product number: 16284
Product name: SRPIN340
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16284
Product name: SRPIN340
Purity: ≥95%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

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SRPK inhibitor Chemical Properties,Usage,Production

Description

Serine/arginine-rich protein kinase 1 (SRPK1) targets proteins that contain multiple serine/arginine (SR) dipeptides, including SR-rich splicing factor 1, SRSF1. SRPIN340 is an isonicotinamide compound that inhibits SRPK1 (K_i = 0.89 μM). It is about 10-fold less effective against SRPK2 and does not inhibit the related SRPKs, Clk1 and Clk4. SRPIN340 suppresses the propagation of Sindbis virus in Vero cells and the replication of hepatitis C virus in Huh7/Rep-Feo-2a cells. By blocking SRPK1-mediated phosphorylation of SRSF1, SRPIN340 modulates alternative splicing of VEGF, reducing neovascularization both in cells and in animals.

Uses

SRPIN340 is a SRPK1 kinase inhibitor, which shows potential novel targeted therapeutic strategy in prostate cancer.

Synthesis

1496-40-8

39178-35-3

218156-96-8

The general procedure for the synthesis of N-(2-(1-piperidinyl)-5-(trifluoromethyl)phenyl)isonicotinamide from 2-piperidin-1-yl-5-(trifluoromethyl)aniline and isocyanidinium chloride is as follows: isonicotinic acid chloride hydrochloride (6.48 g, 36.4 mmol, commercially available) and triethylamine (5.57 ml, 54.6 mmol) are sequentially added at 0°C to the 2-(1-piperidinyl)-5-(trifluoromethyl)aniline (4.45 g, 18.2 mmol, prepared as described in Reference Examples 1-2B) to a solution of methylene chloride (10 ml). The reaction mixture was stirred for 30 minutes. Subsequently, water was added to the mixture and extracted three times with ethyl acetate. The organic layers were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (200 g silica gel, eluent ratio hexane/ethyl acetate = 1/1) and recrystallized. The final N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide (SRPIN-1, GIF-0340) (5.49 g, 86.3% yield) was obtained as a colorless solid.

References

[1] TAKESHI FUKUHARA. Utilization of host SR protein kinases and RNA-splicing machinery during viral replication.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006: 11329-11333. DOI:10.1073/pnas.0604616103
[2] MELISSA V R GAMMONS. SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity.[J]. ACS Applied Materials & Interfaces, 2013: 5797-5806. DOI:10.1167/iovs.13-11634
[3] M V GAMMONS. Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma[J]. British Journal of Cancer, 2014, 111 3: 477-485. DOI:10.1038/bjc.2014.342

SRPK inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SRPK inhibitor manufacturers

Career Henan Chemical Co

Product: SRPK inhibitor 218156-96-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

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4-Pyridinecarboxamide, N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-

N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide SRPIN 340

SRPK inhibitor N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide

SRPIN 340

SRPIN340

SRPIN-340

SRPK inhibitor

N-(2-(piperidin-1-yl)-5-(trifluoroMethyl)phenyl)isonicotinaMide

N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide

SRPK Inhibitor(SRPIN340)

SRPIN340, >=98%

CS-910

SRPIN 340; SRPIN-340; SRPK INHIBITOR

N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide

SRPIN340 >=98% (HPLC)

SRPIN340 (SRPK inhibitor)

SRPIN340, 10 mM in DMSO

218156-96-8

Inhibitors