SR9011

Biochem/physiol Actions

Product Name: SR9011
CAS No.: 1379686-29-9
Chemical Name: SR9011
Synonyms: SR9001;SR9011;CS-2028;SR-90011;SR-9011;SR 9011;Stenabolic Sr9011;SR9011 Sarms powder;SR-9011;SR 9011;SR9011;White Powder SR9011Cas# 1379686-29-9 Raw Chemical Material;Trifunctional Methacrylate Monomer Sarm Steroids Powder Sr9011
CBNumber: CB12672925
Molecular Formula: C23H31ClN4O3S
Formula Weight: 479.04
MOL File: 1379686-29-9.mol

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SR9011 Property

Boiling point:: 642.8±50.0 °C(Predicted)
Density: 1.254±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 14.71±0.40(Predicted)
color: Dark Yellow to Very Dark Brown
InChI: InChI=1S/C23H31ClN4O3S/c1-2-3-4-12-25-23(29)27-13-11-19(16-27)15-26(14-18-5-7-20(24)8-6-18)17-21-9-10-22(32-21)28(30)31/h5-10,19H,2-4,11-17H2,1H3,(H,25,29)
InChIKey: PPUYOYQTTWJTIU-UHFFFAOYSA-N
SMILES: N1(C(NCCCCC)=O)CCC(CN(CC2=CC=C(Cl)C=C2)CC2SC([N+]([O-])=O)=CC=2)C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11930
Product name: SR 9011
Purity: ≥98%
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 11930
Product name: SR 9011
Purity: ≥98%
Packaging: 5mg
Price: $384
Updated: 2024/03/01

TRC

Product number: S684260
Product name: SR9011
Packaging: 25mg
Price: $2180
Updated: 2021/12/16

AK Scientific

Product number: 4689DN
Product name: SR-9011
Packaging: 5mg
Price: $525
Updated: 2021/12/16

ApexBio Technology

Product number: B1768
Product name: SR9011
Packaging: 2mg
Price: $126
Updated: 2021/12/16

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SR9011 Chemical Properties,Usage,Production

Biochem/physiol Actions

SR9011 is a potent nuclear receptor REV-ERB agonist (EC50 of REV-ERBα- and REV-ERBβ-dependent repressor activity = 790 and 560 nM, respectively, by cell-based reporter assay) that stimulates REV-ERB-dependent target genes suppression both in cultures in vitro and in mice in vivo (100 mg/kg i.p., b.i.d.) without activity toward a panel of 46 other nuclear receptors. SR9011 is shown to modulate circadian behavior by suppressing the transcription factors BMAL1 (brain and muscle ARNT-like protein 1) and CLOCK (circadian locomotor output cycles kaput) as well as induce energy expenditure and weight loss by regulating genes involved in lipid and glucose metabolism in mice in vivo with good bioavailabiilty (plasma conc. = 0.53 and 15.3 μM 2 hr post 10 or 100 mg/kg i.p. dosage; brain conc. = 0.24 μM 2 hr post 10 mg/kg i.p.), while its structure analog GSK4112 shows no plasma exposure.

Uses

SR 9011 is a synthetic REV-ERBα/β agonist with activity in vivo. It is a lead compound for a new class of cancer drugs associated with the body’s circadian clock.

Application

SR9011 has been used as a nuclear receptor subfamily 1 group D member 1 (NR1D1) receptor agonist:
to study its effects on microglial immune-metabolism
to study its effects on insulin secretion from human type 2 diabetes islet cells
to study its effects on thyroid-stimulating hormone β (TSHβ) gene expression

SR9011 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR9011 Suppliers

Australia 1 China 123 India 1 United States 11 Global 136

Yichang Chanod Biomedical Technology Co,LTD

Tel: 0717-6855399 15377615856
Email: sales@sndswyy.cn
Country: China
ProdList: 83
Advantage: 58

Hubei Zhaoke BIO-CHEMICAL Co., Ltd.

Tel: 027-87607080 13433334465
Email: 396587392@qq.com
Country: China
ProdList: 347
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

PURE SYNMR INGREDIENTS LIMITED

Tel: 021-26015538
Fax: 086-21-60457558
Email: sven_shi@puresynmr.com
Country: China
ProdList: 50
Advantage: 50

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Shanghai Linka Biotechnology Co., Ltd.

Tel: 15901858719
Fax: qq2126935757
Email: 2126935757@qq.com
Country: China
ProdList: 311
Advantage: 55

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3977
Advantage: 58

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View Lastest Price from SR9011 manufacturers

Wuhan Cell Pharmaceutical Co., Ltd

Product: SR9011 1379686-29-9
Price: US $9.90-17337.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2023-03-30

Shanghai Getian Industrial Co., LTD

Product: SR9011 1379686-29-9
Price: US $22.00/Box
Min. Order: 1Box
Purity: 99%
Supply Ability: 10000Box
Release date: 2024-04-28

Dorne Chemical Technology co. LTD

Product: SR9011 1379686-29-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

1379686-29-9, SR9011Related Search:

SR 12813 Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]- N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide SR9009 SR-9243 N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine

SR-9011;SR 9011;SR9011

CS-2028

SR9011

SR9001

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-N-pentyl-1-pyrrolidinecarboxamide

Stenabolic Sr9011

White Powder SR9011Cas# 1379686-29-9 Raw Chemical Material

SR-9011;SR 9011

SR-90011

1-Pyrrolidinecarboxamide, 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-N-pentyl-

Trifunctional Methacrylate Monomer Sarm Steroids Powder Sr9011

3-[[(4-Chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]-N-pentylpyrrolidine-1-carboxamide

3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide

SR9011 Sarms powder

3-({(4-Chlorobenzyl)[(5-nitro-2-thienyl)methyl]amino}methyl)-N-pentyl-1-pyrrolidinecarboxamide

1379686-29-9

C23H31ClN4O3S

1379686-29-9

SARMS