ChemicalBook > CAS DataBase List > SR-9243

SR-9243

Product Name: SR-9243
CAS No.: 1613028-81-1
Chemical Name: SR-9243
Synonyms: SR-9243;CS-1645;SR9243, 10 mM in DMSO;SR 9243;SR9243;SR-9243;N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-;N-(3-bromophenethyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide;N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]benzenesulfonamide;N-[2-(3-bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3’-(methylsulfonyl)[1,1’-biphenyl]-4-yl]methyl]-benzenesulfonamide;Benzenesulfonamide, N-[2-(3-bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-
CBNumber: CB23035285
Molecular Formula: C31H32BrNO4S2
Formula Weight: 626.62
MOL File: 1613028-81-1.mol

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SR-9243 Property

Melting point:: 154-155°C
Boiling point:: 786.3±70.0 °C(Predicted)
Density: 1.347±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (greater than 25 mg/ml)
pka: -6.90±0.70(Predicted)
form: solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

HS Code: 29350090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1517
Product name: SR9243
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $111
Updated: 2025/07/31

Cayman Chemical

Product number: 18420
Product name: SR9243
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18420
Product name: SR9243
Purity: ≥95%
Packaging: 5mg
Price: $70
Updated: 2024/03/01

Cayman Chemical

Product number: 18420
Product name: SR9243
Purity: ≥95%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 18420
Product name: SR9243
Purity: ≥95%
Packaging: 50mg
Price: $351
Updated: 2024/03/01

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SR-9243 Chemical Properties,Usage,Production

Description

The liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors. They modulate lipid, cholesterol, and carbohydrate metabolism and homeostasis. SR9243 is a cell-permeable LXR inverse agonist that induces LXR-corepressor interaction at nanomolar concentrations. It reduces cancer cell viability (IC₅₀ values range from 15 to 104 nM) without cytotoxicity against non-malignant cells. SR9243 disrupts the Warburg effect in cancer cells, suppressing the expression of glycolytic and lipogenic genes and reducing glycolytic metabolites and lipid production. It is effective in vivo, blocking glycolytic and lipogenic gene expression and inducing apoptosis in colon cancer xenografts without inducing weight loss in mice.

Uses

SR9243 is used in new compounds targeting warburg effcts, killing cancer cells and inhibiting lipid production.

Definition

ChEBI: SR9243 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of mesitylene-2-sulphonic acid with the amino group of 2-(m-bromophenyl)ethylamine in which the nitrogen is substituted by a 4-[m-(methylsulfonyl)phenyl]benzyl group. It has a role as an antineoplastic agent, an apoptosis inducer and a liver X receptor inverse agonist. It is a sulfonamide, a sulfone and a member of bromobenzenes.

in vivo

SR9243 is able to profoundly inhibit tumor glycolysis, lipogenesis, and induce apoptotic cancer cell death without promoting weight loss in vivo. SR9243 inhibits tumor growth without profoundly repressing glycolytic gene expression, and inhibits tumor growth and lipogenesis without hepatotoxicity or inflammation in vivo^[1].

storage

Store at +4°C

References

[1] COLIN A FLAVENY. Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis.[J]. Cancer Cell, 2015, 28 1: 42-56. DOI:10.1016/j.ccell.2015.05.007

SR-9243 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR-9243 Suppliers

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1613028-81-1, SR-9243Related Search:

N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide SR9009 SR9011 4-Quinolinecarboxamide, N-[3-[[[2-[4-(aminosulfonyl)phenyl]ethyl]amino]carbonyl]phenyl]-1,2-dihydro-2-oxo- NA SR-717 SRT3025 SR19881 SRPK inhibitor SR 1078 N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide SRI 31215 SR 0987 SR27897 SR17018 SR 12813 SR8278 SR 16832

SR 9243;SR9243;SR-9243

CS-1645

SR-9243

N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]benzenesulfonamide

N-(3-bromophenethyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide

Benzenesulfonamide, N-[2-(3-bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-

N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-

N-[2-(3-bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3’-(methylsulfonyl)[1,1’-biphenyl]-4-yl]methyl]-benzenesulfonamide

SR9243, 10 mM in DMSO

1613028-81-1

C31H32BrNO4S2

Inhibitors

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