ChemicalBook > CAS DataBase List > tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate

tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate

Product Name: tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate
CAS No.: 159503-91-0
Chemical Name: tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate
Synonyms: 1-N-Boc-3,6-Dihydro-2H-4-bromopyridine;1-Boc-4-bromo-1,2,3,6-tetrahydropyridine;tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate;tert-butyl 4-bromo-3,6-dihydropyridine-1(2H)-carboxylate;tert-butyl 4-bromo-1,2,3,6-tetrahydropyridine-1-carboxylate;Tert-butyl 4-bromo-5,6-dihydropyridine-1(2H)-carboxylate?New;2-Methyl-2-propanyl 4-bromo-3,6-dihydro-1(2H)-pyridinecarboxylate;1(2H)-Pyridinecarboxylic acid, 4-bromo-3,6-dihydro-, 1,1-dimethylethyl ester
CBNumber: CB12682094
Molecular Formula: C10H16BrNO2
Formula Weight: 262.14
MOL File: 159503-91-0.mol

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tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate Property

Boiling point:: 299.6±40.0 °C(Predicted)
Density: 1.377±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -2.90±0.40(Predicted)
form: liquid
color: Light yellow to yellow

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B700688
Product name: tert-Butyl4-Bromo-5,6-dihydropyridine-1(2H)-carboxylate
Packaging: 500mg
Price: $130
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-9-9H
Product name: tert-Butyl 4-bromo-5,6-dihydropyridine-1(2H)-carboxylate
Packaging: 1g
Price: $168
Updated: 2021/12/16

AK Scientific

Product number: X3977
Product name: tert-Butyl4-bromo-5,6-dihydropyridine-1(2H)-carboxylate
Packaging: 5g
Price: $323
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-9-9H
Product name: tert-Butyl 4-bromo-5,6-dihydropyridine-1(2H)-carboxylate
Packaging: 5G
Price: $440
Updated: 2021/12/16

Ambeed

Product number: A135591
Product name: tert-Butyl4-bromo-5,6-dihydropyridine-1(2H)-carboxylate
Purity: 95%
Packaging: 250mg
Price: $24
Updated: 2021/12/16

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tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate Chemical Properties,Usage,Production

Synthesis

79099-07-3

159503-91-0

Step 1: In a dry reaction flask, N-tert-butoxycarbonyl-4-piperidone (19.9 g, 0.1 mol), triphenyl phosphite (34.1 g, 0.11 mol), and triethylamine (15.2 g, 0.15 mol) were dissolved in 160 mL of dichloromethane, and the temperature of the reaction system was controlled to be between -25°C and -20°C. Subsequently, a dichloromethane solution (30 mL) of bromide (17.6 g, 0.11 mol) was slowly added dropwise under stirring. After the dropwise addition, the reaction was gradually warmed up to room temperature with continued stirring. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the solvent was removed by reduced pressure distillation and the residue was treated with 300 mL of pre-cooled 95% ethanol, stirred and filtered to collect the solid. The filtrate was dried and extracted by adding 150 mL of toluene and 40 mL of water, the toluene layer was washed with saturated brine, and the organic phase was dried and concentrated to give the crude product. Purification by column chromatography afforded N-tert-butoxycarbonyl-1,2,5,6-tetrahydropyridine-4-bromide in 80% yield (calibrated by internal standard method).

References

[1] Patent: CN105566367, 2016, A. Location in patent: Paragraph 0019
[2] Patent: CN105566368, 2016, A. Location in patent: Paragraph 0019

tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate 159503-91-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-09

Career Henan Chemical Co

Product: tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate 159503-91-0
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 1000kg
Release date: 2018-12-25

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