tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate
- Product Name
- tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate
- CAS No.
- 159503-91-0
- Chemical Name
- tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate
- Synonyms
- 1-N-Boc-3,6-Dihydro-2H-4-bromopyridine;1-Boc-4-bromo-1,2,3,6-tetrahydropyridine;tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate;tert-butyl 4-bromo-3,6-dihydropyridine-1(2H)-carboxylate;tert-butyl 4-bromo-1,2,3,6-tetrahydropyridine-1-carboxylate;Tert-butyl 4-bromo-5,6-dihydropyridine-1(2H)-carboxylate?New;2-Methyl-2-propanyl 4-bromo-3,6-dihydro-1(2H)-pyridinecarboxylate;1(2H)-Pyridinecarboxylic acid, 4-bromo-3,6-dihydro-, 1,1-dimethylethyl ester
- CBNumber
- CB12682094
- Molecular Formula
- C10H16BrNO2
- Formula Weight
- 262.14
- MOL File
- 159503-91-0.mol
tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate Property
- Boiling point:
- 299.6±40.0 °C(Predicted)
- Density
- 1.377±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -2.90±0.40(Predicted)
- form
- liquid
- color
- Light yellow to yellow
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B700688
- Product name
- tert-Butyl4-Bromo-5,6-dihydropyridine-1(2H)-carboxylate
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 4H56-9-9H
- Product name
- tert-Butyl 4-bromo-5,6-dihydropyridine-1(2H)-carboxylate
- Packaging
- 1g
- Price
- $168
- Updated
- 2021/12/16
- Product number
- X3977
- Product name
- tert-Butyl4-bromo-5,6-dihydropyridine-1(2H)-carboxylate
- Packaging
- 5g
- Price
- $323
- Updated
- 2021/12/16
- Product number
- 4H56-9-9H
- Product name
- tert-Butyl 4-bromo-5,6-dihydropyridine-1(2H)-carboxylate
- Packaging
- 5G
- Price
- $440
- Updated
- 2021/12/16
- Product number
- A135591
- Product name
- tert-Butyl4-bromo-5,6-dihydropyridine-1(2H)-carboxylate
- Purity
- 95%
- Packaging
- 25g
- Price
- $461
- Updated
- 2021/12/16
tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate Chemical Properties,Usage,Production
Synthesis
79099-07-3
159503-91-0
Step 1: In a dry reaction flask, N-tert-butoxycarbonyl-4-piperidone (19.9 g, 0.1 mol), triphenyl phosphite (34.1 g, 0.11 mol), and triethylamine (15.2 g, 0.15 mol) were dissolved in 160 mL of dichloromethane, and the temperature of the reaction system was controlled to be between -25°C and -20°C. Subsequently, a dichloromethane solution (30 mL) of bromide (17.6 g, 0.11 mol) was slowly added dropwise under stirring. After the dropwise addition, the reaction was gradually warmed up to room temperature with continued stirring. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the solvent was removed by reduced pressure distillation and the residue was treated with 300 mL of pre-cooled 95% ethanol, stirred and filtered to collect the solid. The filtrate was dried and extracted by adding 150 mL of toluene and 40 mL of water, the toluene layer was washed with saturated brine, and the organic phase was dried and concentrated to give the crude product. Purification by column chromatography afforded N-tert-butoxycarbonyl-1,2,5,6-tetrahydropyridine-4-bromide in 80% yield (calibrated by internal standard method).
References
[1] Patent: CN105566367, 2016, A. Location in patent: Paragraph 0019
[2] Patent: CN105566368, 2016, A. Location in patent: Paragraph 0019
tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate Preparation Products And Raw materials
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View Lastest Price from tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate manufacturers
- Product
- tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate 159503-91-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-09
- Product
- tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate 159503-91-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 1000kg
- Release date
- 2018-12-25