4-(di(1H-indol-3-yl)Methyl)phenol

Product Name: 4-(di(1H-indol-3-yl)Methyl)phenol
CAS No.: 151358-47-3
Chemical Name: 4-(di(1H-indol-3-yl)Methyl)phenol
Synonyms: C-DIM8;DIM-C-pPhOH;DIM-C-pPhOH(CDIM8);4-(di(1H-indol-3-yl)Methyl)phenol;4-[bis(1H-indol-3-yl)methyl]phenol;Phenol, 4-(di-1H-indol-3-ylmethyl)-;1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane;1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane;inhibit,receptor,Inhibitor,β1-integrin,mTOR,cancer,DIMCpPhOH,signaling,nuclear,xenografts,Apoptosis,DIM C pPhOH,stress
CBNumber: CB12682261
Molecular Formula: C23H18N2O
Formula Weight: 338.4
MOL File: 151358-47-3.mol

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4-(di(1H-indol-3-yl)Methyl)phenol Property

Melting point:: 122-124 °C
Boiling point:: 610.2±50.0 °C(Predicted)
Density: 1.321±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in DMSO (35 mg/ml); ethanol (35 mg/ml)
form: solid
pka: 9.98±0.26(Predicted)
color: Pink
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 6377
Product name: DIM-C-pPhOH
Purity: ≥98%(HPLC)
Packaging: 5
Price: $95
Updated: 2021/12/16

Tocris

Product number: 6377
Product name: DIM-C-pPhOH
Purity: ≥98%(HPLC)
Packaging: 25
Price: $371
Updated: 2021/12/16

Matrix Scientific

Product number: 105340
Product name: 4-(Di(1H-indol-3-yl)methyl)phenol
Packaging: 2g
Price: $975
Updated: 2021/12/16

Chemenu

Product number: CM265482
Product name: 4-(Di(1H-indol-3-yl)methyl)phenol
Purity: 95%+
Packaging: 5g
Price: $1234
Updated: 2021/12/16

Alichem

Product number: 151358473
Product name: 4-(Di(1H-indol-3-yl)methyl)phenol
Packaging: 5g
Price: $1306.8
Updated: 2021/12/16

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4-(di(1H-indol-3-yl)Methyl)phenol Chemical Properties,Usage,Production

Description

C-DIM 8 (151358-47-3) is an antagonist of the orphan nuclear receptor Nur77 (NR4A1, TR3).1 Induces reactive oxygen species and ER stress in pancreatic cancer cells.2 C-DIM 8 mimics the effect of Nur77 knockdown in non-small-cell lung cancer A549 and H460 cells, inhibiting cell growth and inducing apoptosis which was accompanied by decreased expression of survivin and inhibition of mTORC1 signaling.3 Inhibits the expression of β1- and β3-integrin and blocks integrin-dependent breast cancer cell migration.4 Decreases expression of the histone methyltransferase G9A (EHMT2) in a variety of cancer cell lines.5

storage

Store at -20°C

References

Chintharlapalli et al. (2005), Activation of Nur77 by selected 1,1-Bis(3’-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways; J. Biol. Chem., 280 24903 Lee et al. (2014), The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells; Mol. Cancer Res., 12 527 Lee et al. (2012), The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53; Oncogene, 31 3265 Hedrick et al. (2016), NR4A1 Antagonists Inhibit ?1-Integrin-Dependent Breast Cancer Cell Migration; Mol. Cell. Biol., 36 1383 Shrestha et al. (2021), The Histone Methyltransferase Gene G9A Is Regulated by Nuclear Receptor 4A1 in Alveolar Rhabdomyosarcoma Cells; Mol. Cancer Ther. 20 612

4-(di(1H-indol-3-yl)Methyl)phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(di(1H-indol-3-yl)Methyl)phenol Suppliers

China 53 India 1 United Kingdom 1 United States 7 Global 62

Adamas Reagent, Ltd.

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ShangHai Biochempartner Co.,Ltd

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Shanghai Chaolan Chemical Technology Center

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Beijing Solarbio Science & Tecnology Co., Ltd.

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4-(di(1H-indol-3-yl)Methyl)phenol

DIM-C-pPhOH

4-[bis(1H-indol-3-yl)methyl]phenol

C-DIM8

1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane

DIM-C-pPhOH(CDIM8)

Phenol, 4-(di-1H-indol-3-ylmethyl)-

inhibit,receptor,Inhibitor,β1-integrin,mTOR,cancer,DIMCpPhOH,signaling,nuclear,xenografts,Apoptosis,DIM C pPhOH,stress

1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane

151358-47-3