N-(4-Mesitylthiazol-2-yl)benzaMide
- Product Name
- N-(4-Mesitylthiazol-2-yl)benzaMide
- CAS No.
- 1001753-24-7
- Chemical Name
- N-(4-Mesitylthiazol-2-yl)benzaMide
- Synonyms
- INH6;INH-6; INH6;N-(4-Mesitylthiazol-2-yl)benzaMide;Apoptosis,Inhibitor,INH 6,INH6,INH-6,inhibit;N-(4-Mesitylthiazol-2-yl)benzaMide USP/EP/BP;N-[4-(2,4,6-trimethylphenyl)thiazol-2-yl]benzamide;N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-benzamide;Benzamide, N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-
- CBNumber
- CB12707933
- Molecular Formula
- C19H18N2OS
- Formula Weight
- 322.42
- MOL File
- 1001753-24-7.mol
N-(4-Mesitylthiazol-2-yl)benzaMide Property
- Melting point:
- 192-193 °C
- Density
- 1.216±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- solubility
- ≥32.2 mg/mL in DMSO; insoluble in H2O; ≥3.55 mg/mL in EtOH with gentle warming and ultrasonic
- form
- Powder
- pka
- 7.07±0.70(Predicted)
- CAS DataBase Reference
- 1001753-24-7
N-Bromosuccinimide Price
- Product number
- 373271
- Product name
- Hec1/Nek2MitoticPathwayInhibitorII,INH6-CAS1001753-24-7-Calbiochem
- Purity
- TheHec1/Nek2MitoticPathwayInhibitorII,INH6,alsoreferencedunderCAS1001
- Packaging
- 10mg
- Price
- $167
- Updated
- 2023/06/20
- Product number
- 21772
- Product name
- INH6
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 21772
- Product name
- INH6
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $76
- Updated
- 2024/03/01
- Product number
- 21772
- Product name
- INH6
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 21772
- Product name
- INH6
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $249
- Updated
- 2024/03/01
N-(4-Mesitylthiazol-2-yl)benzaMide Chemical Properties,Usage,Production
Uses
INH6 is a Hec1 inhibitor that targets the Hec1/Nek2 pathway and causes chromosome mis-alignment as well as cell death.
Biological Activity
inh6 is a potent inhibitor of hec1/nek2 [1].hec1 is an oncogene that involved in spindle checkpoint signaling and is overexpressed in many human cancers. nek2 is a serine/threonine-protein kinase that phosphorylates hec1, which is critical for its mitotic function and cell survival [1].inh6 is a potent hec1/nek2 inhibitor. inh6 inhibited hec1/nek2 function through protein degradation that led to chromosome mis-segregation and cell death. in mda-mb468 and mda-mb231 human breast cancer cell lines, hela human cervical cancer line and k562 human erythromyeloblastoid leukemia cell line, inh6 exhibited significantly anti-proliferation activities with ic50 values of 2.1, 1.7, 2.4 and 2.5 μm, respectively. in hela cell extract, inh6-conjugated matrix selectively co-precipitated with cellular hec1, which suggested that inh6 bound to cellular hec1. in hela cells, inh6 (6.25 μm) reduced nek2 by 50% at 8-11 h. in addition, inh6 slightly reduced hec1 over time. also, inh6 increased mitotic population with multipolar spindle configurations. in hela cells expressing the chromosome marker protein h2b-gfp, inh6 increased chromosome misalignment. in hela cells, inh6 exhibited progressive morphological changes of dying cells and induced apoptosis by 20% [1].
target
Hec1/Nek2 complex
References
[1]. qiu xl, li g, wu g, et al. synthesis and biological evaluation of a series of novel inhibitor of nek2/hec1 analogues. j med chem, 2009, 52(6): 1757-1767.
N-(4-Mesitylthiazol-2-yl)benzaMide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-(4-Mesitylthiazol-2-yl)benzaMide manufacturers
- Product
- INH6 1001753-24-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-30