LDC000067

ChemicalBook > CAS DataBase List > LDC000067

Product Name: LDC000067
CAS No.: 1073485-20-7
Chemical Name: LDC000067
Synonyms: LDC067;CS-1535;LDC-067;LDC 067;LDC000067;LDC000067(LDC-067);LDC000067 USP/EP/BP;LDC067;LDC 000067;LDC-000067;LDC 067;LDC-067;(3-(6-(2-Methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanesulfonamide;3-[[6-(2-methoxyphenyl)-4-pyrimidinyl]amino]-benzenemethanesulfonamide
CBNumber: CB12716267
Molecular Formula: C18H18N4O3S
Formula Weight: 370.43
MOL File: 1073485-20-7.mol

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LDC000067 Property

Boiling point:: 604.1±65.0 °C(Predicted)
Density: 1.360±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: insoluble in H2O; insoluble in EtOH; ≥18.52 mg/mL in DMSO
form: Powder
pka: 10.27±0.60(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29419
Product name: LDC000067
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 29419
Product name: LDC000067
Packaging: 25mg
Price: $317
Updated: 2024/03/01

Cayman Chemical

Product number: 29419
Product name: LDC000067
Packaging: 10mg
Price: $143
Updated: 2024/03/01

Tocris

Product number: 6752
Product name: LDC000067
Purity: ≥98%(HPLC)
Packaging: 25
Price: $316
Updated: 2021/12/16

AK Scientific

Product number: 2509AH
Product name: (3-((6-(2-Methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane
Packaging: 10mg
Price: $177
Updated: 2021/12/16

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LDC000067 Chemical Properties,Usage,Production

Biological Activity

ldc000067 (ldc067) is a novel specific inhibitor of cdk9 with ic50 value of 44 ± 10 nm [1].cyclin-dependent kinase 9 (cdk9) is a cyclin-dependent kinase. cdk9 and cyclin t form the positive transcription elongation factor b (p-tefb) complex for rna polymerase ii and functions by phosphorylating the c-terminal domain of the largest subunit of rna polymerase ii [1].ldc000067 (ldc067) is a novel and highly specific cdk9 inhibitor. ldc000067 exhibited selectivity for cdk9 over other cdks in the range of 55-fold (vs. cdk2) to over 230-fold (vs. cdk6 and cdk7). ldc067 also inhibited transcription in a dose-dependent and atp-competitive manner. in whole cells, ldc000067 induced the tumor suppressor protein p53 activation and apoptosis. ldc000067 also selectively reduced short-lived mrnas, including those that encode regulators of apoptosis and proliferation such as myc and mcl1 [1].

in vitro

LDC000067 reduces Ser2-P in mESCs, induces p53 activation, and leads to apoptosis. In addition, LDC067 also dose-dependently inhibited the de novo RNA synthesis of P-TEFb-dependent cellular genes.

target

Target	Value
CDK9 (Cell-free assay)	44 nM
CDK2 (Cell-free assay)	2.441 μM

storage

Store at -20°C

References

[1]. albert tk, rigault c, eickhoff j, et al. characterization of molecular and cellular functions of the cyclin-dependent kinase cdk9 using a novel specific inhibitor. br j pharmacol, 2014, 171(1): 55-68.

LDC000067 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from LDC000067 manufacturers

Career Henan Chemical Co

Product: (3-(6-(2-Methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanesulfonamide 1073485-20-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

1073485-20-7, LDC000067Related Search:

Diphenhydramine Sulfadiazine p-Anisidine Pictilisib Ribociclib BS-181 HCl (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Abemaciclib mesylate (LY2835219) PHA 767491 HYDROCHLORIDE

LDC000067

LDC 067

LDC067

LDC-067

(3-(6-(2-Methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanesulfonamide

3-[[6-(2-methoxyphenyl)-4-pyrimidinyl]amino]-benzenemethanesulfonamide

LDC067;LDC 000067;LDC-000067;LDC 067;LDC-067

CS-1535

LDC000067(LDC-067)

Benzenemethanesulfonamide, 3-[[6-(2-methoxyphenyl)-4-pyrimidinyl]amino]-

LDC000067 USP/EP/BP

LDC000067,CDK,LDC-067,Apoptosis,Cyclin dependent kinase,LDC 000067,LDC-000067,inhibit,LDC 067,Inhibitor

1073485-20-7

Inhibitors

API