LDC000067
- Product Name
- LDC000067
- CAS No.
- 1073485-20-7
- Chemical Name
- LDC000067
- Synonyms
- LDC067;CS-1535;LDC-067;LDC 067;LDC000067;LDC000067(LDC-067);LDC000067 USP/EP/BP;LDC067;LDC 000067;LDC-000067;LDC 067;LDC-067;(3-(6-(2-Methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanesulfonamide;3-[[6-(2-methoxyphenyl)-4-pyrimidinyl]amino]-benzenemethanesulfonamide
- CBNumber
- CB12716267
- Molecular Formula
- C18H18N4O3S
- Formula Weight
- 370.43
- MOL File
- 1073485-20-7.mol
LDC000067 Property
- Boiling point:
- 604.1±65.0 °C(Predicted)
- Density
- 1.360±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥18.52 mg/mL in DMSO
- form
- Powder
- pka
- 10.27±0.60(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 29419
- Product name
- LDC000067
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 29419
- Product name
- LDC000067
- Packaging
- 25mg
- Price
- $317
- Updated
- 2024/03/01
- Product number
- 29419
- Product name
- LDC000067
- Packaging
- 10mg
- Price
- $143
- Updated
- 2024/03/01
- Product number
- 6752
- Product name
- LDC000067
- Purity
- ≥98%(HPLC)
- Packaging
- 25
- Price
- $316
- Updated
- 2021/12/16
- Product number
- 2509AH
- Product name
- (3-((6-(2-Methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane
- Packaging
- 10mg
- Price
- $177
- Updated
- 2021/12/16
LDC000067 Chemical Properties,Usage,Production
Biological Activity
ldc000067 (ldc067) is a novel specific inhibitor of cdk9 with ic50 value of 44 ± 10 nm [1].cyclin-dependent kinase 9 (cdk9) is a cyclin-dependent kinase. cdk9 and cyclin t form the positive transcription elongation factor b (p-tefb) complex for rna polymerase ii and functions by phosphorylating the c-terminal domain of the largest subunit of rna polymerase ii [1].ldc000067 (ldc067) is a novel and highly specific cdk9 inhibitor. ldc000067 exhibited selectivity for cdk9 over other cdks in the range of 55-fold (vs. cdk2) to over 230-fold (vs. cdk6 and cdk7). ldc067 also inhibited transcription in a dose-dependent and atp-competitive manner. in whole cells, ldc000067 induced the tumor suppressor protein p53 activation and apoptosis. ldc000067 also selectively reduced short-lived mrnas, including those that encode regulators of apoptosis and proliferation such as myc and mcl1 [1].
in vitro
LDC000067 reduces Ser2-P in mESCs, induces p53 activation, and leads to apoptosis. In addition, LDC067 also dose-dependently inhibited the de novo RNA synthesis of P-TEFb-dependent cellular genes.
target
| Target | Value |
| CDK9 (Cell-free assay) | 44 nM |
| CDK2 (Cell-free assay) | 2.441 μM |
storage
Store at -20°C
References
[1]. albert tk, rigault c, eickhoff j, et al. characterization of molecular and cellular functions of the cyclin-dependent kinase cdk9 using a novel specific inhibitor. br j pharmacol, 2014, 171(1): 55-68.
LDC000067 Preparation Products And Raw materials
Raw materials
Preparation Products
LDC000067 Suppliers
View Lastest Price from LDC000067 manufacturers
- Product
- (3-(6-(2-Methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanesulfonamide 1073485-20-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-01