ChemicalBook > CAS DataBase List > LB-100
LB-100
- Product Name
- LB-100
- CAS No.
- 1026680-07-8
- Chemical Name
- LB-100
- Synonyms
- LB-100;CS-1762;LB-100, >95%;LB-100, 1026680-07-8;3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID;3-(1-methylpiperazine-4-carbonyl)-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid;methyl 2,5-dimethyl-1-[(2-methylpropan-2-yl)oxycarbonylamino]pyrrole-3-carboxylate LB-100;LB-100 3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID
- CBNumber
- CB12725546
- Molecular Formula
- C13H20N2O4
- Formula Weight
- 268.3089
- MOL File
- 1026680-07-8.mol
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LB-100 Property
- Melting point:
- >214°C (dec.)
- storage temp.
- Amber Vial, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Very Slightly, Heated), Methanol (Very Slightly, Heated)
- form
- Solid
- color
- White
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N-Bromosuccinimide Price
ApexBio Technology
- Product number
- B4846
- Product name
- LB-100
- Packaging
- 25mg
- Price
- $335
- Updated
- 2021/12/16
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LB-100 Chemical Properties,Usage,Production
Uses
LB-100 is a small molecule inhibitor of protein phosphatase 2A with potent chemo- and radio-sensitizing potential in variety of cancer types including pancreatic cancer and colorectal cancer of human and animal model.
Biological Activity
lb-100 is an inhibitor of protein phosphatase 2a (pp2a) with anticancer activity, with ic50 of 0.85 μm and 3.87 μm in bxpc-3 and panc-1 cells, respectively[1].in bxpc-3, panc-1, and sw1990 cells, lb-100 treatment reduced pp2a activity by 30-50%. lb-100 increases the intracellular doxorubicin concentration (about 2.5 times that of the control group) and makes tumor cells more sensitive to the cytotoxicity of doxorubicin[1].in a panc-1 mouse xenograft model, lb-100 (2 mg / kg, intraperitoneal injection) improves the efficacy of the chemotherapy drug doxorubicin. lb-100 increases tumor microvessel density and blood flow velocity on the tumor surface, and decreases tumor volume[1].[1]. bai x, zhi x, zhang q, et al. inhibition of protein phosphatase 2a sensitizes pancreatic cancer to chemotherapy by increasing drug perfusion via hif-1α-vegf mediated angiogenesis. cancer lett, 2014, 355(2): 281-287.
LB-100 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from LB-100 manufacturers
Career Henan Chemical Co
- Product
- LB-100 1026680-07-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98-100%
- Supply Ability
- 1000kg
- Release date
- 2018-08-20
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