ChemicalBook > CAS DataBase List > 1-(3-Fluoro-pyridin-4-yl)-ethanol

1-(3-Fluoro-pyridin-4-yl)-ethanol

Product Name
1-(3-Fluoro-pyridin-4-yl)-ethanol
CAS No.
87674-15-5
Chemical Name
1-(3-Fluoro-pyridin-4-yl)-ethanol
Synonyms
1-(3-Fluoro-pyridin-4-yl)-ethanol;4-(1-hydroxyethyl)-3-fluoropyridine;3-fluoro-a-methyl-4-Pyridinemethanol;4-Pyridinemethanol, 3-fluoro-a-methyl-;4-Pyridinemethanol, 3-fluoro-α-methyl-;3-FLUORO-ALPHA-METHYL-4-PYRIDINEMETHANOL
CBNumber
CB12727601
Molecular Formula
C7H8FNO
Formula Weight
141.14
MOL File
87674-15-5.mol
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1-(3-Fluoro-pyridin-4-yl)-ethanol Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Appearance
Light brown to brown Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
F600180
Product name
1-(3-Fluoropyridin-4-yl)ethanol
Packaging
25mg
Price
$175
Updated
2021/12/16
TRC
Product number
F600180
Product name
1-(3-Fluoropyridin-4-yl)ethanol
Packaging
2.5mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
4128CU
Product name
1-(3-Fluoropyridin-4-yl)ethanol
Packaging
100mg
Price
$85
Updated
2021/12/16
Ambeed
Product number
A312744
Product name
1-(3-Fluoropyridin-4-yl)ethanol
Purity
95+%
Packaging
1g
Price
$109
Updated
2021/12/16
Chemenu
Product number
CM255505
Product name
1-(3-Fluoropyridin-4-yl)ethanol
Purity
95%
Packaging
1g
Price
$137
Updated
2021/12/16
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1-(3-Fluoro-pyridin-4-yl)-ethanol Chemical Properties,Usage,Production

Synthesis

372-47-4

75-07-0

87674-15-5

To a stirred solution of 3-fluoropyridine (14 g, 144.2 mmol) in anhydrous THF (150 mL), cooled to -78°C under argon protection, a n-heptane/THF/ethylbenzene solution (79.2 mL, 158.6 mmol) of lithium 2 N diisopropylammonium (LDA) was added slowly dropwise over a period of about 1 hour. After stirring for 2.5 hours, a solution of acetaldehyde (8.9 mL, 158.5 mmol) in 25 mL of anhydrous THF cooled to about 0°C was added slowly dropwise and the reaction mixture was continued to be stirred at -78°C for 1.5 hours. Subsequently, the reaction solution was slowly warmed to -30 °C and the reaction was quenched by the addition of a solution of ammonium chloride (150 g) in 700 mL of water. The mixture was extracted with ethyl acetate (3 x 400 mL) and the combined organic layers were washed with brine (4 x 200 mL) and dried over anhydrous sodium sulfate. After concentrating the organic phase, the residual oily material was crystallized with hexane (40 mL) to give 15.6 g (76% yield) of 1-(3-fluoropyridin-4-yl)ethanol.

References

[1] Patent: WO2005/13986, 2005, A1. Location in patent: Page/Page column 44
[2] Patent: US2007/142414, 2007, A1. Location in patent: Page/Page column 18-19
[3] Patent: WO2007/96334, 2007, A1. Location in patent: Page/Page column 31-32
[4] Tetrahedron, 1983, vol. 39, # 12, p. 2009 - 2021

1-(3-Fluoro-pyridin-4-yl)-ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3-Fluoro-pyridin-4-yl)-ethanol Suppliers

China 26 India 1 United States 1 Global 28
Cochemical Ltd.
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029-86115547 17791676824
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sales@cochemical.com
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China
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Shanghai JingRon Chemical Technology Co., Ltd.
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021-60546673 13701861782
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QQ:670259431
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China
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Shanghai QianYan Bio-technology Co., Ltd
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02781293128
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orders@biochemsafebuy.com
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China
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AAB-PHARMA LIMITED
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025-66800956 18800000000
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qq3325708371
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sales@njdmchem.com
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Aikon International Limited
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Henan Alfachem Co.,Ltd.
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3A Chemicals
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Shanghai Jizhi Biochemical Technology Co. Ltd.
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4009004166/18616739031 18616739031
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3007523370@qq.com
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China
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Suzhou Rovathin Foreign Trade Co.,Ltd
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0512-65816829 18662214788
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0512-65816829
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info@rovathin.com.cn
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China
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View Lastest Price from 1-(3-Fluoro-pyridin-4-yl)-ethanol manufacturers

Career Henan Chemical Co
Product
4-(1-hydroxyethyl)-3-fluoropyridine 87674-15-5
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-02-05

87674-15-5, 1-(3-Fluoro-pyridin-4-yl)-ethanolRelated Search:


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  • 1-(3-Fluoro-pyridin-4-yl)-ethanol
  • 3-fluoro-a-methyl-4-Pyridinemethanol
  • 3-FLUORO-ALPHA-METHYL-4-PYRIDINEMETHANOL
  • 4-Pyridinemethanol, 3-fluoro-α-methyl-
  • 4-Pyridinemethanol, 3-fluoro-a-methyl-
  • 87674-15-5