MONO-BENZYL MALONATE
- Product Name
- MONO-BENZYL MALONATE
- CAS No.
- 40204-26-0
- Chemical Name
- MONO-BENZYL MALONATE
- Synonyms
- MONO-BENZYL MALONATE;Mono-Benzyl Malonate 95%;Mono-benzyl malonate, 95%,;MALONIC ACID MONO-BENZYL ESTER;3-oxo-3-phenylmethoxypropanoate;3-(benzyloxy)-3-oxopropanoic acid;3-oxo-3-phenylmethoxypropanoic acid;Propanedioic acid, 1-(phenylmethyl) ester;Propanedioic acid, Mono(phenylMethyl) ester
- CBNumber
- CB1273234
- Molecular Formula
- C10H10O4
- Formula Weight
- 194.18
- MOL File
- 40204-26-0.mol
MONO-BENZYL MALONATE Property
- Melting point:
- 47-51 °C (lit.)
- Boiling point:
- 352.3±25.0 °C(Predicted)
- Density
- 1.0737 g/cm3
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 2.82±0.32(Predicted)
- form
- Powder or Crystalline Powder
- color
- White to off-white
- InChIKey
- CFLAHQSWDKNWPW-UHFFFAOYSA-N
Safety
- WGK Germany
- 3
- HS Code
- 2917399590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 460656
- Product name
- mono-Benzyl malonate
- Purity
- 95%
- Packaging
- 10g
- Price
- $20.8
- Updated
- 2025/07/31
- Product number
- 456515
- Product name
- Monobenzyl Malonate
- Packaging
- 1g
- Price
- $319
- Updated
- 2021/12/16
- Product number
- M524880
- Product name
- mono-Benzyl malonate
- Packaging
- 50g
- Price
- $575
- Updated
- 2021/12/16
- Product number
- Y9369
- Product name
- 2-((Benzyloxy)carbonyl)aceticacid
- Packaging
- 1g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- CRB0002079
- Product name
- MONO-BENZYL MALONATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $637.3
- Updated
- 2021/12/16
MONO-BENZYL MALONATE Chemical Properties,Usage,Production
Uses
Monobenzyl Malonate is a useful synthetic intermediate. It was used to synthesize constrained cyclic agonists of the cholecystokinin CCK-B receptor. It was also used to prepare aspartate transcarbamoylase inhibitors.
Definition
ChEBI: A dicarboxylic acid monoester obtained by the formal condensation of one of the carboxy groups of malonic acid with benzyl alcohol.
General Description
mono-Benzyl malonate can be synthesized by the reaction of Meldrum′s acid (2,2-dimethyl- 1,3-dioxane-4,6-dione) with benzyl alcohol.
Synthesis
2033-24-1
100-51-6
40204-26-0
Meldrum acid (2.00 g, 13.8 mmol) and anhydrous acetonitrile (40 mL) were added to a flame-dried 150 mL pressure tube under argon protection. Benzyl alcohol (1.44 mL, 13.8 mmol) was added to the resulting solution and the reaction tube was sealed. The reaction mixture was refluxed overnight. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure and the product was purified by column chromatography (eluent: 70/30 hexane/ethyl acetate) to afford the target product, monophenylmethyl malonate (1.28 g, 6.59 mmol), as a colorless oil in 48% yield.
References
[1] Helvetica Chimica Acta, 2002, vol. 85, # 1, p. 288 - 319
[2] Heterocycles, 1993, vol. 35, # 2, p. 1205 - 1235
[3] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 3, p. 1143 - 1148
[4] Journal of Organometallic Chemistry, 2001, vol. 619, # 1-2, p. 179 - 193
[5] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 21, p. 4933 - 4936
MONO-BENZYL MALONATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from MONO-BENZYL MALONATE manufacturers
- Product
- mono-benzyl malonate 40204-26-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-28
- Product
- MONO-BENZYL MALONATE 40204-26-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24