ChemicalBook > CAS DataBase List > (S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID

(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID

Product Name
(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID
CAS No.
16626-02-1
Chemical Name
(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID
Synonyms
L-Trp(5-F)-OH;H-L-Trp(5-F)-OH*H2O;L-5-FLUOROTRYPTOPHAN;5-FLUORO-L-TRYPTOPHAN;H-5-FLUORO-TRP-OH H2O;Tryptophan Impurity 54;5-fluoro-L-tryptophans;L-Tryptophan, 5-fluoro-;5-Fluoro-tryptophan monohydrate;L-5-fluorotryptophan monohydrate
CBNumber
CB1274150
Molecular Formula
C11H11FN2O2
Formula Weight
222.22
MOL File
16626-02-1.mol
More
Less

(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID Property

Melting point:
238-239 °C
Boiling point:
450.7±45.0 °C(Predicted)
Density 
1.442±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
2.21±0.10(Predicted)
BRN 
5052680
More
Less

Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
10
HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
47568
Product name
5-Fluoro-L-tryptophan
Purity
≥98.0% (HPLC)
Packaging
25mg
Price
$186
Updated
2024/03/01
Apolloscientific
Product number
PC530031
Product name
5-Fluoro-L-tryptophan
Purity
97%
Packaging
1g
Price
$600
Updated
2021/12/16
Activate Scientific
Product number
AS87334
Product name
5-Fluoro-L-tryptophan
Purity
95+% ee
Packaging
5G
Price
$1349
Updated
2021/12/16
AK Scientific
Product number
8456AA
Product name
(S)-2-Amino-3-(5-fluoro-1H-indol-3-yl)propanoicacid
Packaging
5g
Price
$2650
Updated
2021/12/16
Activate Scientific
Product number
AS87334
Product name
5-Fluoro-L-tryptophan
Purity
95+% ee
Packaging
1g
Price
$491
Updated
2021/12/16
More
Less

(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID Chemical Properties,Usage,Production

Uses

Exogenous 5-fluoro-Trp is incorporated into proteins in normal protein synthesis. Since 19F is a useful reporter group, this provides a method for studying enzyme mechanisms by NMR.

Biochem/physiol Actions

5-Fluoro-Trp is nonspecifically cytotoxic. It is believed this is due to malfunctioning enzymes that have had replacements of Trp residues by 5-fluoro-Trp. However, at least one case is known where 5-fluoro-Trp substitution leads to significantly greater catalytic activity.

Purification Methods

Recrystallise it from EtOH, aqueous EtOH or AcOH. Also purify it by passage through a Dowex AG1x2 (acetate form) column and recrystallise the L-enantiomer (from enzymic enrichment) from H2O/EtOH, m 158-163o(dec), [] D -8.3o (c 2.5, N NaOH). [Coy et al. Biochemistry 13 3550 1974, Beilstein 22/14 V 116.]

(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID Suppliers

China 63 Germany 1 India 1 Switzerland 3 United Kingdom 4 United States 8 Global 80
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Apin Chemicals Limited (UK)
Tel
--
Fax
--
Email
info@apinchemicals.com
Country
United Kingdom
ProdList
6184
Advantage
60
Fulcrum Scientific Ltd.
Tel
--
Fax
--
Country
United Kingdom
ProdList
6565
Advantage
38
Apin Chemicals Ltd.
Tel
--
Fax
--
Email
info@apinchemicals.com
Country
United Kingdom
ProdList
6807
Advantage
42

16626-02-1, (S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACIDRelated Search:

Azelaic acid 5-Hydroxymethylfurfural Isoimperatorin Phosphatidylserine Soapnut Extract (-)-Huperzine A L-ALPHA-PHOSPHATIDYLSERINES, BRAIN, BOVINE 4-Aminobutyric acid Astaxanthin (2S)-2-Amino-3-(6-fluoro-1H-indol-3-yl)propionic acid,(S)-2-AMINO-3-(6-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID (S)-2-AMINO-3-(4-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID 7-CHLORO-L-TRYPTOPHAN (S)-2-AMINO-3-(4-CHLORO-1H-INDOL-3-YL)-PROPIONIC ACID (S)-2-AMINO-3-(5-CHLORO-1H-INDOL-3-YL)-PROPIONIC ACID H-TRP-GLY-OH (2S)-2-amino-3-(5-bromo-1H-indol-3-yl)propanoic acid 6-broMo-L-tryptophan H-TRP(BOC)-OH

  • 5-FLUORO-L-TRYPTOPHAN
  • 5-FLUORO-L-TRYPTOPHAN MONOHYDRATE
  • H-5-FLUORO-TRP-OH H2O
  • L-5-FLUOROTRYPTOPHAN
  • (S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID
  • 5-Fluoro-tryptophan monohydrate
  • H-L-Trp(5-F)-OH*H2O
  • L-5-fluorotryptophan monohydrate
  • (S)-5-Fluoro-α-amino-1H-indole-3-propionic acid
  • (S)-α-Amino-5-fluoro-1H-indole-3-propionic acid
  • (S)-2-AMino-3-(5-fluoro-1H-indol-3-yl)propanoic acid
  • L-Tryptophan, 5-fluoro-
  • (2S)-2-amino-3-(5-fluoro-1H-indol-3-yl)propanoic acid
  • 5-Fluoro-L-tryptophan >=98.0% (HPLC)
  • Tryptophan Impurity 54
  • 5-fluoro-L-tryptophans
  • L-Trp(5-F)-OH
  • 16626-02-1
  • C11H11FN2O2H2O
  • Substrate Analogs
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Type
  • Enzyme Inhibitors
  • Biochemicals and Reagents
  • BioChemical
  • Indoles and derivatives
  • FA - FLEnzyme Inhibitors
  • Substrate AnalogsPeptide Synthesis
  • Alphabetic
  • Enzyme Inhibitors by Type
  • F
  • Tryptophan Derivatives
  • Unnatural Amino Acid Derivatives