2-(HYDROXYMETHYL)BENZO[B]THIOPHENE
- Product Name
- 2-(HYDROXYMETHYL)BENZO[B]THIOPHENE
- CAS No.
- 17890-56-1
- Chemical Name
- 2-(HYDROXYMETHYL)BENZO[B]THIOPHENE
- Synonyms
- BUTTPARK 36\18-21;RARECHEM AL BD 0483;BENZOTHIOPHENE-2-METHANOL;1-Benzothien-2-ylmethanol;1-BENZOTHIOPHEN-2-YLMETHANOL;Benzo[b]thiophene-2-methanol;1-BENZOTHIOPHENE-2-YLMETHANOL;Benzo[b]thiophen-2-ylmethanol;2-(HYDROXYMETHYL)BENZOTHIOPHENE;Benzo[b]thiophene-2-methanol,97%
- CBNumber
- CB1274392
- Molecular Formula
- C9H8OS
- Formula Weight
- 164.22
- MOL File
- 17890-56-1.mol
2-(HYDROXYMETHYL)BENZO[B]THIOPHENE Property
- Melting point:
- 98-101°C
- Boiling point:
- 108-110 °C(Press: 4 Torr)
- Density
- 1.294±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 13.89±0.10(Predicted)
- color
- White to Orange to Green
- CAS DataBase Reference
- 17890-56-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 679542
- Product name
- Benzothiophene-2-methanol
- Purity
- 97%
- Packaging
- 1g
- Price
- $80
- Updated
- 2023/01/07
- Product number
- B4628
- Product name
- Benzo[b]thiophene-2-methanol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $57
- Updated
- 2025/07/31
- Product number
- B4628
- Product name
- Benzo[b]thiophene-2-methanol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $192
- Updated
- 2025/07/31
- Product number
- H999793
- Product name
- 2-(Hydroxymethyl)benzo[b]thiophene
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- H999793
- Product name
- 2-(Hydroxymethyl)benzo[b]thiophene
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
2-(HYDROXYMETHYL)BENZO[B]THIOPHENE Chemical Properties,Usage,Production
Chemical Properties
White to yellow solid
Uses
Benzo[b]thiophene-2-methano is an important intermediates and reagents in organic synthesis.
Synthesis
17890-55-0
17890-56-1
The general procedure for the synthesis of 1-benzothiophene-2-methanol using ethyl benzo[b]thiophene-2-carboxylate as a starting material was as follows: lithium aluminum hydride (712 mg) was suspended in dry tetrahydrofuran (15 mL) and cooled to 0°C in an ice bath. At this temperature, a solution of ethyl benzo[b]thiophene-2-carboxylate (2.06 g, 10 mmol) in tetrahydrofuran (15 mL) was slowly added dropwise. After the dropwise addition was completed, the reaction was kept at 0°C and stirring was continued for 1 hour. Subsequently, the reaction was quenched by careful addition of 1N hydrochloric acid (150 mL) and stirring was continued for 15 minutes. The reaction mixture was extracted with ethyl acetate, the organic layers were combined and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give the white crystalline product 1-benzothiophene-2-methanol (1.51 g, 92% yield). The product was characterized by 1H-NMR (CDCl3, 270 MHz) with chemical shifts of δ= 7.86-7.67 (m, 2H), 7.42-7.20 (m, 3H), 4.91 (s, 2H), 2.02 (bs, 1H).
References
[1] Patent: US2003/109570, 2003, A1
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 3, p. 457 - 465
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 8, p. 2922 - 2926
[4] Organic Letters, 2016, vol. 18, # 8, p. 1828 - 1831
[5] Synlett, 2017, vol. 28, # 1, p. 133 - 137
2-(HYDROXYMETHYL)BENZO[B]THIOPHENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(HYDROXYMETHYL)BENZO[B]THIOPHENE manufacturers
- Product
- 2-(HYDROXYMETHYL)BENZO[B]THIOPHENE 17890-56-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-12-03
- Product
- 2-(HYDROXYMETHYL)BENZO[B]THIOPHENE 17890-56-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 2-(HYDROXYMETHYL)BENZO[B]THIOPHENE 17890-56-1
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-10