3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide
- Product Name
- 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide
- CAS No.
- 1164153-22-3
- Chemical Name
- 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide
- Synonyms
- SR-3576;JNK3 Inhibitor XII;SR-3576 >=98% (HPLC);SR 3576, JNK3 inhibitor;JNK3 Inhibitor XII, SR-3576;JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem;3-[4-(3-m-Tolyl-ureido)-pyrazol-1-yl]-N-(3,4,5-trimethoxy-phenyl)-benzamide;3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide;3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide;Benzamide, 3-[4-[[[(3-methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-
- CBNumber
- CB12750449
- Molecular Formula
- C27H27N5O5
- Formula Weight
- 501.53
- MOL File
- 1164153-22-3.mol
3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Property
- Boiling point:
- 557.7±50.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- pka
- 11.51±0.70(Predicted)
- color
- light brown to brown
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety
- WGK Germany
- 3
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- 420143
- Product name
- JNK3 Inhibitor XII, SR-3576
- Packaging
- 5mg
- Price
- $159
- Updated
- 2024/03/01
- Product number
- 5044
- Product name
- SR3576
- Purity
- ≥97%(HPLC)
- Packaging
- 10
- Price
- $183
- Updated
- 2021/12/16
- Product number
- 5044
- Product name
- SR3576
- Purity
- ≥97%(HPLC)
- Packaging
- 50
- Price
- $753
- Updated
- 2021/12/16
- Product number
- 256745
- Product name
- SR 3576
- Packaging
- 10mg
- Price
- $466
- Updated
- 2021/12/16
- Product number
- S684518
- Product name
- SR3576
- Packaging
- 10mg
- Price
- $195
- Updated
- 2021/12/16
3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Chemical Properties,Usage,Production
Description
SR-3576 (1164153-22-3) is a potent and selective JNK3 inhibitor. IC50?= 7nM and >2800-fold selective over p38.1?Cell permeable.
Uses
SR 3576 is a JNK-3 selective inhibitor.
General Description
A cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC50 = 7 nM), inhibiting JNK1 only at much higher concentrations (IC50 = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 μM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC50 = 1.3 μM).
Biochem/physiol Actions
SR-3576 is a small molecule inhibitor belonging to aminopyrazole class that selectively inhibits JNK3 with >2800 fold selectively over p38.1
storage
Store at -20°C
References
1) Kamenecka?et al. (2009),?Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38; J. Biol. Chem.,?284?12853