LEUKOTRIENE D4

Product Name: LEUKOTRIENE D4
CAS No.: 73836-78-9
Chemical Name: LEUKOTRIENE D4
Synonyms: LTD4;leukotriened;LEUKOTRIENE D4;leukotriened(sub4);LTD4 (Leukotriene D4);Leukotriene D4 (LTD4);Leukotriene D₄;YEESKJGWJFYOOK-IJHYULJSSA-N;(r-(r*,s*-(e,e,z,z)))-inyl);Leukotriene D4 MaxSpecStandard
CBNumber: CB1283439
Molecular Formula: C25H40N2O6S
Formula Weight: 496.66
MOL File: 73836-78-9.mol

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LEUKOTRIENE D4 Property

Boiling point:: 785.8±60.0 °C(Predicted)
Density: 1.162±0.06 g/cm3(Predicted)
Flash point:: 9℃
storage temp.: -70°C
solubility: A solution in ethanol
form: Liquid.
pka: 3.03±0.10(Predicted)
color: Colorless to light yellow

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Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45
RIDADR: UN 1230 3/PG 2
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L5011
Product name: Leukotriene D4
Purity: ~50?μg/mL (in methanol/ammonium acetate buffer, 70:30, pH 5.6), ≥97%
Packaging: 10μg
Price: $326
Updated: 2025/07/31

Sigma-Aldrich

Product number: L5011
Product name: Leukotriene D4
Purity: ~50?μg/mL (in methanol/ammonium acetate buffer, 70:30, pH 5.6), ≥97%
Packaging: 25μg
Price: $647
Updated: 2025/07/31

Sigma-Aldrich

Product number: L5011
Product name: Leukotriene D4
Purity: ~50?μg/mL (in methanol/ammonium acetate buffer, 70:30, pH 5.6), ≥97%
Packaging: 50μg
Price: $977
Updated: 2025/07/31

Sigma-Aldrich

Product number: L5011
Product name: Leukotriene D4
Purity: ~50?μg/mL (in methanol/ammonium acetate buffer, 70:30, pH 5.6), ≥97%
Packaging: 250μg
Price: $2130
Updated: 2022/05/15

Cayman Chemical

Product number: 20310
Product name: Leukotriene D4
Purity: ≥97%
Packaging: 25μg
Price: $144
Updated: 2024/03/01

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LEUKOTRIENE D4 Chemical Properties,Usage,Production

Description

Leukotriene D₄ (LTD₄) is an active metabolite of LTC₄ (Item Nos. 20210 | 10007241) and a constituent of slow-reacting substance of anaphylaxis (SRS-A). It is formed via metabolism of LTC₄ by γ-glutamyl transpeptidase. Like LTC₄, LTD₄ (0.01-0.1 pM) induces contractions in isolated guinea pig parenchymal strips and tracheal spirals. In vivo, LTD₄ increases insufflation pressure, a marker of bronchoconstriction, in anesthetized guinea pigs by 100% when administered at a dose of 89 pmol per animal. It also increases vascular permeability in guinea pig skin when administered intradermally at a dose of 0.1 pmol per animal.

Uses

LTD4 (Leukotriene D4) is a member of the leukotriene family shown to be a potent contractor of smooth muscle.

Definition

ChEBI: A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at position 6 (6R).

Biochem/physiol Actions

Slow reacting substance of anaphylaxis (SRS-A). Potent bronchoconstrictor and mediator of asthmatic and inflammatory processes. Increases cytosolic free Ca2+ in epithelial cells.

in vivo

Leukotriene D4 (1.5, 3, 6, 12, 24 μg/paw; injected intradermally) causes edema and increases capillary permeability in a dose-related manner in mouse^[2].

Animal Model:	21-24 g, Balb/c male mice^[2]
Dosage:	1.5, 3, 6, 12, 24 μg/paw
Administration:	Injected intradermally (10 μL was injected into the left hind paw)
Result:	Caused significant edematous response and dye extravasation at doses of 1.5-6 ~g/paw.

IC 50

Human Endogenous Metabolite

References

[1] L ORNING B S S Hammarstr?m. Leukotriene D: a slow reacting substance from rat basophilic leukemia cells.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1980, 77 4: 2014-2017. DOI: 10.1073/pnas.77.4.2014
[2] S HAMMARSTR?M K B L Orning. Metabolism of leukotrienes.[J]. Molecular and Cellular Biochemistry, 1985, 69 1: 7-16. DOI: 10.1007/bf00225922
[3] PER HEDQVIST. Biological profile of Ieukotrienes C4 and D4[J]. Acta Physiologica, 1980, 110 3: 331-333. DOI: 10.1111/j.1748-1716.1980.tb06676.x
[4] EMILIE CERAUDO. Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling.[J]. The Journal of Biological Chemistry, 2021: 100163. DOI: 10.1074/jbc.ra120.015352
[5] ERICK LU. S-Geranylgeranyl-l-glutathione is a ligand for human B cell-confinement receptor P2RY8[J]. Nature, 2019, 567 7747: 244-248. DOI: 10.1038/s41586-019-1003-z
[6] NATHAN C NI. A selective cysteinyl leukotriene receptor 2 antagonist blocks myocardial ischemia/reperfusion injury and vascular permeability in mice.[J]. Journal of Pharmacology and Experimental Therapeutics, 2011, 339 3: 768-778. DOI: 10.1124/jpet.111.186031
[7] HAI-YAN QI. A cytosolic phospholipase A2-initiated lipid mediator pathway induces autophagy in macrophages.[J]. Journal of immunology, 2011, 187 10: 5286-5292. DOI: 10.4049/jimmunol.1004004
[8] E. ONO. Concentration of 14,15-leukotriene C4 (eoxin C4) in bronchoalveolar lavage fluid[J]. Clinical and Experimental Allergy, 2009, 39 9: 1348-1352. DOI: 10.1111/j.1365-2222.2009.03261.x
[9] PEDRO P MEDINA Montse S C Montse Sanchez Cespedes. Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancer.[J]. Epigenetics, 2008, 3 2: 64-68. DOI: 10.4161/epi.3.2.6153
[10] KARSTEN GRONERT. Selectivity of Recombinant Human Leukotriene D4, Leukotriene B4, and Lipoxin A4 Receptors with Aspirin-Triggered 15-epi-LXA4 and Regulation of Vascular and Inflammatory Responses[J]. American Journal of Pathology, 2001, 158 1: Pages 3-9. DOI: 10.1016/s0002-9440(10)63937-5

LEUKOTRIENE D4 Preparation Products And Raw materials

Raw materials

Preparation Products

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LEUKOTRIENE D4 Suppliers

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73836-78-9, LEUKOTRIENE D4Related Search:

ISOPROPYL N-PROPYL SULFIDE ALLYL ETHYL SULFIDE 2-Pentanethiol ALLYL N-PROPYL SULFIDE 2-Mercapto-3-butanol 1,3,5-UNDECATRIENE 2-[(2-AMINOETHYL)THIO]ETHAN-1-OL CYS-GLY 6-Mercaptohexan-1-ol LEUKOTRIENE B4-3-AMINOPROPYLAMIDE LEUKOTRIENE C4 2-HEPTANETHIOL ETHYL SEC-BUTYL SULFIDE 7-OCTENOIC ACID LEUKOTRIENE D4 Propanamide, 3-mercapto-N-methyl- 2-(butylthio)ethanamine LEUKOTRIENE A3 METHYL ESTER

LEUKOTRIENE D4

(r-(r*,s*-(e,e,z,z)))-inyl)

YEESKJGWJFYOOK-IJHYULJSSA-N

glycine,n-(s-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-l-cyste

leukotriened

leukotriened(sub4)

(5S,6R,7E,9E,11E,14E)-6-[2-amino-2-(carboxymethylcarbamoyl)ethyl]sulfanyl-5-hydroxy-icosa-7,9,11,14-tetraenoic acid

LEUKOTRIENE D4 (ETHANOL SOLUTION)

N-[S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-1-Hydroxy-4-carboxybutyl]-2,4,6,9-pentadecatetraene-1-yl]-L-cysteinyl]glycine

N-[S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-1-Hydroxy-4-carboxybutyl]-2,4,6,9-pentadecatetren-1-yl]-L-cysteinyl]glycine

N-[S-[(1R,2E,4E,6Z,9Z)-1-[(S)-4-Carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetren-1-yl]-L-cysteinyl]glycine

S-[(1R,2E,4E,6Z,9Z)-1-[(S)-4-Carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetren-1-yl]-L-Cys-Gly-OH

LTD4 (Leukotriene D4)

5S-HYDROXY-6R-(S-CYSTEINYLGLYCINYL)-7E,9E,11Z,14Z-EICOSATETRAENOIC ACID

5(S)-HYDROXY-6(R)-S-CYSTEINYLGLYCINYL-7-TRANS-9-TRANS-11-CIS-14-CIS-EICOSATETRAENOIC ACID

LTD4

Glycine, S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-L-cysteinyl-

Leukotriene D4 (LTD4)

Leukotriene D4 MaxSpecStandard

Leukotriene D<sub>4</sub>

Leukotriene D4 (A solution in ethanol)

73836-78-9

BioChemical

Biochemicals and Reagents

Leukotrienes

Lipids

Fatty Acids

Arachidonic Acid Cascade

Fatty Acids

Leukotrienes

LeukotrienesLipids

Lipids in Cell Signaling