2,3-Difluorobenzyl bromide
- Product Name
- 2,3-Difluorobenzyl bromide
- CAS No.
- 113211-94-2
- Chemical Name
- 2,3-Difluorobenzyl bromide
- Synonyms
- CAS:113211-94-2;TIMTEC-BB SBB006681;2,3-DIFLUOROBENZYL BROMIDE;2,3-Difluorophenyl bromide;α-bromo-2,3-difluorotoluene;à-bromo-2,3-difluorotoluene;2,3-Difluorobenzylbromide98%;2,3-DifluorobenzylBromide>2,3-Difluorobenzyl bromide 98%;ALPHA-BROMO-2,3-DIFLUOROTOLUENE
- CBNumber
- CB1285064
- Molecular Formula
- C7H5BrF2
- Formula Weight
- 207.02
- MOL File
- 113211-94-2.mol
2,3-Difluorobenzyl bromide Property
- Boiling point:
- 190.5±25.0 °C(Predicted)
- Density
- 1.628 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.528(lit.)
- Flash point:
- 194 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- clear liquid
- color
- Colorless to Light yellow
- Specific Gravity
- 1.628
- Sensitive
- Lachrymatory
- BRN
- 7089244
- CAS DataBase Reference
- 113211-94-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,3-Difluorobenzyl bromide(113211-94-2)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34-36/37/38
- Safety Statements
- 26-36/37/39-45-25-36/37
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- F
- 10-19-21
- Hazard Note
- Corrosive/Lachrymatory
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29049090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 265314
- Product name
- 2,3-Difluorobenzyl bromide
- Purity
- 98%
- Packaging
- 5g
- Price
- $43.75
- Updated
- 2025/07/31
- Product number
- D4320
- Product name
- 2,3-Difluorobenzyl Bromide
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $26
- Updated
- 2025/07/31
- Product number
- D4320
- Product name
- 2,3-Difluorobenzyl Bromide
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $103
- Updated
- 2025/07/31
- Product number
- D450868
- Product name
- 2,3-Difluorobenzyl bromide
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- D450868
- Product name
- 2,3-Difluorobenzyl bromide
- Packaging
- 10g
- Price
- $95
- Updated
- 2021/12/16
2,3-Difluorobenzyl bromide Chemical Properties,Usage,Production
Chemical Properties
clear colorless to light yellow liquid
Uses
2,3-Difluorobenzyl bromide was used in the synthesis of chemokine antagonists.
Synthesis
75853-18-8
113211-94-2
Step 2 (MW-S2): phosphorus tribromide (6.7 mL, 69.44 mmol) was added dropwise to a solution of diethyl ether (250 mL) of 2,3-difluorobenzyl alcohol (20 g, 138.88 mmol) at -10 °C. The reaction mixture was stirred at -10 °C for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate solution. The organic layer was separated and the aqueous layer was extracted with diethyl ether (2 x 100 mL). The combined organic layers were washed sequentially with water (100 mL), brine (100 mL), dried with anhydrous sodium sulfate, filtered and concentrated in vacuum to give 20 g of 2,3-difluorobenzyl bromide (MW-52) as a light brown liquid, which can be used in the next reaction without further purification.
References
[1] Journal of Medicinal Chemistry, 1988, vol. 31, # 5, p. 1005 - 1009
[2] Patent: WO2014/140279, 2014, A1. Location in patent: Page/Page column 88; 170
2,3-Difluorobenzyl bromide Preparation Products And Raw materials
Raw materials
Preparation Products
2,3-Difluorobenzyl bromide Suppliers
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View Lastest Price from 2,3-Difluorobenzyl bromide manufacturers
- Product
- 2,3-Difluorobenzyl bromide 113211-94-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-11-07
- Product
- 2,3-Difluorobenzyl bromide 113211-94-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-09
- Product
- 2,3-Difluorobenzyl bromide 113211-94-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-18