Nicorandil
- Product Name
- Nicorandil
- CAS No.
- 65141-46-0
- Chemical Name
- Nicorandil
- Synonyms
- 2-[(Pyridin-3-ylcarbonyl)amino]ethyl nitrate, N-[2-(Nitroxy)ethyl]pyridine-3-carboxamide;SG-75;Dancor;IKOREL;Zynicor;SIGMART;ADANCOR;Nicodil;Nicordil;PERISALOL
- CBNumber
- CB1291140
- Molecular Formula
- C8H9N3O4
- Formula Weight
- 211.17
- MOL File
- 65141-46-0.mol
Nicorandil Property
- Melting point:
- 92°C
- Boiling point:
- 350.85°C (rough estimate)
- Density
- 1.4271 (rough estimate)
- refractive index
- 1.7400 (estimate)
- RTECS
- US4667600
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- form
- powder
- pka
- 12.70±0.46(Predicted)
- color
- white to off-white
- Merck
- 14,6521
- InChI
- InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)
- InChIKey
- LBHIOVVIQHSOQN-UHFFFAOYSA-N
- SMILES
- C1=NC=CC=C1C(NCCO[N+]([O-])=O)=O
- CAS DataBase Reference
- 65141-46-0
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H242Heating may cause a fire
H302Harmful if swallowed
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P235Keep cool.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P370+P378In case of fire: Use … for extinction.
P410Protect from sunlight.
N-Bromosuccinimide Price
- Product number
- N3539
- Product name
- Nicorandil
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $83.98
- Updated
- 2025/07/31
- Product number
- Y0001761
- Product name
- Nicorandil
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 5 mg
- Price
- $153
- Updated
- 2025/07/31
- Product number
- N3539
- Product name
- Nicorandil
- Purity
- ≥98% (HPLC)
- Packaging
- 250mg
- Price
- $357
- Updated
- 2025/07/31
- Product number
- N0837
- Product name
- Nicorandil
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 100mg
- Price
- $60
- Updated
- 2025/07/31
- Product number
- N0837
- Product name
- Nicorandil
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $112
- Updated
- 2025/07/31
Nicorandil Chemical Properties,Usage,Production
Chemical Properties
Nicorandil is N-(2-hydroxyethyl)-nicotinamide nitrate (ester). It is a white crystalline powder or white needles with a faint, characteristic odour. It is freely soluble in methanol, ethanol, acetone or glacial acetic acid, slightly soluble in chloroform or water, almost insoluble in ether or benzene. Melting point 88.5-93.5 ℃. Acute toxicity LD50 rat (mg/kg): 1200-1300 orally, 800-1000 intravenously.
Originator
Chugai (Japan)
Uses
Nicorandil is a vasodilator used for the prophylaxis and treatment of angina. This medication widens blood vessels thus increasing the blood and oxygen flow to the heart. It is not currently available in the US.
Nicorandil is a nitric oxide donor and ATP-sensitive potassium channel opener. A study showed that Nicorandil is able to protect against stress-induced cell death in dystrophin-deficient cardiomyocytes and also preserve cardiac function in the mdx mouse heart subjected to ischemia and reperfusion injury.
Definition
ChEBI: Nicorandil is a pyrimidinecarboxamide that is nicotinamide in which one of the hydrogens attached to the carboxamide nitrogen is replaced by a 2-(nitrooxy)ethyl group. It has both nitrate-like and ATP-sensitive potassium channel activator properties, and is used for the prevention and treatment of angina pectoris. It has a role as a vasodilator agent and a potassium channel opener. It is a pyridinecarboxamide and a nitrate ester. It derives from a nicotinamide.
Preparation
Nicorandil is obtained by treating nicotinic acid chloride hydrochloride with nitro-oxy-ethyl-amine nitrate in an organic solvent.
Nicorandil was synthesized from 2-aminoethanol by a four step process. In order to protect the amino group during nitration, 2-aminoethanol was first treated with phthalic anhydride. The amide formed was then nitrated using a nitrating mixture and was subsequently deprotected by reacting with hydrazine hydrate. The 2- nitroxyethylamine obtained was condensed with nicotinoyl chloride in pyridine. Treatment with aqueous sodium bicarbonate solution gave nicorandil as free base.
synthesis of Nicorandil
brand name
SIGMART; PERISALOL
Biochem/physiol Actions
Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction.
Clinical Use
Nicorandil is used for the prevention and treatment of chronic stable angina. It is usually used when angina becomes difficult to control by other drugs and is given as an additional treatment.
Synthesis
6265-73-2
65141-46-0
General procedure for the synthesis of ethyl 2-(pyridine-3-carbonylamino)nitrate from N-(2-hydroxyethyl)-3-pyridinecarboxamide: Fuming nitric acid (10 mmol) was mixed with N-(2-hydroxyethyl)-3-pyridinecarboxamide (1 mmol) and the reaction was carried out with continuous stirring for 2 h at -5.0 °C to obtain the nitration product. After completion of the reaction, the reaction mixture was slowly poured into a pre-prepared ice-water mixture. Subsequently, the pH of the mixture was adjusted to 6.0 with calcium carbonate (CaCO3).The resulting solid product was collected by vacuum filtration and purified by recrystallization in ethanol to finally obtain ethyl 2-(pyridine-3-carbonylamino)nitrate in white crystalline form.
Drug interactions
Potentially hazardous interactions with other drugs
Avanafil, sildenafil, tadalafil and vardenafil: enhanced
hypotensive effect - avoid.
Riociguat: possible enhanced hypotensive effect -
avoid.
Metabolism
Metabolism of nicorandil is mainly by denitration of the molecule into the nicotinamide pathway. About 20% of a dose is excreted in the urine mainly as metabolites
Mode of action
The coronary vasodilating activity of nicorandil is considered to be the consequence of the increasing cyclic GMP production by stimulating guanylyl cyclase in the coronary vascular smooth muscle, similar to other nitrates/nitrites (in vitro). In addition, other mechanisms such as hyperpolarization of the cell membrane were investigated concerning its coronary blood flowincreasing and coronary vasospasmolytic effects.
The vasorelaxant effect of nicorandil in isolated blood vessels is suppressed by an ATP-sensitive K channel blocker or a guanylate cyclase inhibitor. Moreover, in a canine model of acute heart failure, the cardiac haemodynamics-improving effect of the drug (e.g. effect of increasing the aortic blood flow) was suppressed by an ATP-sensitive K channel blocker. Furthermore, the drug caused an increase in the cGMP content in isolated blood vessels. These facts suggest that the vasodilating effect of the drug is related to the effect of opening the ATP-sensitive K channel, as well as to the effect of increasing production of cGMP.
References
[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 9, p. 2783 - 2790
[2] Patent: WO2012/89769, 2012, A1. Location in patent: Page/Page column 9-10
Nicorandil Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Nicorandil manufacturers
- Product
- Nicorandil 65141-46-0
- Price
- US $5.00-0.50/KG
- Min. Order
- 0.10000000149011612KG
- Purity
- 99% hplc
- Supply Ability
- 5000kg
- Release date
- 2025-06-11
- Product
- Nicorandil 65141-46-0
- Price
- US $0.00/G
- Min. Order
- 100G
- Purity
- 98%min
- Supply Ability
- 30KG/month
- Release date
- 2023-01-31
- Product
- Nicorandil 65141-46-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-10-24