Nicorandil

ChemicalBook > CAS DataBase List > Nicorandil

Product Name: Nicorandil
CAS No.: 65141-46-0
Chemical Name: Nicorandil
Synonyms: 2-[(Pyridin-3-ylcarbonyl)amino]ethyl nitrate, N-[2-(Nitroxy)ethyl]pyridine-3-carboxamide;SG-75;Dancor;IKOREL;Zynicor;SIGMART;ADANCOR;Nicodil;Nicordil;PERISALOL
CBNumber: CB1291140
Molecular Formula: C8H9N3O4
Formula Weight: 211.17
MOL File: 65141-46-0.mol

Less

Nicorandil Property

Melting point:: 92°C
Boiling point:: 350.85°C (rough estimate)
Density: 1.4271 (rough estimate)
refractive index: 1.7400 (estimate)
RTECS: US4667600
storage temp.: 2-8°C
solubility: DMSO: >10mg/mL
form: powder
pka: 12.70±0.46(Predicted)
color: white to off-white
Merck: 14,6521
CAS DataBase Reference: 65141-46-0

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 3
HS Code: 29333990
Toxicity: LD50 in rats (mg/kg): 1200-1300 orally; 800-1000 i.v. (Nagano)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H242Heating may cause a fire

H302Harmful if swallowed

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P235Keep cool.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P370+P378In case of fire: Use … for extinction.

P410Protect from sunlight.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N3539
Product name: Nicorandil
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $86
Updated: 2024/03/01

Sigma-Aldrich

Product number: N3539
Product name: Nicorandil
Purity: ≥98% (HPLC)
Packaging: 250mg
Price: $347
Updated: 2024/03/01

TCI Chemical

Product number: N0837
Product name: Nicorandil
Purity: >98.0%(HPLC)(T)
Packaging: 100mg
Price: $66
Updated: 2024/03/01

TCI Chemical

Product number: N0837
Product name: Nicorandil
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $124
Updated: 2024/03/01

Alfa Aesar

Product number: J60879
Product name: Nicorandil, 98+%
Packaging: 250mg
Price: $81.65
Updated: 2024/03/01

Less

Nicorandil Chemical Properties,Usage,Production

Chemical Properties

Nicorandil is N-(2-hydroxyethyl)-nicotinamide nitrate (ester). It is a white crystalline powder or white needles with a faint, characteristic odour. It is freely soluble in methanol, ethanol, acetone or glacial acetic acid, slightly soluble in chloroform or water, almost insoluble in ether or benzene. Melting point 88.5-93.5 ℃. Acute toxicity LD50 rat (mg/kg): 1200-1300 orally, 800-1000 intravenously.

Originator

Chugai (Japan)

Uses

Nicorandil is a vasodilator used for the prophylaxis and treatment of angina. This medication widens blood vessels thus increasing the blood and oxygen flow to the heart. It is not currently available in the US.
Nicorandil is a nitric oxide donor and ATP-sensitive potassium channel opener. A study showed that Nicorandil is able to protect against stress-induced cell death in dystrophin-deficient cardiomyocytes and also preserve cardiac function in the mdx mouse heart subjected to ischemia and reperfusion injury.

Definition

ChEBI: Nicorandil is a pyrimidinecarboxamide that is nicotinamide in which one of the hydrogens attached to the carboxamide nitrogen is replaced by a 2-(nitrooxy)ethyl group. It has both nitrate-like and ATP-sensitive potassium channel activator properties, and is used for the prevention and treatment of angina pectoris. It has a role as a vasodilator agent and a potassium channel opener. It is a pyridinecarboxamide and a nitrate ester. It derives from a nicotinamide.

Preparation

Nicorandil is obtained by treating nicotinic acid chloride hydrochloride with nitro-oxy-ethyl-amine nitrate in an organic solvent.

Nicorandil was synthesized from 2-aminoethanol by a four step process. In order to protect the amino group during nitration, 2-aminoethanol was first treated with phthalic anhydride. The amide formed was then nitrated using a nitrating mixture and was subsequently deprotected by reacting with hydrazine hydrate. The 2- nitroxyethylamine obtained was condensed with nicotinoyl chloride in pyridine. Treatment with aqueous sodium bicarbonate solution gave nicorandil as free base.
synthesis of Nicorandil

brand name

SIGMART; PERISALOL

Biochem/physiol Actions

Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction.

Clinical Use

Nicorandil is used for the prevention and treatment of chronic stable angina. It is usually used when angina becomes difficult to control by other drugs and is given as an additional treatment.

Drug interactions

Potentially hazardous interactions with other drugs
Avanafil, sildenafil, tadalafil and vardenafil: enhanced hypotensive effect - avoid.
Riociguat: possible enhanced hypotensive effect - avoid.

Metabolism

Metabolism of nicorandil is mainly by denitration of the molecule into the nicotinamide pathway. About 20% of a dose is excreted in the urine mainly as metabolites

Mode of action

The coronary vasodilating activity of nicorandil is considered to be the consequence of the increasing cyclic GMP production by stimulating guanylyl cyclase in the coronary vascular smooth muscle, similar to other nitrates/nitrites (in vitro). In addition, other mechanisms such as hyperpolarization of the cell membrane were investigated concerning its coronary blood flowincreasing and coronary vasospasmolytic effects.
The vasorelaxant effect of nicorandil in isolated blood vessels is suppressed by an ATP-sensitive K channel blocker or a guanylate cyclase inhibitor. Moreover, in a canine model of acute heart failure, the cardiac haemodynamics-improving effect of the drug (e.g. effect of increasing the aortic blood flow) was suppressed by an ATP-sensitive K channel blocker. Furthermore, the drug caused an increase in the cGMP content in isolated blood vessels. These facts suggest that the vasodilating effect of the drug is related to the effect of opening the ATP-sensitive K channel, as well as to the effect of increasing production of cGMP.

Nicorandil Preparation Products And Raw materials

Raw materials

2-N-BUTOXYETHYL METHACRYLATE Methyl nicotinate Monoethanolamine Nicotinoyl chloride hydrochloride Nitric acid

Preparation Products

Less

Nicorandil Suppliers

Americas 1 Belgium 2 Brazil 1 Canada 6 China 278 Czech Republic 1 Europe 3 France 1 Germany 5 India 76 Italy 1 Japan 5 Russia 1 Sweden 1 Switzerland 1 United Arab Emirates 1 United Kingdom 16 United States 49 Global 449

Guangzhou Dreampharm Biotechnology Co., Ltd.

Tel: 020-36607679 17825480238
Fax: QQ 3008233717
Email: 3008233746@qq.com
Country: China
ProdList: 9919
Advantage: 12

Jinan Wald Chemical Co., Ltd.

Tel: 0531-88773586 13210588999
Fax: 053188773586
Email: 304264064@qq.com
Country: China
ProdList: 193
Advantage: 58

Xi'an Kaimeike New Material Co., Ltd.

Tel: 13720451009
Email: 13720451009@163.com
Country: China
ProdList: 164
Advantage: 58

Shandong Shengzhiyuan Biotechnology Co., LTD

Tel: 13589515191
Email: 513449328@qq.com
Country: China
ProdList: 120
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 8418
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Wuhan Wei Shunda Technology Development Co., Ltd.

Tel: 86-027-88774375
Fax: 86-027-88416321
Email: mwmwhot@163.com
Country: China
ProdList: 233
Advantage: 65

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9810
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7195
Advantage: 65

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

Wuhan Haizheng Industry & Trade Development Co. Ltd

Tel: 027-8866 0053/88660577/88660578
Fax: 027-8899 1911
Country: China
ProdList: 1073
Advantage: 55

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5047
Advantage: 50

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4566
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4674
Advantage: 55

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

Frandcom Industrial Limited

Tel: 86-533-2151679
Fax: 86-533-2151675
Email: info@frandcom.com
Country: China
ProdList: 58
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Eastbang Pharmaceuticals Technology Co., Ltd.

Tel: +86 (20) 28996708,29078958,28139708,29076128,28133708,28139728,28139738,28133718,021-31663278,021-31663578,021-60538387
Fax: +86 (20) 39218032
Country: China
ProdList: 454
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18070
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4943
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10274
Advantage: 55

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.

Tel: 027-59420981,18702770802
Fax: 027-83322098
Country: China
ProdList: 1975
Advantage: 50

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9958
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Guangzhou Ciming Biological Technology Co., Ltd.

Tel: 020-38082199,29065168,38082986,29878298,29866629,4000192398
Fax: +86 (20)38082986
Country: China
ProdList: 830
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 17687
Advantage: 55

Nanjing Vital Chemical Co., Ltd.

Tel: 025-87193546 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 9021
Advantage: 60

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10453
Advantage: 58

Nanjing XiLang Chemical Products Co., Ltd.

Tel: 18936048580
Email: chemxilang@163.com
Country: China
ProdList: 4007
Advantage: 58

Zhengzhou Alfachem Co.,Ltd.

Tel: 0371-53778726 18003825608
Fax: QQ：2885354392
Email: liuxiaoyan@alfachem.cn
Country: China
ProdList: 1992
Advantage: 58

Less

View Lastest Price from Nicorandil manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Nicorandil 65141-46-0
Price: US $0.00/G
Min. Order: 100G
Purity: 98%min
Supply Ability: 30KG/month
Release date: 2023-01-31

Hebei Yanxi Chemical Co., Ltd.

Product: nicorandil 65141-46-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-10

Hebei Weibang Biotechnology Co., Ltd

Product: Nicorandil 65141-46-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-24

65141-46-0, NicorandilRelated Search:

Nicotinamide Ethanol Ethylparaben Ethyl acrylate Ethyl vanillin Ethyl 4-hydroxy-3-methoxycinnamate Ethyl acetate Ethyl nitrate 1-(2,6-Dimethylphenoxy)-2-propanamine Ethyl nitrite Aminoethyl nitrate N-(2-HYDROXYETHYL)NITOTINAMIDE 2-HYDROXYETHYL N-PENTYL SULPHIDE, 95 NICORANDIL-D4,NICORANDIL-D4 (PYRIDYL-D4) 3-Pyridinecarboxaldehyde-D4 NICOTINAMIDE-2,4,5,6-D4 Nicorandil Nicorandil fumaric acid salt

n-[2-(nitroxy)ethyl]-3-pyridinecarboxamide

N-[2-(NITROOXY)ETHYL]-3-PYRIDINECARBOXAMIDE

2-[(Pyridin-3-ylcarbonyl)amino]ethyl nitrate, N-[2-(Nitroxy)ethyl]pyridine-3-carboxamide

3-Pyridinecarboxamide, N-[2-(nitrooxy)ethyl]-

SG-75

Dancor

Nitric acid 2-nicotinoylaminoethyl ester

2-(pyridin-3-ylcarbonylamino)ethyl nitrate

2-(pyridine-3-carbonylamino)ethyl nitrate

nitric acid 2-(pyridine-3-carbonylamino)ethyl ester

N-(2-Hydroxyethyl)nieotimmide nitrate(ester)

2-(pyridin-3-ylforMaMido)ethyl nitrate

Nicorandil(Ikorel)

Nicorandil, 98%, a potassium channel activator

N-(2-Nitrooxyethyl)nicotinaMide

2-(Pyridine-3-carboxamido)ethyl Nitrate N-[2-(Nitrooxy)ethyl]pyridine-3-carboxamide

Zynicor

NICORANDIL

PERISALOL

SIGMART

N-[2-Hydroxyethyl] nicotinamide nitrate

Adancor, Ikorel, Perisalol, Sigmart

IKOREL

ADANCOR

2-nicotinamidoethylnitrate

n-(2-(nitrooxy)ethyl)-3-pyridinecarboxamid

n-(2-hydroxyethyl)nicotinamidenitrate(ester)

2-[(3-pyridinylcarbonyl)amino]ethyl nitrate

Nicorandil&gt

Nicorandil CRS

2-(Pyridine-3-carboxamido)ethyl Nitrate

N-[2-(Nitrooxy)ethyl]pyridine-3-carboxamide

Nicorandil USP/EP/BP

Nicorandil (SG-75)

Nicorandil, ≥98% (HPLC)

NicorandilQ: What is Nicorandil Q: What is the CAS Number of Nicorandil Q: What is the storage condition of Nicorandil Q: What are the applications of Nicorandil

Nicorandil Impurity 45

Nicordil

Nicorandil IP/BP

Nicorandi

Nicorandil, ≥ 98.0%

Nicorandil CAS

Nicodil

65141-46-0

Pharmaceutical

Ikorel

reagent

Cardiovascular APIs

Potassium channel

Intermediates & Fine Chemicals

Pharmaceuticals

Aromatics

Heterocycles

65141-46-0