ChemicalBook > CAS DataBase List > 2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE

2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE

Product Name: 2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE
CAS No.: 14080-51-4
Chemical Name: 2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE
Synonyms: AKOS 93830;AKOS B014696;CHEMBRDG-BB 3014696;ART-CHEM-BB B014696;TIMTEC-BB SBB007065;2-AMino-3-carbaMoylthiophene;2-AMINOTHIOPHENE-3-CARBOXAMIDE;2-AMINO-3-THIOPHENECARBOXAMIDE;3-Thiophenecarboxamide, 2-amino-;2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE
CBNumber: CB1293472
Molecular Formula: C5H6N2OS
Formula Weight: 142.18
MOL File: 14080-51-4.mol

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2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE Property

Melting point:: 153-155°C
Boiling point:: 321.8±22.0 °C(Predicted)
Density: 1.423±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: powder to crystal
pka: 15.58±0.50(Predicted)
color: White to Orange to Green
InChI: InChI=1S/C5H6N2OS/c6-4(8)3-1-2-9-5(3)7/h1-2H,7H2,(H2,6,8)
InChIKey: WHZIZZOTISTHCT-UHFFFAOYSA-N
SMILES: C1(N)SC=CC=1C(N)=O
CAS DataBase Reference: 14080-51-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36-43
Safety Statements: 26-36/37
HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS007582
Product name: 2-amino-thiophene-3-carboxylic acid amide
Purity: AldrichCPR
Packaging: 500MG
Price: $107
Updated: 2025/07/31

TCI Chemical

Product number: A3165
Product name: 2-Aminothiophene-3-carboxamide
Purity: >98.0%(GC)
Packaging: 1g
Price: $29
Updated: 2025/07/31

TCI Chemical

Product number: A3165
Product name: 2-Aminothiophene-3-carboxamide
Purity: >98.0%(GC)
Packaging: 5g
Price: $138
Updated: 2025/07/31

TRC

Product number: A615605
Product name: 2-Aminothiophene-3-carboxamide
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: A615605
Product name: 2-Aminothiophene-3-carboxamide
Packaging: 50mg
Price: $60
Updated: 2021/12/16

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2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE Chemical Properties,Usage,Production

Synthesis

40018-26-6

107-91-5

14080-51-4

General procedure for the synthesis of 2-aminothiophene-3-amides from 1,4-dithio-2,5-diol and cyanoacetamide: Triethylamine (36 mL, 256 mmol) was added to a solution of ethanol (400 mL) containing 2-cyanoacetamide (10.8 g, 128 mmol) and 1,4-dithiazan-2,5-diol (19.5 g, 128 mmol). The reaction mixture was stirred at room temperature for 5 minutes and then heated to reflux for 2 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered and concentrated in vacuum. The residue was dissolved in ethyl acetate (400 mL) and washed sequentially with 1 M aqueous sodium hydroxide (200 mL), water (2 x 200 mL) and brine (200 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo to give 2-aminothiophene-3-amide (16 g, 113 mmol, 88% yield) as a light yellow solid.LC-MS [M+H]+ m/z 143.

References

[1] Patent: WO2003/104218, 2003, A1. Location in patent: Page 13
[2] Synthesis (Germany), 2013, vol. 45, # 1, p. 45 - 52
[3] Patent: WO2012/30894, 2012, A1. Location in patent: Page/Page column 87
[4] Tetrahedron Letters, 2007, vol. 48, # 30, p. 5261 - 5264
[5] Journal of Medicinal Chemistry, 2011, vol. 54, # 19, p. 6734 - 6750

2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-Amino-3-thiophenecarboxamide 14080-51-4
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE 14080-51-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE 14080-51-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-14

14080-51-4, 2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDERelated Search:

2-AMINO-4-METHYLTHIOPHENE-3-CARBOXAMIDE 2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXAMIDE ETHYL 5-METHYL-4-OXO-3,4-DIHYDROTHIENO[2,3-D]-PYRIMIDINE-6-CARBOXYLATE 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE 5-PHENYL-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE (1)benzothieno(2,3-d)pyrimidin-4(1h)-one,2,3,5,6,7,8-hexahydro-3-methyl-2-thio AKOS 94123 2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE 5-thien-2-ylthieno[2,3-d]pyrimidin-4(3H)-one 2-[(CHLOROACETYL)AMINO]THIOPHENE-3-CARBOXAMIDE 3-ETHYL-2-MERCAPTO-5,6,7,8-TETRAHYDRO-3H-BENZO[4,5]THIENO[2,3-D]PYRIMIDIN-4-ONE AKOS BBS-00007188 3-CYCLOHEXYL-2-MERCAPTO-5,6,7,8-TETRAHYDRO-3H-BENZO[4,5]THIENO[2,3-D]PYRIMIDIN-4-ONE 7-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-2-[(2,4-DICHLOROBENZYL)SULFANYL]-3-METHYL-5,6,7,8-TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE AKOS 90535 7-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-3-METHYL-2-SULFANYL-5,6,7,8-TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE AKOS BBS-00007201 AKOS BBS-00007193

TIMTEC-BB SBB007065

2-AMINOTHIOPHENE-3-CARBOXAMIDE

2-AMINO-THIOPHENE-3-CARBOXYLIC ACID AMIDE

2-AMINO-3-THIOPHENECARBOXAMIDE

AKOS B014696

AKOS 93830

ART-CHEM-BB B014696

CHEMBRDG-BB 3014696

2-amino-thiophene-3-3carboxyltc acid amide

2-aminothiophene-3-carboxamide(SALTDATA: FREE)

2-AMino-3-carbaMoylthiophene

3-Thiophenecarboxamide, 2-amino-

14080-51-4

C5H6SON2